Sugi Predict
/ Targets
/ STK33
Top predicted compounds (top 20 by supporting neighbours, then confidence)
Clinical trials — most relevant to STK33 by text similarity (a relevance ranking, not an exhaustive list)
| Trial | Phase | Status |
|---|
| Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions |
PHASE4 | UNKNOWN |
| Signal TrAnsduction Pathway Activity Analysis in OVarian cancER |
PHASE2/PHASE3 | RECRUITING |
| The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus |
PHASE3 | UNKNOWN |
| Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial) |
PHASE2 | COMPLETED |
| Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion |
PHASE2 | ACTIVE_NOT_RECRUITING |
| Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation. |
PHASE2 | ACTIVE_NOT_RECRUITING |
| I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers |
PHASE1/PHASE2 | NOT_YET_RECRUITING |
| Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus |
PHASE2 | COMPLETED |
| Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations |
PHASE2 | COMPLETED |
| Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients |
PHASE2 | COMPLETED |
| A Phase II Study of Dasatinib in the Treatment of Relapsed or Plateau Phase Multiple Myeloma |
PHASE2 | COMPLETED |
| A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas |
PHASE2 | SUSPENDED |
| A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H... |
PHASE2 | COMPLETED |
| Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma |
PHASE2 | ACTIVE_NOT_RECRUITING |
| Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors |
PHASE1 | RECRUITING |
| A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b |
PHASE1 | COMPLETED |
| AZD1775 for Advanced Solid Tumors |
PHASE1 | COMPLETED |
| Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma |
PHASE1 | COMPLETED |
| Study of ACC-1898 in Adult Participants With Advanced Solid Tumors |
PHASE1 | NOT_YET_RECRUITING |
| Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer |
EARLY_PHASE1 | COMPLETED |
| Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 |
EARLY_PHASE1 | COMPLETED |
| New Genes in the Carcinogenesis of Colorectal Cancer |
nan | UNKNOWN |
| SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases |
nan | NOT_YET_RECRUITING |
| Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus |
nan | COMPLETED |
| Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation |
nan | COMPLETED |
| Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children |
nan | COMPLETED |
| Protein Intake and Step Reduction in Older Adults |
nan | COMPLETED |
| Identification of Novel Targetable Kinases in SR-a GvHD |
nan | COMPLETED |
| Biomarker Analysis of Gastrointestinal Cancer |
nan | UNKNOWN |
| NTRK 1,2,3 Rearrangements in Patients With Solid Tumors |
nan | ACTIVE_NOT_RECRUITING |
Related proteins — ESM-2 sequence neighbours (a STK33 binder may also engage these)