THOP1

Thimet oligopeptidase · P52888 · THOP1 on Sugi Atlas →

0 patent compounds predicted against THOP1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to THOP1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRADE-Testosterone Replacement and Dutasteride Effectiveness PHASE4COMPLETED
Study of Thyroid Hormones in Prematures PHASE3WITHDRAWN
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome) PHASE2/PHASE3UNKNOWN
Efficacy of Candesartan on Symptomatic Heart Failure in Treating Diabetic and Hypertensive Patients. PHASE3COMPLETED
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities PHASE2COMPLETED
Thyroid and Glucose and Energy Metabolism PHASE2COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism nanUNKNOWN
EEG Alterations in Preterm Infants With Thyroid Dysfunction nanCOMPLETED
Pharmacodynamics of CNP During Growth Hormone Treatment nanCOMPLETED
Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome nanUNKNOWN
A Study of Selenomethionine and Myo-inositol(SOLOWAYS_TM) in Patients With Autoimmune Thyroiditis Carrying the DIO2 Thr92Ala Polymorphism nanCOMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3 nanCOMPLETED
Thyroid Hormones in CKD nanNOT_YET_RECRUITING
Thyroid and Cortisol Hormone Response to Sepsis nanNOT_YET_RECRUITING
Ovarian Reserve and Matrix Metalloproteinases nanCOMPLETED
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency nanCOMPLETED
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment nanCOMPLETED
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine nanRECRUITING
Residual Renal Function Preservation in Peritoneal Dialysis Patients nanUNKNOWN
Interval Training and Hormones in Chronic Heart Failure nanUNKNOWN
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation nanUNKNOWN
Reproductive Aging and Obstructive Sleep Apnea nanWITHDRAWN
The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications nanCOMPLETED
Molecular Basis of the Growth Axis in Short Stature nanCOMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies nanCOMPLETED
Thyroid and Adrenal Disorders in ICU nanNOT_YET_RECRUITING
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage nanENROLLING_BY_INVITATION
Polymorphisms in the Vitamin D System and Health nanCOMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a THOP1 binder may also engage these)

ProteinNameSimilarity
Q1JPJ8 1.000 Q1JPJ8 →
P47788 0.997 P47788 →
Q8C1A5 0.994 Q8C1A5 →
P24155 0.990 P24155 →
A6H611 0.973 A6H611 →
Q99797 0.970 Q99797 →
Q01992 0.967 Q01992 →
Q5RF14 0.967 Q5RF14 →
A2VDQ5 0.965 A2VDQ5 →
P42676 0.963 P42676 →
Q91YP2 0.963 Q91YP2 →
P42675 0.956 P42675 →
O09175 0.955 O09175 →
O95671 0.954 O95671 →
RNPEP Aminopeptidase B 0.953 landscape →
P25409 0.953 P25409 →
Q8VCT3 0.953 Q8VCT3 →
Q8QZR5 0.952 Q8QZR5 →
P08836 0.952 P08836 →
P24298 0.952 P24298 →
Q02038 0.952 Q02038 →
A4IFH5 0.951 A4IFH5 →
Q5R514 0.951 Q5R514 →
P13439 0.950 P13439 →
FDPS Farnesyl pyrophosphate synthase 0.950 landscape →
NLN Neurolysin, mitochondrial 0.949 landscape →
Q14CH1 0.946 Q14CH1 →
LPCAT1 Lysophosphatidylcholine acyltransferase 1 0.946 landscape →
UMPS Uridine 5'-monophosphate synthase 0.946 landscape →
Q8BGT5 0.945 Q8BGT5 →