TLL1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16898049	1.00	3/20
SCHEMBL16898088	1.00	3/20
SCHEMBL16898091	1.00	3/20
SCHEMBL16898102	1.00	3/20
SCHEMBL16898105	1.00	3/20
SCHEMBL16898346	1.00	3/20
SCHEMBL16898435	1.00	3/20
SCHEMBL16898120	0.91	3/20
SCHEMBL16898122	0.91	3/20
SCHEMBL16898416	0.89	3/20
SCHEMBL16898418	0.89	3/20
SCHEMBL16898383	0.88	3/20
SCHEMBL16898386	0.88	3/20
SCHEMBL16898037	0.88	3/20
SCHEMBL16898040	0.88	3/20
SCHEMBL16898045	0.85	3/20
SCHEMBL16898047	0.85	3/20
SCHEMBL18241244	0.85	3/20
SCHEMBL18241246	0.85	3/20
SCHEMBL16898599	0.84	3/20

Clinical trials — most relevant to TLL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Gut-Liver Axis Modulation With IgG-Enriched Immunotherapy in Severe Alcohol-Associated Hepatitis	PHASE3	ACTIVE_NOT_RECRUITING
Thymosin Alpha 1 to Prevent COVID-19 Infection in Renal Dialysis Patients	PHASE2	COMPLETED
The Effects of GLA on Human Volunteers	PHASE1	COMPLETED
KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer	PHASE1	RECRUITING
TL1A Expression in Psoriatic Skin	nan	UNKNOWN
TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP)	nan	NOT_YET_RECRUITING
Obesity - Inflammation - Metabolic Disease: Effect of Lactobacillus Casei Shirota	nan	COMPLETED
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis	nan	COMPLETED
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers	nan	COMPLETED
Decoy Receptor 3 (DcR3) Polymorphisms in Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE)	nan	UNKNOWN
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population	nan	RECRUITING
Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions	nan	RECRUITING
Natural History of HPV From Infection to Neoplasia in Adolescents and Young Women	nan	COMPLETED
MicroRNAs and Cytokines in Peri-Implantitis Tissue	nan	UNKNOWN
Effect of Alcohol Consumption on Markers of Inflammation	nan	COMPLETED
Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants	nan	RECRUITING
Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis	nan	UNKNOWN
Immune Cell Response to Stimuli	nan	RECRUITING
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION	nan	RECRUITING
Imaging Genetics of Laryngeal Dystonia	nan	RECRUITING
Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome	nan	UNKNOWN
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
High-fat Challenge Induced Trained Innate Immunity (SHAKE Study)	nan	COMPLETED
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)	nan	RECRUITING
DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma	nan	COMPLETED
Cytokines in Papillon-Lefèvre Syndrome	nan	COMPLETED
CTHRC1: A Biomarker for Evaluation of Rheumatoid Arthritis Disease Activity	nan	UNKNOWN
Determining the Fingerprint of Endotoxin Tolerance	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TLL1 binder may also engage these)

Protein	Name	Similarity
O57382	—	1.000	O57382 →
Q62381	—	1.000	Q62381 →
O57460	—	1.000	O57460 →
Q8JI28	—	1.000	Q8JI28 →
P98063	—	0.999	P98063 →
TLL2	Tolloid-like protein 2	0.999	landscape →
Q20176	—	0.999	Q20176 →
Q9DER7	—	0.999	Q9DER7 →
Q9WVM6	—	0.999	Q9WVM6 →
P25723	—	0.997	P25723 →
BMP1	Bone morphogenetic protein 1	0.995	landscape →
Q5R1W3	—	0.993	Q5R1W3 →
P98070	—	0.991	P98070 →
Q69DK8	—	0.989	Q69DK8 →
Q8CFG9	—	0.988	Q8CFG9 →
Q9W332	—	0.988	Q9W332 →
P98060	—	0.988	P98060 →
Q4R577	—	0.988	Q4R577 →
TMPRSS15	Enteropeptidase	0.988	landscape →
P17945	—	0.987	P17945 →
P11214	—	0.987	P11214 →
Q9WTR0	—	0.986	Q9WTR0 →
MMP2	72 kDa type IV collagenase	0.986	landscape →
Q5R544	—	0.986	Q5R544 →
Q90WD8	—	0.986	Q90WD8 →
Q90611	—	0.986	Q90611 →
Q5G266	—	0.986	Q5G266 →
Q8CG16	—	0.985	Q8CG16 →
Q5R8X6	—	0.985	Q5R8X6 →
E1C3U7	—	0.985	E1C3U7 →