SENP8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL61076	0.52	4/20
SCHEMBL61077	0.52	4/20
SCHEMBL66528	0.52	4/20
SCHEMBL122581	0.58	3/20
SCHEMBL59246	0.47	3/20
SCHEMBL36613	1.00	2/20
SCHEMBL107774	1.00	2/20
SCHEMBL108116	0.78	2/20
SCHEMBL120325	0.77	2/20
SCHEMBL122823	0.77	2/20
SCHEMBL120447	0.74	2/20
SCHEMBL118478	0.71	2/20
SCHEMBL121310	0.70	2/20
SCHEMBL119629	0.69	2/20
SCHEMBL66273	0.68	2/20
SCHEMBL120441	0.68	2/20
SCHEMBL123187	0.68	2/20
SCHEMBL119329	0.67	2/20
SCHEMBL108264	0.63	2/20
SCHEMBL118917	0.62	2/20

Clinical trials — most relevant to SENP8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer	PHASE1/PHASE2	COMPLETED
Studying TAK-243 in Patients With Advanced Cancer	PHASE1	RECRUITING
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Evaluation of Prognostic Factors: From Breast Cancer to Bone Metastases	nan	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Autophagy Bladder Cancer	nan	UNKNOWN
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
CRE8 in All Comers Patients	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm	nan	COMPLETED
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
Pathogenetic Basis of Aortopathy and Aortic Valve Disease	nan	ACTIVE_NOT_RECRUITING
Identification of New FTLD Genes	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Genetic Basis of Abdominal Aortic Aneurysm	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SENP8 binder may also engage these)

Protein	Name	Similarity
Q9D2Z4	—	1.000	Q9D2Z4 →
Q5FVJ8	—	0.996	Q5FVJ8 →
Q9LSS7	—	0.987	Q9LSS7 →
Q4I2W2	—	0.973	Q4I2W2 →
P42348	—	0.971	P42348 →
NAT10	RNA cytidine acetyltransferase	0.971	landscape →
Q7RZA2	—	0.970	Q7RZA2 →
Q68EH8	—	0.970	Q68EH8 →
P00927	—	0.970	P00927 →
Q29FC9	—	0.970	Q29FC9 →
Q4VSI4	—	0.970	Q4VSI4 →
USP7	Ubiquitin carboxyl-terminal hydrolase 7	0.969	landscape →
Q27597	—	0.969	Q27597 →
B3P4N5	—	0.969	B3P4N5 →
Q9I8E6	—	0.968	Q9I8E6 →
P93648	—	0.968	P93648 →
Q28IV6	—	0.968	Q28IV6 →
Q8CHC4	—	0.968	Q8CHC4 →
O94609	—	0.968	O94609 →
A8WK63	—	0.968	A8WK63 →
Q7ZWC4	—	0.968	Q7ZWC4 →
ELP1	Elongator complex protein 1	0.968	landscape →
Q6U7I1	—	0.968	Q6U7I1 →
P0DW59	—	0.968	P0DW59 →
Q9LPT6	—	0.968	Q9LPT6 →
P25840	—	0.968	P25840 →
LIG4	DNA ligase 4	0.968	landscape →
P42339	—	0.967	P42339 →
Q29LW1	—	0.967	Q29LW1 →
P24785	—	0.967	P24785 →