SDC4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Brigatinib (SCHEMBL11916361)	1.00	1/20
SCHEMBL11916482	0.94	1/20
SCHEMBL11916444	0.94	1/20
SCHEMBL11916541	0.93	1/20
SCHEMBL15207624	0.89	1/20
SCHEMBL11916537	0.88	1/20
SCHEMBL15217787	0.88	1/20
SCHEMBL11916582	0.88	1/20
SCHEMBL11916511	0.88	1/20
SCHEMBL11916532	0.88	1/20
SCHEMBL11916644	0.87	1/20
SCHEMBL11916520	0.87	1/20
SCHEMBL11916443	0.87	1/20
SCHEMBL11916485	0.86	1/20
SCHEMBL15217786	0.86	1/20
SCHEMBL11916418	0.85	1/20
SCHEMBL11916453	0.85	1/20
SCHEMBL11916461	0.85	1/20
SCHEMBL11916474	0.85	1/20
SCHEMBL11916431	0.85	1/20

Clinical trials — most relevant to SDC4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Dexmedetomidine and Total Intravenous Anesthesia on Endothelial Damage-Related Biomarkers	PHASE4	COMPLETED
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation	PHASE4	ACTIVE_NOT_RECRUITING
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)	PHASE2	NOT_YET_RECRUITING
Syndecan-1 a Surrogate Marker for IBD	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Syndecan-4 as a Biomarker in Patients With Chagas Disease	nan	COMPLETED
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients	nan	RECRUITING
Myoglobin Removal With CytoSorb in Rhabdomyolysis	nan	COMPLETED
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy	nan	ACTIVE_NOT_RECRUITING
Albumin, COP and Endothelial Damage in Patients With ESLD Undergoing OLT	nan	COMPLETED
VASCULUX-examination of the Pulmonary VASCUlar Barrier in Patients During LUng Transplantation	nan	UNKNOWN
The Glycocalyx in COVID-19 Patients. A Pilot Study	nan	COMPLETED
Perioperative Plasma Levels of Glycocalyx Markers in Colon Surgery.	nan	UNKNOWN
COronary Microcirculation and Troponin Elevation in Septic Shock	nan	COMPLETED
Alpha-lipoic Acid in Critically Ill Patients With Sepsis	nan	COMPLETED
The FGF/FGFR Signalling Pathway:	nan	COMPLETED
Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx	nan	COMPLETED
Randomized Trial of Fresh Frozen Plasma Versus Albumin in Acute Burn Resuscitation	nan	COMPLETED
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches	nan	UNKNOWN
Cardiogenic Shock Integrated PHenotyping for Event Reduction	nan	RECRUITING
Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy	nan	COMPLETED
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery	nan	COMPLETED
Clinically Actionable Tumor-Associated Antigens in Prostate Cancer	nan	ACTIVE_NOT_RECRUITING
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests	nan	UNKNOWN
Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy	nan	RECRUITING
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient	nan	RECRUITING
Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis	nan	COMPLETED
Mechanisms of Diabetic Nephropathy in Ecuador	nan	SUSPENDED
Gene First Approach to Connective Tissue Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SDC4 binder may also engage these)

Protein	Name	Similarity
Q5RAT9	—	1.000	Q5RAT9 →
P34901	—	1.000	P34901 →
Q8HZJ6	—	1.000	Q8HZJ6 →
P34900	—	0.999	P34900 →
Q6GR51	—	0.999	Q6GR51 →
Q58DD4	—	0.998	Q58DD4 →
O35988	—	0.997	O35988 →
P43407	—	0.996	P43407 →
SDC2	Syndecan-2	0.996	landscape →
P49414	—	0.993	P49414 →
P49416	—	0.992	P49416 →
Q1AGV6	—	0.991	Q1AGV6 →
P50605	—	0.990	P50605 →
B1H3G4	—	0.987	B1H3G4 →
Q5RE35	—	0.987	Q5RE35 →
P31955	—	0.987	P31955 →
Q9BZD6	—	0.986	Q9BZD6 →
Q95M19	—	0.986	Q95M19 →
A1A4K1	—	0.986	A1A4K1 →
Q56A20	—	0.986	Q56A20 →
P10909	—	0.986	P10909 →
Q96FE7	—	0.986	Q96FE7 →
Q9Y5Y7	—	0.986	Q9Y5Y7 →
P14221	—	0.986	P14221 →
Q7TMJ8	—	0.986	Q7TMJ8 →
Q9VPN2	—	0.985	Q9VPN2 →
Q14CH0	—	0.985	Q14CH0 →
Q6P995	—	0.985	Q6P995 →
Q8BGN6	—	0.985	Q8BGN6 →
P58239	—	0.984	P58239 →