KLK13 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22807612	0.57	1/20
SCHEMBL23104993	0.56	1/20
SCHEMBL23104952	0.55	1/20
SCHEMBL21959068	0.54	1/20
SCHEMBL27286988	0.53	1/20
SCHEMBL25820488	0.52	1/20
SCHEMBL25822040	0.52	1/20
SCHEMBL25822092	0.52	1/20
SCHEMBL25822194	0.52	1/20
SCHEMBL25455267	0.52	1/20
SCHEMBL25455920	0.52	1/20
SCHEMBL27288480	0.52	1/20
SCHEMBL23104948	0.51	1/20
SCHEMBL25458754	0.51	1/20
SCHEMBL25459306	0.50	1/20
SCHEMBL21553589	0.50	1/20
SCHEMBL25455662	0.49	1/20
SCHEMBL24218646	0.49	1/20
Protegrin 1 (SCHEMBL29352276)	0.49	1/20
SCHEMBL29388123	0.49	1/20

Clinical trials — most relevant to KLK13 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy(LSG)	PHASE4	COMPLETED
Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II	PHASE3	COMPLETED
CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema	PHASE3	COMPLETED
Safety and Efficacy of AGN-INM176 in Prostate Patients With Rising PSA	PHASE1/PHASE2	RECRUITING
Lycopene in Treating Patients Undergoing Radical Prostatectomy for Prostate Cancer	PHASE2	COMPLETED
Selenomethionine and Finasteride Before Surgery or Radiation Therapy in Treating Patients With Stage I or Stage II Prostate Cancer	PHASE2	COMPLETED
Immunotherapy With N 803, ETBX-071, and M-CENK in Combination With Radiation for Participants With High-Risk Prostate Cancer.	PHASE2	WITHDRAWN
Combining Ipilimumab With Abiraterone Acetate Plus Prednisone in Chemotherapy and Immunotherapy-naïve Patients With Progressive Metastatic Castration-resistant Prostate Cancer	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Food Effect Study of Abiraterone Acetate for Treatment of Patients With Castration-Resistant Prostate Cancer	PHASE2	COMPLETED
Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke	PHASE2	COMPLETED
PROSTVAC (PSA-TRICOM) in Preventing Disease Progression in Patients With Localized Prostate Cancer Undergoing Active Surveillance	PHASE2	COMPLETED
A Positron Emission Tomography/Computed Tomography (PET/CT) Bone Imaging Study in Patients Receiving Enzalutamide for Castration-Resistant Prostate Cancer (CRPC)	PHASE2	COMPLETED
177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Cabozantinib (XL-184) Monotherapy for Advanced Cholangiocarcinoma	PHASE2	COMPLETED
ESK981 in Treating Patients With Metastatic Castrate-Resistant Prostate Cancer	PHASE2	COMPLETED
Dose-Seeking Trial of PCK3145 in Asymptomatic, Castrate Metastatic Prostate Cancer Patients.	PHASE1	COMPLETED
Vaccination of Prostate Cancer Patients With MUC-2-KLH Conjugate Plus the Immunological Adjuvant QS21	PHASE1	COMPLETED
Study to Assess PK, Safety and Tolerability in Healthy Subjects	PHASE1	COMPLETED
Phase Ib Feasibility Trial of Neoadjuvant Nivolumab/Lirilumab in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer	PHASE1	COMPLETED
Study Investigating Intravesical HDAC Inhibition to Improve Response to Immuno-Oncology Agents	PHASE1	SUSPENDED
Kisspeptin Administration in the Adult	PHASE1	COMPLETED
Phase I Open Label Dose Escalation Study to Investigate the Safety & Pharmacokinetics of AZD5312 in Patients With Androgen Receptor Tumors	PHASE1	COMPLETED
The Investigation of New Biological Markers for Prostate Cancer Diagnosis and Management in Chinese Population	nan	RECRUITING
A Randomized Trial of Early Detection of Clinically Significant Prostate Cancer (ProScreen)	nan	ENROLLING_BY_INVITATION
Magnetic Resonance Imaging to Locate and Characterize Prostate Cancer	nan	COMPLETED
Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis	nan	RECRUITING
Predicting Prostate Biopsy Results With Biomarkers and mpMRI.	nan	COMPLETED
Urinary Kallikrein and Hypertension: A Prospective Study	nan	COMPLETED
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)	nan	RECRUITING
DKK3 for Prognosis and Monitoring of GFR Decline in Heart Failure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KLK13 binder may also engage these)

Protein	Name	Similarity
KLK3	Prostate-specific antigen	0.995	landscape →
P33619	—	0.990	P33619 →
KLK2	Kallikrein-2	0.990	landscape →
P50342	—	0.989	P50342 →
TPSAB1	Tryptase beta-1	0.989	landscape →
P09582	—	0.989	P09582 →
TPSB2	Tryptase beta-2	0.987	landscape →
P21845	—	0.987	P21845 →
Q6DT45	—	0.987	Q6DT45 →
Q9XSM2	—	0.985	Q9XSM2 →
Q9N2D1	—	0.985	Q9N2D1 →
P09650	—	0.984	P09650 →
P83748	—	0.984	P83748 →
Q76B45	—	0.983	Q76B45 →
Q8BJR6	—	0.983	Q8BJR6 →
Q07276	—	0.983	Q07276 →
Q9ESD1	—	0.983	Q9ESD1 →
KLK6	Kallikrein-6	0.983	landscape →
P56435	—	0.983	P56435 →
P27435	—	0.982	P27435 →
Q9QYZ9	—	0.982	Q9QYZ9 →
A7WPL7	—	0.982	A7WPL7 →
Q28773	—	0.981	Q28773 →
P50341	—	0.981	P50341 →
P50343	—	0.981	P50343 →
Q99MS4	—	0.981	Q99MS4 →
P15944	—	0.980	P15944 →
Q9JHJ7	—	0.980	Q9JHJ7 →
KLK7	Kallikrein-7	0.980	landscape →
Q920S2	—	0.980	Q920S2 →