Okadaic Acid

Okadaic Acid

SCHEMBL21408784

C=C1[C@@H](O)C2O[C@]3(CC[C@H](/C=C/[C@@H](C)[C@@H]4CC(C)=C[C@@]5(O[C@H](C[C@@](C)(O)C(=O)O)CC[C@H]5O)O4)O3)CC[C@H]2O[C@@H]1[C@@H](O)C[C@H](C)C1O[C@@]2(CCCCO2)CC[C@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PPM1B O75688 2/20 1.00
PPP2CA P67775 2/20 1.00
PTPN1 P18031 1/20 1.00
PPP1CC P36873 1/20 1.00
TFPI2 P48307 1/20 1.00
NPY4R P50391 1/20 1.00
PPP2R5A Q15172 1/20 1.00
MAPT P10636 1/20 1.00
PPP6C O00743 1/20 1.00
PPP5C P53041 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Okadaic Acid SCHEMBL22024950 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL131485 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL2386832 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL23350437 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL17899362 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL24418495 1.00 PPM1B (1.00) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL545397 0.99 PPM1B (0.99) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL4446706 0.99 PPM1B (0.99) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL29369982 0.99 PPM1B (0.99) PPM1BPPP2CAPTPN1PPP1CCTFPI2
Okadaic Acid SCHEMBL545387 0.99 PPM1B (0.99) PPM1BPPP2CAPTPN1PPP1CCTFPI2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025125890-A1 PROTEIN PHOSPHATASE 2A (PPA2) ANTAGONISTS FOR DENGUE TREATMENT CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL I.P.N. (MX) 2025-06-19 WO disclosed
WO-2024182633-A2 TARGETED DEPHOSPHORYLATION OF TAU THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-09-06 WO disclosed
EP-3773571-A1 PREVENTION OR TREATMENT OF CHRONIC ORGAN INJURY Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin (DE) 2021-02-17 EP disclosed
US-20210008044-A1 PREVENTION OR TREATMENT OF CHRONIC ORGAN INJURY GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN (DE) 2021-01-14 US disclosed
WO-2019185708-A1 PREVENTION OR TREATMENT OF CHRONIC ORGAN INJURY GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN (DE) 2019-10-03 WO disclosed
CN-107028932-A Medicinal usage of the okadaic acid in treatment Periprosthetic bone dissolving 苏州大学附属第医院 2017-08-11 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210008044-A1 PREVENTION OR TREATMENT OF CHRONIC ORGAN INJURY FKBP2, DUSP3, FKBP1A PPM1B 209/4885PPP2CA 21/4885PTPN1 202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.