SLC25A6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4942072	0.52	2/20
Gilteritinib (SCHEMBL282229)	1.00	1/20
Masitinib (SCHEMBL717239)	1.00	1/20
SCHEMBL328303	0.94	1/20
Masitinib (SCHEMBL1096348)	0.94	1/20
Masitinib (SCHEMBL2297143)	0.94	1/20
SCHEMBL3301373	0.91	1/20
SCHEMBL10156928	0.89	1/20
SCHEMBL16085058	0.89	1/20
SCHEMBL717173	0.88	1/20
SCHEMBL717184	0.87	1/20
SCHEMBL4828703	0.86	1/20
SCHEMBL715882	0.85	1/20
SCHEMBL715899	0.85	1/20
SCHEMBL282490	0.85	1/20
SCHEMBL282491	0.85	1/20
SCHEMBL715940	0.85	1/20
SCHEMBL6241566	0.85	1/20
SCHEMBL5515053	0.84	1/20
SCHEMBL14286281	0.84	1/20

Clinical trials — most relevant to SLC25A6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults	EARLY_PHASE1	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease	nan	NOT_YET_RECRUITING
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)	nan	UNKNOWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Muscle OXPHOS and Nutrient Homeostasis	nan	COMPLETED
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Genetic Diagnosis in Inborn Errors of Metabolism	nan	ENROLLING_BY_INVITATION
Mitoquines in COPD	nan	UNKNOWN
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2	nan	UNKNOWN
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI	nan	UNKNOWN
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency	nan	NO_LONGER_AVAILABLE
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC25A6 binder may also engage these)

Protein	Name	Similarity
P32007	—	1.000	P32007 →
P51881	—	1.000	P51881 →
Q6QRN9	—	1.000	Q6QRN9 →
Q5R5A1	—	1.000	Q5R5A1 →
Q8SQH5	—	1.000	Q8SQH5 →
SLC25A5	ADP/ATP translocase 2	1.000	landscape →
P02722	—	1.000	P02722 →
Q09073	—	1.000	Q09073 →
SLC25A4	ADP/ATP translocase 1	1.000	landscape →
Q000K2	—	1.000	Q000K2 →
Q05962	—	0.999	Q05962 →
P48962	—	0.998	P48962 →
O46373	—	0.997	O46373 →
F1R4U0	—	0.961	F1R4U0 →
SLC25A11	Mitochondrial 2-oxoglutarate/malate carrier protein	0.953	landscape →
Q27238	—	0.953	Q27238 →
P97700	—	0.953	P97700 →
Q7PQV7	—	0.952	Q7PQV7 →
P32089	—	0.946	P32089 →
SLC25A1	Tricarboxylate transport protein, mitochondrial	0.945	landscape →
P79110	—	0.943	P79110 →
P22292	—	0.941	P22292 →
Q9CR62	—	0.940	Q9CR62 →
Q8JZU2	—	0.940	Q8JZU2 →
SLC25A20	Mitochondrial carnitine/acylcarnitine carrier protein	0.940	landscape →
Q26365	—	0.938	Q26365 →
Q9CR58	—	0.935	Q9CR58 →
Q8HXY2	—	0.934	Q8HXY2 →
O95258	—	0.933	O95258 →
O97649	—	0.930	O97649 →