Pyrvinium

Pyrvinium

SCHEMBL149063

Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 1.00
SYNJ2 O15056 1/20 1.00
MLNR O43193 1/20 1.00
SYNJ1 O43426 1/20 1.00
PGR P06401 1/20 1.00
ADRB1 P08588 1/20 1.00
ADRA2A P08913 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD2 P14416 1/20 1.00
ADRA2B P18089 1/20 1.00
CHRM3 P20309 1/20 1.00
MAOA P21397 1/20 1.00
CNR1 P21554 1/20 1.00
TBXA2R P21731 1/20 1.00
SLC6A2 P23975 1/20 1.00
NPY1R P25929 1/20 1.00
HTR2C P28335 1/20 1.00
ADORA2A P29274 1/20 1.00
BDKRB2 P30411 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrvinium SCHEMBL30383133 1.00 AR (1.00) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL149062 1.00 AR (1.00) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL16291465 1.00 AR (1.00) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL30642307 1.00 AR (1.00) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL29387513 1.00 AR (1.00) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL21111996 0.99 AR (0.98) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL646420 0.99 AR (0.98) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL646419 0.99 AR (0.98) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL4877919 0.94 AR (0.89) ARSYNJ2MLNRSYNJ1PGR
Pyrvinium SCHEMBL4881741 0.94 AR (0.89) ARSYNJ2MLNRSYNJ1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1093 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122024819-A Method for screening atopic dermatitis key autophagy genes based on transcriptome and machine learning 常德市第一人民医院 2026-05-12 CN claimed
US-20260108480-A1 METHODS FOR INDUCING PROLIFERATION OF STEM CELLS UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) 2026-04-23 US claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
US-12570956-B2 Efficient derivation of stable pluripotent bovine embryonic stem cells THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-03-10 US claimed
WO-2025264721-A1 ENHANCEMENT OF REGENERATIVE ACTIVITY BY INACTIVATION OF SENESCENT CELLS IMMORTA BIO, INC. (US) 2025-12-26 WO claimed
US-12447147-B2 Methods of treating, ameliorating, and/or preventing cancer using pyrvinium compositions THOMAS JEFFERSON UNIVERSITY (US) 2025-10-21 US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
EP-3976197-B1 THERAPEUTICS AND METHODS FOR PREDICTING AND OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER LUNELLA BIOTECH INC (CA) 2025-07-16 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12295957-B2 Ascorbic acid and quinone compounds in combination with an antiparasitic agent for treating a parasitic disease IC-MedTech Corp. (US) 2025-05-13 US claimed
WO-2008150845-A1 SCREENING FOR WNT PATHWAY MODULATORS AND PYRVINIUM FOR THE TREATMENT OF CANCE VANDERBILT UNIVERSITY (US) 2008-12-11 WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1883452-A2 PHARMACEUTICAL COMPOSITION CONTAINING AN ANTI PARASITIC AGENT AND AN ACTIVE INGREDIENT SELECTED FROM CARVEOL, THYMOL, EUGENOL, BORNEOL, CARVACROL, ALPHA-IONONE, OR BETA-IONONE ASD (Advanced Scientific Developments) (MA) 2008-02-06 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2006120568-A2 PHARMACEUTICAL COMPOSITION CONTAINING AN ANTI PARASITIC AGENT AND AN ACTIVE INGREDIENT SELECTED FROM CARVEOL, THYMOL, EUGENOL, BORNEOL, CARVACROL, ALPHA-IONONE, OR BETA-IONONE ADVANCED SCIENTIFIC DEVELOPEMENTS (MA) 2006-11-16 WO claimed
WO-2006120495-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIVIRAL AGENT, AN ANTITUMOUR AGENT OR AN ANTIPARASITIC AGENT AND AN ACTIVE SUBSTANCE SELECTED FROM CARVEOL, THYMOL, EUGENOL, BORNEOL AND CARVACROL ADVANCED SCIENTIFIC DEVELOPEMENTS (MA) 2006-11-16 WO claimed
US-20060252049-A1 Growth-promoting and immunizing subcutaneous implant IVY ANIMAL HEALTH, INC. 2006-11-09 US claimed
EP-0507629-B1 Sustained release capsule and formulations for insertion into rumen LILLY CO ELI (US) 1997-01-22 EP claimed
EP-0080341-B1 PHARMACEUTICAL MULTIPLE-UNITS FORMULATION A/S Alfred Benzon (DK) 1987-10-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12447147-B2 Methods of treating, ameliorating, and/or preventing cancer using pyrvinium compositions RNASE1, PDXK, PNLIP AR 1717/4885SYNJ2 4226/4885MLNR 872/4885
US-20260108480-A1 METHODS FOR INDUCING PROLIFERATION OF STEM CELLS CYP4X1, SLC6A7, ZFX AR 2055/4885SYNJ2 2411/4885MLNR 3960/4885
US-12570956-B2 Efficient derivation of stable pluripotent bovine embryonic stem cells WNT1, PHKA1, ACVR1 AR 3905/4885SYNJ2 1063/4885MLNR 2684/4885
US-12295957-B2 Ascorbic acid and quinone compounds in combination with an antiparasitic agent for treating a parasitic disease NQO1, ADH7, CYP27B1 AR 4427/4885SYNJ2 3303/4885MLNR 1427/4885
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER ATP5ME, MT-ATP6, ATP5MK AR 3084/4885SYNJ2 3475/4885MLNR 1585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.