Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pargyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.96 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | PYCR1 | P32322 | 18/20 | 0.96 |
| ▸ | USP2 | O75604 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pargyline SCHEMBL2045 | 0.98 | PYCR1 (1.00) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Pargyline SCHEMBL18036659 | 0.98 | PYCR1 (1.00) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Pargyline SCHEMBL7363311 | 0.96 | PYCR1 (0.96) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Pargyline SCHEMBL2657939 | 0.91 | PYCR1 (0.86) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Pargyline SCHEMBL4441967 | 0.85 | PYCR1 (0.75) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Pargyline SCHEMBL5981667 | 0.85 | PYCR1 (0.75) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| SCHEMBL11896612 | 0.83 | PYCR1 (0.72) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| SCHEMBL10033796 | 0.82 | PYCR1 (0.71) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Hydrochloric Acid SCHEMBL28077090 | 0.81 | LMNA (0.68) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 | |
| Dibemethine SCHEMBL2139708 | 0.80 | ALDH1A1 (0.67) | LMNAALDH1A1BLMSMN1; SMN2PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2037 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119185270-A | Application of pargyline hydrochloride, metadoxine and dimethyl fumarate compound in preparation of product for inhibiting SpCas9 from binding to or cutting off substrate | 中国人民解放军空军军医大学 | 2024-12-27 | — | — | CN | claimed |
| US-20240245702-A1 | Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells | MASSACHUSETTS EYE AND EAR INFIRMARY | 2024-07-25 | — | — | US | claimed |
| WO-2024028324-A1 | MOLECULES FOR THE PREVENTION AND TREATMENT OF NEUROMUSCULAR DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2024-02-08 | — | — | WO | claimed |
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| CN-114432498-B | Bone repair material and preparation method and application thereof | 北京大学口腔医学院 | 2022-09-23 | — | — | CN | claimed |
| CN-114432498-A | Bone repair material and preparation method and application thereof | 北京大学口腔医学院 | 2022-05-06 | — | — | CN | claimed |
| US-20220008433-A1 | Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells | MASSACHUSETTS EYE AND EAR INFIRMARY | 2022-01-13 | — | — | US | claimed |
| WO-2020213939-A1 | PHARMACEUTICAL COMPOSITION FOR CO-ADMINISTRATION OF ANTICANCER DRUG | 주식회사 진센 | 2020-10-22 | — | — | WO | claimed |
| WO-2020213938-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING SAPONIN AS ACTIVE INGREDIENT | 주식회사 진센 | 2020-10-22 | — | — | WO | claimed |
| WO-2020112883-A1 | INHIBITION OF LYSINE DEMETHYLASE 1 (LSD1) INDUCES DIFFERENTIATION OF HAIR CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2020-06-04 | — | — | WO | claimed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | claimed |
| US-4634716-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1987-01-06 | — | — | US | claimed |
| EP-0079522-B1 | N-CARBOXYMETHYL(AMIDINO)LYSYL-PROLINE ANTIHYPERTENSIVE AGENTS | MERCK & CO. INC. (US) | 1986-05-07 | — | — | EP | claimed |
| US-4584294-A | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents | MERCK & CO., INC. (US) | 1986-04-22 | — | — | US | claimed |
| EP-0166353-A2 | Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | claimed |
| US-4555503-A | ANGIOTENSIN INHIBITORS | MERCK & CO., INC. (US) | 1985-11-26 | — | — | US | claimed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | claimed |
| EP-0107095-A1 | 1-N-alkylcarboxy-benzofused lactams useful as antihypertensive agents | MERCK & CO. INC. (US) | 1984-05-02 | — | — | EP | claimed |
| EP-0081094-A1 | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents | MERCK & CO. INC. (US) | 1983-06-15 | — | — | EP | claimed |
| EP-0079522-A1 | N-Carboxymethyl(amidino)lysyl-proline antihypertensive agents | MERCK & CO. INC. (US) | 1983-05-25 | — | — | EP | claimed |