Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.52 |
| ▸ | ATIC | P31939 | 4/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.51 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.51 |
| ▸ | GART | P22102 | 10/20 | 0.51 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.47 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.47 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.47 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044214 | 0.94 | DHFR (0.46) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9045940 | 0.89 | ATIC (0.47) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9046824 | 0.88 | ATIC (0.55) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9342476 | 0.88 | ATIC (0.48) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9045385 | 0.87 | FOLR2 (0.51) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9043298 | 0.87 | FOLR1 (0.48) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9044667 | 0.86 | ATIC (0.49) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9044516 | 0.85 | ATIC (0.52) | ATICSHMT1SHMT2GARTFOLR2 | |
| SCHEMBL9044131 | 0.85 | GART (0.50) | DHFRATICSHMT1SHMT2GART | |
| SCHEMBL9049515 | 0.84 | CA2 (0.44) | DHFRATICSHMT1SHMT2GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066463-A1 | SOLID FORMS OF PEMETREXED | DR. REDDY'S LABORATORIES, INC. (US) | 2014-03-06 | — | — | US | claimed |
| US-20100063072-A1 | SOLID FORMS OF PEMETREXED | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-03-11 | — | — | US | claimed |
| EP-2129674-A2 | SOLID FORMS OF PEMETREXED | Dr. Reddy's Laboratories Ltd. (IN) | 2009-12-09 | — | — | EP | claimed |
| WO-2008124485-A2 | SOLID FORMS OF PEMETREXED | DR. REDDY'S LABORATORIES LTD. (IN) | 2008-10-16 | — | — | WO | claimed |
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | claimed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | claimed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | claimed |
| EP-3021849-B1 | NOVEL CRYSTALLINE FORMS OF PEMETREXED TROMETHAMINE SALTS | Dr Reddys Laboratories Ltd (IN) | 2019-10-09 | — | — | EP | disclosed |
| EP-2293795-B1 | Pharmaceutical combination | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| US-20140066463-A1 | SOLID FORMS OF PEMETREXED | DR. REDDY'S LABORATORIES, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-8507508-B2 | Solid forms of pemetrexed | DR. REDDY'S LABORATORIES LIMITED (IN) | 2013-08-13 | — | — | US | disclosed |
| WO-2012017443-A1 | PROCESS FOR PREPARATION OF HIGHLY PURE DIALKYL PEMETREXED | NEON LABORATORIES LTD. (IN) | 2012-02-09 | — | — | WO | disclosed |
| EP-2129674-A2 | SOLID FORMS OF PEMETREXED | Dr. Reddy's Laboratories Ltd. (IN) | 2009-12-09 | — | — | EP | disclosed |
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| CN-1030608-C | N-(pyrrolo {2,3-d} pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-01-03 | — | — | CN | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066463-A1 | SOLID FORMS OF PEMETREXED | TYMP, TYMS, HPRT1 | DHFR 10/4885ATIC 315/4885SHMT1 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.