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Sugi Predict / Targets / PLA2G5

PLA2G5

Phospholipase A2 group V · P39877 · PLA2G5 on Sugi Atlas →

11,155 patent compounds predicted against PLA2G5, 5,587 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL818585 SCHEMBL818585 0.85 6/20
SCHEMBL3200896 SCHEMBL3200896 0.58 6/20
SCHEMBL818840 SCHEMBL818840 0.53 6/20
Varespladib Varespladib (SCHEMBL26726) 1.00 5/20
Varespladib Methyl Varespladib Methyl (SCHEMBL25678) 0.83 5/20
Varespladib Varespladib (SCHEMBL1232548) 0.83 5/20
SCHEMBL818498 SCHEMBL818498 0.79 5/20
SCHEMBL2157246 SCHEMBL2157246 0.76 5/20
SCHEMBL2157506 SCHEMBL2157506 0.75 5/20
SCHEMBL818717 SCHEMBL818717 0.70 5/20
SCHEMBL3197239 SCHEMBL3197239 0.66 5/20
SCHEMBL3198216 SCHEMBL3198216 0.59 5/20
SCHEMBL2590552 SCHEMBL2590552 0.52 5/20
SCHEMBL818386 SCHEMBL818386 0.51 5/20
SCHEMBL818733 SCHEMBL818733 0.50 5/20
SCHEMBL817908 SCHEMBL817908 1.00 4/20
SCHEMBL819141 SCHEMBL819141 1.00 4/20
SCHEMBL818631 SCHEMBL818631 0.90 4/20
SCHEMBL819886 SCHEMBL819886 0.86 4/20
SCHEMBL2156611 SCHEMBL2156611 0.86 4/20

Clinical trials — most relevant to PLA2G5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial PHASE4NOT_YET_RECRUITING
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis PHASE3COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
Montelukast in Parkinson Disease PHASE2/PHASE3RECRUITING
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM PHASE3COMPLETED
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide PHASE1COMPLETED
Assessment of Coronary Plaque Composition PHASE1COMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes nanCOMPLETED
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
PET Imaging of DHA Metabolism nanCOMPLETED
Role of PLA2G1B During HIV Infection nanUNKNOWN
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms nanCOMPLETED
LDL-Apheresis for FSGS CardioRenal Outcomes nanCOMPLETED
Heart & Health Study nanCOMPLETED
Validation of an Assay to Measure Cyclooxygenase-1 Activity nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
NETs: Protection or Harm in Neonatal Inflammation or Infection nanRECRUITING
Molecular Markers of Human Sperm Function nanWITHDRAWN
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates nanRECRUITING
Fish Oil-derived N-3 Polyunsaturated Fatty Acids and Extracellular Vesicles nanCOMPLETED
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer nanCOMPLETED
Lp-PLA2 and Coronary Atherosclerosis in Humans nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PLA2G5 binder may also engage these)

ProteinNameSimilarity
P97391 — 1.000 P97391 →
P51433 — 0.995 P51433 →
P24027 — 0.995 P24027 →
PLA2G2D Group IID secretory phospholipase A2 0.994 landscape →
P47711 — 0.994 P47711 →
P20474 — 0.993 P20474 →
Q6H3C7 — 0.993 Q6H3C7 →
Q910A0 — 0.993 Q910A0 →
A8CG90 — 0.993 A8CG90 →
Q9PUH2 — 0.992 Q9PUH2 →
P49121 — 0.992 P49121 →
P00611 — 0.992 P00611 →
Q56JZ2 — 0.992 Q56JZ2 →
Q2YHJ7 — 0.992 Q2YHJ7 →
A8E2V8 — 0.992 A8E2V8 →
P00615 — 0.992 P00615 →
Q90W39 — 0.992 Q90W39 →
Q6H3C9 — 0.991 Q6H3C9 →
Q6EER4 — 0.991 Q6EER4 →
Q2PG83 — 0.991 Q2PG83 →
Q90249 — 0.991 Q90249 →
F5CPF1 — 0.991 F5CPF1 →
Q7ZTA8 — 0.991 Q7ZTA8 →
Q45Z27 — 0.991 Q45Z27 →
Q9WVF6 — 0.991 Q9WVF6 →
P20146 — 0.991 P20146 →
Q7ZTA7 — 0.991 Q7ZTA7 →
Q9PVE9 — 0.990 Q9PVE9 →
Q45Z42 — 0.990 Q45Z42 →
P62023 — 0.990 P62023 →