PRPF6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to PRPF6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Identification of New FTLD Genes	nan	UNKNOWN
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes	nan	RECRUITING
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes	nan	UNKNOWN
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia	nan	RECRUITING
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Cancer in Inherited Bone Marrow Failure Syndromes	nan	RECRUITING
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)	nan	COMPLETED
Biocollection in MyeloDysplastic Syndrome (P-MDS)	nan	RECRUITING
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy	nan	ACTIVE_NOT_RECRUITING
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis	nan	UNKNOWN
Fast Exome for Diagnosis of Congenital Conditions in Infants Under 12 Months of Age Hospitalized in Intensive Care Unit	nan	COMPLETED
SMN Circular RNAs as Potential Biomarkers for the Therapeutic Response to Nusinersen in Spinal Muscular Atrophy Patients	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Genetic Susceptibility to Ankylosing Spondylitis (AS) by Functional Genomics Approach	nan	COMPLETED
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks	nan	RECRUITING
Studying Tissue Samples From Patients With Stage II Colon Cancer Treated on Clinical Trial CLB-9581	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PRPF6 binder may also engage these)

Protein	Name	Similarity
Q5RCC2	—	1.000	Q5RCC2 →
A1A5S1	—	1.000	A1A5S1 →
Q91YR7	—	1.000	Q91YR7 →
Q2KJJ0	—	1.000	Q2KJJ0 →
Q9ZT71	—	1.000	Q9ZT71 →
Q12381	—	1.000	Q12381 →
O74970	—	0.991	O74970 →
Q13099	—	0.990	Q13099 →
Q4PB37	—	0.990	Q4PB37 →
O42668	—	0.990	O42668 →
Q03560	—	0.990	Q03560 →
Q527H0	—	0.989	Q527H0 →
Q7SGD2	—	0.989	Q7SGD2 →
Q9P7R9	—	0.988	Q9P7R9 →
Q23049	—	0.988	Q23049 →
Q6INC1	—	0.988	Q6INC1 →
P19735	—	0.988	P19735 →
O54774	—	0.988	O54774 →
Q24314	—	0.988	Q24314 →
Q6C186	—	0.987	Q6C186 →
SRP72	Signal recognition particle subunit SRP72	0.987	landscape →
Q9ERA6	—	0.987	Q9ERA6 →
B5X0I6	—	0.987	B5X0I6 →
Q5BH69	—	0.987	Q5BH69 →
Q9FG01	—	0.987	Q9FG01 →
Q8CGY6	—	0.987	Q8CGY6 →
Q6CAR6	—	0.987	Q6CAR6 →
O02328	—	0.987	O02328 →
Q22830	—	0.987	Q22830 →
A4UMC5	—	0.986	A4UMC5 →