SLC25A5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL353367	1.00	2/20
SCHEMBL4357878	1.00	2/20
SCHEMBL10896508	0.96	2/20
Valine (SCHEMBL11879553)	0.75	2/20
SCHEMBL9149194	0.69	2/20
SCHEMBL15976145	0.64	2/20
SCHEMBL11451081	0.59	2/20
SCHEMBL9512613	0.57	2/20
SCHEMBL11698893	0.57	2/20
SCHEMBL2112664	0.55	2/20
SCHEMBL8893921	0.55	2/20
SCHEMBL435148	0.50	2/20
SCHEMBL6958511	0.50	2/20
SCHEMBL7823572	0.50	2/20
Diphenadione (SCHEMBL43891)	0.47	2/20
SCHEMBL9431982	0.47	2/20
Diphenadione (SCHEMBL1651307)	0.46	2/20
SCHEMBL4811658	0.45	2/20
SCHEMBL7145735	0.45	2/20
SCHEMBL8604882	0.45	2/20

Clinical trials — most relevant to SLC25A5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease	nan	NOT_YET_RECRUITING
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)	nan	UNKNOWN
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2	nan	UNKNOWN
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle	nan	NOT_YET_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Mitoquines in COPD	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
Mitochondrial Dysfunction in Phelan-McDermid Syndrome	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Identification and Characterization of Monogenic Diabetes	nan	COMPLETED
Effect of Hypothyroidism on Brown Adipose Tissue	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC25A5 binder may also engage these)

Protein	Name	Similarity
P51881	—	1.000	P51881 →
Q5R5A1	—	1.000	Q5R5A1 →
Q8SQH5	—	1.000	Q8SQH5 →
Q09073	—	1.000	Q09073 →
SLC25A6	ADP/ATP translocase 3	1.000	landscape →
P32007	—	1.000	P32007 →
SLC25A4	ADP/ATP translocase 1	1.000	landscape →
Q6QRN9	—	1.000	Q6QRN9 →
Q000K2	—	1.000	Q000K2 →
P02722	—	1.000	P02722 →
Q05962	—	0.998	Q05962 →
P48962	—	0.997	P48962 →
O46373	—	0.996	O46373 →
F1R4U0	—	0.960	F1R4U0 →
P97700	—	0.952	P97700 →
SLC25A11	Mitochondrial 2-oxoglutarate/malate carrier protein	0.952	landscape →
Q27238	—	0.947	Q27238 →
Q7PQV7	—	0.946	Q7PQV7 →
P32089	—	0.946	P32089 →
SLC25A1	Tricarboxylate transport protein, mitochondrial	0.945	landscape →
Q9CR62	—	0.943	Q9CR62 →
P79110	—	0.942	P79110 →
Q8JZU2	—	0.940	Q8JZU2 →
P22292	—	0.939	P22292 →
SLC25A20	Mitochondrial carnitine/acylcarnitine carrier protein	0.937	landscape →
Q9CR58	—	0.934	Q9CR58 →
Q26365	—	0.934	Q26365 →
Q8HXY2	—	0.933	Q8HXY2 →
O95258	—	0.930	O95258 →
O97649	—	0.928	O97649 →