PPP2R5A

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform · Q15172 · PPP2R5A on Sugi Atlas →

109 patent compounds predicted against PPP2R5A, 105 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Calyculin A Calyculin A (SCHEMBL82924) 1.00 1/20
Calyculin A Calyculin A (SCHEMBL82925) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL131485) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL2386832) 1.00 1/20
Calyculin A Calyculin A (SCHEMBL4295478) 1.00 1/20
Calyculin A Calyculin A (SCHEMBL4299349) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL17899362) 1.00 1/20
Microcystin-Lr Microcystin-Lr (SCHEMBL21245230) 1.00 1/20
Microcystin-Lr Microcystin-Lr (SCHEMBL21245231) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL21408784) 1.00 1/20
Calyculin A Calyculin A (SCHEMBL21408822) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL22024950) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL23350437) 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL24418495) 1.00 1/20
Microcystin-Lr Microcystin-Lr (SCHEMBL29349513) 1.00 1/20
Calyculin A Calyculin A (SCHEMBL29406338) 1.00 1/20
Calyculin B Calyculin B (SCHEMBL29809573) 1.00 1/20
SCHEMBL29897131 SCHEMBL29897131 1.00 1/20
Okadaic Acid Okadaic Acid (SCHEMBL544727) 0.99 1/20
Okadaic Acid Okadaic Acid (SCHEMBL545387) 0.99 1/20

Clinical trials — most relevant to PPP2R5A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis PHASE4COMPLETED
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds PHASE2/PHASE3COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Everolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma PHASE2COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer PHASE1/PHASE2COMPLETED
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma PHASE2COMPLETED
Open-label Study on Treatment of Primary Aldosteronism With Everolimus PHASE2COMPLETED
A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis PHASE1/PHASE2COMPLETED
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL PHASE1/PHASE2RECRUITING
Everolimus for Children With Recurrent or Progressive Ependymoma PHASE2COMPLETED
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer PHASE2COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Bioequivalence Study of Tacrolimus in Healthy Volunteers PHASE1COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery PHASE1COMPLETED
Quantification of GADD34 Expression in RA nanCOMPLETED
Immune Signature of Palmoplantar Pustulosis nanCOMPLETED
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease nanUNKNOWN
NGS in Gallbladder Cancer and Response to Treatment nanRECRUITING
Study of Metabolic Modifications in Children With Noonan Syndrome nanCOMPLETED
Studies of the Tumour Suppressor Gene PTEN - Endometrial Cancer nanCOMPLETED
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure nanRECRUITING
Studying Phosphorus Metabolism nanCOMPLETED
Phosphoproteomic Profile of Children With Down Syndrome nanCOMPLETED
Studying Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia Previously Enrolled on Clinical Trial POG-9421 nanCOMPLETED
Molecular Analysis in Tissue Samples From Patients With Advanced or Metastatic Neuroendocrine Tumors nanUNKNOWN
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Severe Insulin Resistance in Patients With Type 2 Diabetes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PPP2R5A binder may also engage these)

ProteinNameSimilarity
Q6PD03 1.000 Q6PD03 →
Q16537 1.000 Q16537 →
Q61151 1.000 Q61151 →
Q28653 1.000 Q28653 →
PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 1.000 landscape →
Q9SV41 1.000 Q9SV41 →
Q9ZQY6 1.000 Q9ZQY6 →
Q8LF36 1.000 Q8LF36 →
A4FV68 1.000 A4FV68 →
O18178 1.000 O18178 →
Q93YV6 1.000 Q93YV6 →
Q9LVE2 1.000 Q9LVE2 →
Q60996 1.000 Q60996 →
Q13362 0.999 Q13362 →
Q9LU89 0.999 Q9LU89 →
O04376 0.999 O04376 →
Q8RW96 0.998 Q8RW96 →
Q6PD28 0.998 Q6PD28 →
Q10428 0.996 Q10428 →
Q15173 0.996 Q15173 →
Q28647 0.996 Q28647 →
G5EGS5 0.995 G5EGS5 →
Q66L58 0.995 Q66L58 →
Q2KI89 0.995 Q2KI89 →
Q6I621 0.995 Q6I621 →
Q5R629 0.994 Q5R629 →
Q9ZU97 0.994 Q9ZU97 →
Q84K16 0.993 Q84K16 →
Q6NRQ2 0.993 Q6NRQ2 →
Q68F38 0.993 Q68F38 →