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Sugi Predict / Targets / TSSK1B

TSSK1B

Testis-specific serine/threonine-protein kinase 1 · Q9BXA7 · TSSK1B on Sugi Atlas →

4,293 patent compounds predicted against TSSK1B, 3,461 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3666733 SCHEMBL3666733 1.00 3/20
SCHEMBL3666862 SCHEMBL3666862 0.82 3/20
SCHEMBL3667440 SCHEMBL3667440 0.82 3/20
SCHEMBL3666765 SCHEMBL3666765 0.81 3/20
SCHEMBL3669428 SCHEMBL3669428 0.79 3/20
SCHEMBL3668495 SCHEMBL3668495 0.79 3/20
SCHEMBL3668307 SCHEMBL3668307 0.78 3/20
SCHEMBL3671042 SCHEMBL3671042 0.75 3/20
SCHEMBL3671629 SCHEMBL3671629 0.74 3/20
SCHEMBL3668102 SCHEMBL3668102 0.72 3/20
SCHEMBL3668873 SCHEMBL3668873 0.72 3/20
SCHEMBL3668957 SCHEMBL3668957 0.72 3/20
SCHEMBL3672598 SCHEMBL3672598 0.71 3/20
SCHEMBL3673057 SCHEMBL3673057 0.71 3/20
SCHEMBL3668190 SCHEMBL3668190 0.69 3/20
SCHEMBL3670939 SCHEMBL3670939 0.69 3/20
SCHEMBL146734 SCHEMBL146734 0.67 3/20
SCHEMBL144651 SCHEMBL144651 0.67 3/20
SCHEMBL146677 SCHEMBL146677 0.67 3/20
SCHEMBL3668169 SCHEMBL3668169 0.67 3/20

Clinical trials — most relevant to TSSK1B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men PHASE3ACTIVE_NOT_RECRUITING
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Randomized Controlled Study of Postoperative Adjuvant Therapy for Gastric Cancer Using TS-1 or TS-1+PSK PHASE3COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety PHASE2COMPLETED
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer PHASE1/PHASE2WITHDRAWN
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Sorafenib Tosylate and Gene Expression Analysis in Patients Undergoing Surgery For High-Risk Localized Prostate Cancer PHASE2COMPLETED
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease nanRECRUITING
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
Identification of Novel Targetable Kinases in SR-a GvHD nanCOMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
Cause of Familial Testicular Cancer nanCOMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Study of Sperm Molecular Factors Implicated in Male Fertility nanCOMPLETED
A Retro-/Prospective, Non-interventional, Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion, Treated With Larotrectinib nanCOMPLETED
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development nanCOMPLETED
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer nanUNKNOWN
New Genes in the Carcinogenesis of Colorectal Cancer nanUNKNOWN
WEST-KOaST Study: WES Analysis of Testicular Cancer Patientsand Their First-degree Family Members nanNOT_YET_RECRUITING
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children nanCOMPLETED
Azoospermia Patients nanRECRUITING
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm nanCOMPLETED
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TSSK1B binder may also engage these)

ProteinNameSimilarity
Q3SZW1 — 0.996 Q3SZW1 →
TSSK2 Testis-specific serine/threonine-protein kinase 2 0.994 landscape →
Q61241 — 0.993 Q61241 →
O54863 — 0.993 O54863 →
Q8BG48 — 0.983 Q8BG48 →
Q6SA08 — 0.981 Q6SA08 →
Q91XS8 — 0.980 Q91XS8 →
Q9Z265 — 0.980 Q9Z265 →
P62205 — 0.979 P62205 →
Q9GM70 — 0.979 Q9GM70 →
Q8C1R0 — 0.978 Q8C1R0 →
MELK Maternal embryonic leucine zipper kinase 0.978 landscape →
Q9WVS4 — 0.978 Q9WVS4 →
Q9YHZ5 — 0.978 Q9YHZ5 →
PLK2 Serine/threonine-protein kinase PLK2 0.978 landscape →
MOK MAPK/MAK/MRK overlapping kinase 0.978 landscape →
Q61846 — 0.977 Q61846 →
Q5R4L1 — 0.977 Q5R4L1 →
Q38997 — 0.977 Q38997 →
Q0JI49 — 0.976 Q0JI49 →
Q91821 — 0.976 Q91821 →
STK17B Serine/threonine-protein kinase 17B 0.976 landscape →
STK17A Serine/threonine-protein kinase 17A 0.975 landscape →
Q9JJX8 — 0.975 Q9JJX8 →
Q6H7U5 — 0.975 Q6H7U5 →
Q95LJ0 — 0.974 Q95LJ0 →
Q9D411 — 0.974 Q9D411 →
Q9R012 — 0.974 Q9R012 →
O54785 — 0.974 O54785 →
PDPK1 3-phosphoinositide-dependent protein kinase 1 0.974 landscape →