Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TOP2A | P11388 | 8/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibafloxacin SCHEMBL10073765 | 1.00 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Ibafloxacin SCHEMBL29465687 | 1.00 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL8083425 | 0.89 | LMNA (0.70) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10841687 | 0.88 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL16518639 | 0.88 | KDM4E (0.61) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10784346 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10785119 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Water SCHEMBL10842574 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10782548 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Water SCHEMBL10788704 | 0.86 | LMNA (0.67) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2286 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624057-B2 | Bisphosphonate quinolone conjugates and uses thereof | BIOVINC, LLC (US) | 2026-05-12 | — | — | US | claimed |
| US-12350281-B2 | Long-acting injectable formulations and use thereof | DECHRA VETERINARY PRODUCTS, LLC (US) | 2025-07-08 | — | — | US | claimed |
| EP-4554627-A1 | INHALABLE FORMULATION FOR USE IN THE TREATMENT OF BACTERIAL LUNG INFECTIONS | Solmic Biotech GmbH (DE) | 2025-05-21 | — | — | EP | claimed |
| US-20250144088-A1 | INHALABLE FORMULATION FOR USE IN THE TREATMENT OF BACTERIAL LUNG INFECTIONS | Solmic Biotech GmbH (DE) | 2025-05-08 | — | — | US | claimed |
| WO-2025080590-A1 | CO-CRYSTALLIZATION OF ACTIVES WITH SACCHARIDE-BASED MOLECULAR FRAMEWORKS | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2025-04-17 | — | — | WO | claimed |
| US-20250115942-A1 | SCREENING METHOD FOR ANTI-PSEUDOMONAL AGENTS AND COMPOSITIONS AND METHODS FOR TREATING PSEUDOMONAS INFECTIONS | BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGES | 2025-04-10 | — | — | US | claimed |
| US-12226527-B2 | Gel formulations for local drug release | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2025-02-18 | — | — | US | claimed |
| US-12042500-B2 | Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics | HYDERABAD EYE RESEARCH FOUNDATION (IN) | 2024-07-23 | — | — | US | claimed |
| CN-118256233-A | Pure organic room-temperature phosphorescent material based on sarcin drugs and preparation method thereof | 山东大学 | 2024-06-28 | — | — | CN | claimed |
| US-20240182504-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BIOVINC LLC (US) | 2024-06-06 | — | — | US | claimed |
| US-20040077601-A1 | Methods and compositions relating to isoleucine boroproline compounds | POINT THERAPEUTICS, INC. | 2004-04-22 | — | — | US | claimed |
| WO-2004004658-A2 | METHODS AND COMPOSITIONS RELATING TO ISOLEUCINE BOROPROLINE COMPOUNDS | POINT THERAPEUTICS, INC. (US) | 2004-01-15 | — | — | WO | claimed |
| EP-0443381-B2 | Effervescent composition, its production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| US-5223246-A | Powdered mixture of antibacterial oxo-carboxylic acids having fused nitrogen rings, carbonates, water soluble binders, for treatment of drinking water for livestock | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | claimed |
| EP-0245913-B1 | Process for preparing 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | RIKER LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0443381-A1 | Effervescent composition, its production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | claimed |
| US-4898945-A | Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-02-06 | — | — | US | claimed |
| EP-0109284-B1 | 6,7-DIHYDRO-5,8-DIMETHYL-9-FLUORO-1-OXO-1H,5H-BENZO(IJ)QUINOLIZINE-2-CARBOXYLIC ACID AND DERIVATIVES | RIKER LABORATORIES, INC. (US) | 1989-01-11 | — | — | EP | claimed |
| EP-0245913-A1 | Process for preparing 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | RIKER LABORATORIES, INC. (US) | 1987-11-19 | — | — | EP | claimed |
| EP-0109284-A1 | 6,7-Dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid and derivatives | RIKER LABORATORIES, INC. (US) | 1984-05-23 | — | — | EP | claimed |