Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pargyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 5/20 | 0.65 |
| ▸ | MAOA known ✓ | P21397 | 4/20 | 0.65 |
| ▸ | PYCR1 | P32322 | 14/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pargyline SCHEMBL2045 | 0.81 | PYCR1 (1.00) | PYCR1MAOBMAOALMNATSHR | |
| Pargyline SCHEMBL18036659 | 0.81 | PYCR1 (1.00) | PYCR1MAOBMAOALMNATSHR | |
| Pargyline SCHEMBL121111 | 0.79 | LMNA (1.00) | PYCR1MAOBMAOALMNATSHR | |
| Pargyline SCHEMBL7363311 | 0.79 | PYCR1 (0.96) | PYCR1MAOBMAOALMNATSHR | |
| Pargyline SCHEMBL2657939 | 0.78 | PYCR1 (0.86) | PYCR1MAOBMAOALMNATSHR | |
| Pentorex SCHEMBL160519 | 0.73 | TAAR1 (0.44) | LMNAALDH1A1ADRA2AADRA2BADRA2C | |
| Pargyline SCHEMBL5981667 | 0.73 | PYCR1 (0.75) | PYCR1MAOBMAOALMNATSHR | |
| Metyrosine SCHEMBL28832620 | 0.70 | BLM (0.60) | PYCR1MAOBMAOALMNATSHR | |
| Pargyline SCHEMBL4441967 | 0.70 | PYCR1 (0.75) | PYCR1MAOBMAOALMNATSHR | |
| SCHEMBL11896612 | 0.68 | PYCR1 (0.72) | PYCR1MAOBMAOALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11045465-B2 | Methods and compositions to prevent addiction | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20130289061-A1 | METHODS AND COMPOSITIONS TO PREVENT ADDICTION | THE GENERAL HOSPITAL CORPORATION | 2013-10-31 | — | — | US | disclosed |
| WO-2011020030-A9 | METHODS AND COMPOSITIONS TO PREVENT ADDICTION | THE GENERAL HOSPITAL CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011020030-A2 | METHODS AND COMPOSITIONS TO PREVENT ADDICTION | THE GENERAL HOSPITAL CORPORATION (US) | 2011-02-17 | — | — | WO | disclosed |