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Sugi Predict / Targets / TCF7L2

TCF7L2

Transcription factor 7-like 2 (HMG box transc · Q9NQB0 · TCF7L2 on Sugi Atlas →

9,469 patent compounds predicted against TCF7L2, 4,755 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL940639 SCHEMBL940639 0.51 20/20
SCHEMBL1391417 SCHEMBL1391417 0.50 18/20
SCHEMBL1391817 SCHEMBL1391817 0.51 17/20
SCHEMBL2257676 SCHEMBL2257676 0.54 15/20
SCHEMBL2263166 SCHEMBL2263166 0.55 14/20
SCHEMBL1298474 SCHEMBL1298474 0.52 14/20
SCHEMBL1009665 SCHEMBL1009665 0.46 14/20
SCHEMBL1391822 SCHEMBL1391822 0.54 11/20
SCHEMBL2808009 SCHEMBL2808009 0.52 11/20
SCHEMBL2260475 SCHEMBL2260475 0.49 10/20
SCHEMBL1650919 SCHEMBL1650919 0.45 10/20
SCHEMBL1721257 SCHEMBL1721257 0.51 9/20
SCHEMBL29019 SCHEMBL29019 0.47 9/20
SCHEMBL1010102 SCHEMBL1010102 0.46 9/20
SCHEMBL1392146 SCHEMBL1392146 0.44 8/20
SCHEMBL1622067 SCHEMBL1622067 0.35 8/20
SCHEMBL1622070 SCHEMBL1622070 0.35 8/20
SCHEMBL1624156 SCHEMBL1624156 0.34 8/20
SCHEMBL1624158 SCHEMBL1624158 0.34 8/20
SCHEMBL1202080 SCHEMBL1202080 0.43 7/20

Clinical trials — most relevant to TCF7L2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Mechanisms of Lipodystrophy in HIV-Infected Pateints PHASE4COMPLETED
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans PHASE2NOT_YET_RECRUITING
PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications PHASE1/PHASE2RECRUITING
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma PHASE1COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission? EARLY_PHASE1UNKNOWN
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms nanCOMPLETED
Genetics of Insulin and Incretins in Cystic Fibrosis nanRECRUITING
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION nanRECRUITING
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy nanNOT_YET_RECRUITING
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes nanCOMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells nanCOMPLETED
Epidemiological and Genetic Studies of Body Mass Index nanCOMPLETED
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma nanUNKNOWN
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone. nanCOMPLETED
Study to Investigate Adipocyte Cell and Lipid Turnover in Obese Adolescents nanCOMPLETED
Epithelial Mesenchymal Transition and Periodontitis nanUNKNOWN
Transcriptomic Responses for the Identification of Pathogens nanRECRUITING
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Zn Supplementation in HIV Immunological Non Responders nanRECRUITING
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients nanUNKNOWN
EKLF Gene Expression in β-thalassemia nanNOT_YET_RECRUITING
Cause of Familial Testicular Cancer nanCOMPLETED
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors nanUNKNOWN
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation nanCOMPLETED
Model to Predict pCR and IrAEs in Early Stage Non-small Cell Lung Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TCF7L2 binder may also engage these)

ProteinNameSimilarity
Q924A0 — 0.997 Q924A0 →
Q9HCS4 — 0.996 Q9HCS4 →
Q9Z1J1 — 0.995 Q9Z1J1 →
Q90ZB6 — 0.994 Q90ZB6 →
P70062 — 0.994 P70062 →
Q80TZ9 — 0.993 Q80TZ9 →
Q91904 — 0.993 Q91904 →
O55170 — 0.993 O55170 →
Q9YGK8 — 0.993 Q9YGK8 →
Q04888 — 0.993 Q04888 →
Q9QXN1 — 0.993 Q9QXN1 →
P23899 — 0.993 P23899 →
P40645 — 0.992 P40645 →
LEF1 Lymphoid enhancer-binding factor 1 0.992 landscape →
O09100 — 0.992 O09100 →
Q62901 — 0.992 Q62901 →
Q58NQ4 — 0.992 Q58NQ4 →
P70284 — 0.992 P70284 →
Q91907 — 0.992 Q91907 →
P19091 — 0.992 P19091 →
P61753 — 0.992 P61753 →
Q9BG89 — 0.992 Q9BG89 →
P48436 — 0.992 P48436 →
Q9H334 — 0.992 Q9H334 →
Q0VGT2 — 0.992 Q0VGT2 →
Q499D0 — 0.992 Q499D0 →
Q800Q5 — 0.992 Q800Q5 →
P23770 — 0.992 P23770 →
Q91660 — 0.992 Q91660 →
P54655 — 0.991 P54655 →