SDC2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2179112	0.52	9/20
SCHEMBL2181199	0.76	8/20
SCHEMBL2177896	0.65	8/20
SCHEMBL2177628	0.61	8/20
SCHEMBL1500322	0.59	8/20
SCHEMBL2180951	0.56	8/20
SCHEMBL2180875	0.51	8/20
SCHEMBL7063991	0.49	8/20
SCHEMBL7063999	0.49	8/20
SCHEMBL2181074	0.63	7/20
SCHEMBL7415929	0.60	7/20
SCHEMBL7415930	0.60	7/20
SCHEMBL1500260	0.58	7/20
SCHEMBL1500172	0.55	7/20
SCHEMBL7064833	0.47	7/20
SCHEMBL7064840	0.47	7/20
SCHEMBL1500196	0.57	6/20
SCHEMBL2176682	0.56	6/20
SCHEMBL2176688	0.56	6/20
SCHEMBL8141859	0.55	6/20

Clinical trials — most relevant to SDC2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Dexmedetomidine and Total Intravenous Anesthesia on Endothelial Damage-Related Biomarkers	PHASE4	COMPLETED
Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects	PHASE4	COMPLETED
Intratumoral Injection of Autologous CD1c (BDCA-1)+ MyDC, Avelumab, and Ipilimumab Plus Systemic Nivolumab	PHASE1/PHASE2	RECRUITING
The Synapse Project	PHASE2	COMPLETED
Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)	PHASE2	NOT_YET_RECRUITING
CD19 and CD22 Dual-targeted CAR-T Cells for Relapsed or Refractory B-NHL	EARLY_PHASE1	UNKNOWN
Syndecan-1 a Surrogate Marker for IBD	nan	COMPLETED
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients	nan	RECRUITING
The Glycocalyx in COVID-19 Patients. A Pilot Study	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Myoglobin Removal With CytoSorb in Rhabdomyolysis	nan	COMPLETED
VASCULUX-examination of the Pulmonary VASCUlar Barrier in Patients During LUng Transplantation	nan	UNKNOWN
Cardiogenic Shock Integrated PHenotyping for Event Reduction	nan	RECRUITING
Perioperative Plasma Levels of Glycocalyx Markers in Colon Surgery.	nan	UNKNOWN
The FGF/FGFR Signalling Pathway:	nan	COMPLETED
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy	nan	ACTIVE_NOT_RECRUITING
Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy	nan	COMPLETED
Syndecan-4 as a Biomarker in Patients With Chagas Disease	nan	COMPLETED
Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx	nan	COMPLETED
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery	nan	COMPLETED
Genetic Identification (ID) of Segmental Dysplastic Nevi	nan	WITHDRAWN
COronary Microcirculation and Troponin Elevation in Septic Shock	nan	COMPLETED
Clinically Actionable Tumor-Associated Antigens in Prostate Cancer	nan	ACTIVE_NOT_RECRUITING
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient	nan	RECRUITING
Alpha-lipoic Acid in Critically Ill Patients With Sepsis	nan	COMPLETED
Randomized Trial of Fresh Frozen Plasma Versus Albumin in Acute Burn Resuscitation	nan	COMPLETED
Descriptive Analysis of Surgeries in Patients With Multiple Osteochondromas	nan	RECRUITING
Natural History Study of Children With LAMA2-related Dystrophies	nan	RECRUITING
Biomarkers of Lichen Sclerosus	nan	UNKNOWN
Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SDC2 binder may also engage these)

Protein	Name	Similarity
Q58DD4	—	1.000	Q58DD4 →
Q6GR51	—	1.000	Q6GR51 →
P34900	—	1.000	P34900 →
P43407	—	1.000	P43407 →
Q5RAT9	—	1.000	Q5RAT9 →
P49414	—	0.998	P49414 →
SDC4	Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan co	0.997	landscape →
P50605	—	0.997	P50605 →
P34901	—	0.996	P34901 →
Q8HZJ6	—	0.994	Q8HZJ6 →
P49416	—	0.993	P49416 →
O35988	—	0.991	O35988 →
B1H3G4	—	0.990	B1H3G4 →
Q5RE35	—	0.990	Q5RE35 →
AREG	Amphiregulin	0.989	landscape →
Q1AGV6	—	0.989	Q1AGV6 →
P31955	—	0.989	P31955 →
Q9Y5Y7	—	0.989	Q9Y5Y7 →
P26261	—	0.987	P26261 →
A1A4K1	—	0.987	A1A4K1 →
Q95M19	—	0.987	Q95M19 →
Q9DC11	—	0.986	Q9DC11 →
Q9BZD6	—	0.986	Q9BZD6 →
A6QP06	—	0.986	A6QP06 →
Q14CH0	—	0.986	Q14CH0 →
Q10651	—	0.986	Q10651 →
Q8R1R5	—	0.985	Q8R1R5 →
P14221	—	0.985	P14221 →
Q6P995	—	0.985	Q6P995 →
P24338	—	0.985	P24338 →