TLL2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16898049	1.00	3/20
SCHEMBL16898088	1.00	3/20
SCHEMBL16898091	1.00	3/20
SCHEMBL16898102	1.00	3/20
SCHEMBL16898105	1.00	3/20
SCHEMBL16898346	1.00	3/20
SCHEMBL16898435	1.00	3/20
SCHEMBL16898120	0.91	3/20
SCHEMBL16898122	0.91	3/20
SCHEMBL16898416	0.89	3/20
SCHEMBL16898418	0.89	3/20
SCHEMBL16898383	0.88	3/20
SCHEMBL16898386	0.88	3/20
SCHEMBL16898037	0.88	3/20
SCHEMBL16898040	0.88	3/20
SCHEMBL16898045	0.85	3/20
SCHEMBL16898047	0.85	3/20
SCHEMBL18241244	0.85	3/20
SCHEMBL18241246	0.85	3/20
SCHEMBL16898599	0.84	3/20

Clinical trials — most relevant to TLL2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of GLA on Human Volunteers	PHASE1	COMPLETED
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers	nan	COMPLETED
Epidemiological and Genetic Studies of Body Mass Index	nan	COMPLETED
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population	nan	RECRUITING
Acute Effect of Intensive Insulin Infusion on Intestinal Triglyceride-rich-lipoprotein-apoB48 Metabolism in Type 2 Diabetic Patients	nan	COMPLETED
TL1A Expression in Psoriatic Skin	nan	UNKNOWN
MicroRNAs and Cytokines in Peri-Implantitis Tissue	nan	UNKNOWN
Immune Cell Response to Stimuli	nan	RECRUITING
Imaging Genetics of Laryngeal Dystonia	nan	RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma	nan	COMPLETED
Natural History of HPV From Infection to Neoplasia in Adolescents and Young Women	nan	COMPLETED
Studies on the Expression and Functions of RLIP76 in Blood Samples of Healthy Human Subjects	nan	WITHDRAWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism	nan	UNKNOWN
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION	nan	RECRUITING
Expression of Inflammatory Proteins in Pancreatic Cancer	nan	UNKNOWN
Anti-inflammatory Effects of Fiber	nan	COMPLETED
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis	nan	COMPLETED
Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis	nan	RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Attenuation of Postprandial Inflammatory Processes in Alzheimer's Disease Patients by Consumption of Pomace Oil	nan	ACTIVE_NOT_RECRUITING
Gene-Specific Responses to Exercise in Discordant Twins	nan	COMPLETED
Serum NGAL IN Patients With Multiple Myeloma	nan	UNKNOWN
TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP)	nan	NOT_YET_RECRUITING
Family Studies in Primary Biliary Cirrhosis (PBC)	nan	UNKNOWN
Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic Leukemia	nan	COMPLETED
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)	nan	RECRUITING
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.	nan	RECRUITING
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TLL2 binder may also engage these)

Protein	Name	Similarity
Q9WVM6	—	1.000	Q9WVM6 →
P98063	—	1.000	P98063 →
Q62381	—	1.000	Q62381 →
O57460	—	1.000	O57460 →
BMP1	Bone morphogenetic protein 1	1.000	landscape →
O57382	—	1.000	O57382 →
Q20176	—	1.000	Q20176 →
TLL1	Tolloid-like protein 1	1.000	landscape →
Q9DER7	—	1.000	Q9DER7 →
Q8JI28	—	0.995	Q8JI28 →
P98070	—	0.993	P98070 →
Q5R544	—	0.993	Q5R544 →
Q4R577	—	0.992	Q4R577 →
P25723	—	0.992	P25723 →
P98069	—	0.991	P98069 →
Q5R1W3	—	0.991	Q5R1W3 →
Q8CG16	—	0.990	Q8CG16 →
Q5G265	—	0.989	Q5G265 →
D5FM34	—	0.989	D5FM34 →
ST14	Suppressor of tumorigenicity 14 protein	0.988	landscape →
P56677	—	0.987	P56677 →
Q95220	—	0.987	Q95220 →
P53690	—	0.987	P53690 →
Q8CFG9	—	0.986	Q8CFG9 →
Q8CFG8	—	0.986	Q8CFG8 →
Q5G270	—	0.986	Q5G270 →
Q5G266	—	0.986	Q5G266 →
F1RWC3	—	0.985	F1RWC3 →
P50757	—	0.985	P50757 →
Q10739	—	0.985	Q10739 →