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TSSK3

Testis-specific serine/threonine-protein kinase 3 · Q96PN8 · TSSK3 on Sugi Atlas →

138 patent compounds predicted against TSSK3, 107 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL18624758 SCHEMBL18624758 0.68 2/20
SCHEMBL14795782 SCHEMBL14795782 0.51 2/20
SCHEMBL25878688 SCHEMBL25878688 0.46 2/20
SCHEMBL29484631 SCHEMBL29484631 0.46 2/20
SCHEMBL14917492 SCHEMBL14917492 0.42 2/20
SCHEMBL14917494 SCHEMBL14917494 0.42 2/20
SCHEMBL29466287 SCHEMBL29466287 0.36 2/20
SCHEMBL1613241 SCHEMBL1613241 1.00 1/20
SCHEMBL12714976 SCHEMBL12714976 0.81 1/20
SCHEMBL12742679 SCHEMBL12742679 0.72 1/20
SCHEMBL18603928 SCHEMBL18603928 0.70 1/20
SCHEMBL18643038 SCHEMBL18643038 0.70 1/20
SCHEMBL12714969 SCHEMBL12714969 0.70 1/20
SCHEMBL12714967 SCHEMBL12714967 0.69 1/20
SCHEMBL12714288 SCHEMBL12714288 0.63 1/20
SCHEMBL18603768 SCHEMBL18603768 0.63 1/20
SCHEMBL15643447 SCHEMBL15643447 0.61 1/20
SCHEMBL12743822 SCHEMBL12743822 0.60 1/20
SCHEMBL17085573 SCHEMBL17085573 0.60 1/20
SCHEMBL18624756 SCHEMBL18624756 0.60 1/20

Clinical trials — most relevant to TSSK3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men PHASE3ACTIVE_NOT_RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
PROS-1-Male Hormonal Contraceptive Regimens on Prostate Tissue PHASE2/PHASE3COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Selenomethionine and Finasteride Before Surgery or Radiation Therapy in Treating Patients With Stage I or Stage II Prostate Cancer PHASE2COMPLETED
Sorafenib Tosylate and Gene Expression Analysis in Patients Undergoing Surgery For High-Risk Localized Prostate Cancer PHASE2COMPLETED
Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer PHASE1/PHASE2WITHDRAWN
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Enzalutamide and Cabazitaxel in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 EARLY_PHASE1COMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer nanUNKNOWN
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease nanRECRUITING
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
Cause of Familial Testicular Cancer nanCOMPLETED
Study of Sperm Molecular Factors Implicated in Male Fertility nanCOMPLETED
Warfarin Effects on Male Fertility After Cardiac Surgery nanNOT_YET_RECRUITING
WEST-KOaST Study: WES Analysis of Testicular Cancer Patientsand Their First-degree Family Members nanNOT_YET_RECRUITING
Azoospermia Patients nanRECRUITING
Surgical Sperm Retrieval in Non-obstructive Azoospermic Men: mTESE vs. TESA nanCOMPLETED
Identification of Novel Targetable Kinases in SR-a GvHD nanCOMPLETED
A Retro-/Prospective, Non-interventional, Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion, Treated With Larotrectinib nanCOMPLETED
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development nanCOMPLETED
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm nanCOMPLETED
Turner Syndrome: Genetic Considerations nanRECRUITING
Testicular Function After Testicular Torsion nanUNKNOWN
Targeted Radiotherapy for Recurrent Prostate Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TSSK3 binder may also engage these)

ProteinNameSimilarity
Q9D2E1 — 1.000 Q9D2E1 →
TSSK6 Testis-specific serine/threonine-protein kinase 6 0.988 landscape →
Q925K9 — 0.987 Q925K9 →
Q9M077 — 0.970 Q9M077 →
Q9W739 — 0.969 Q9W739 →
Q683C9 — 0.969 Q683C9 →
Q2PQN9 — 0.969 Q2PQN9 →
Q9QYK9 — 0.968 Q9QYK9 →
Q6SA08 — 0.968 Q6SA08 →
Q38774 — 0.968 Q38774 →
Q80YP0 — 0.968 Q80YP0 →
P51166 — 0.967 P51166 →
O70150 — 0.966 O70150 →
P29619 — 0.966 P29619 →
Q03114 — 0.966 Q03114 →
SGK2 Serine/threonine-protein kinase Sgk2 0.966 landscape →
P25859 — 0.966 P25859 →
O88445 — 0.965 O88445 →
Q5RCH1 — 0.965 Q5RCH1 →
Q26671 — 0.965 Q26671 →
P48609 — 0.965 P48609 →
Q8R4U9 — 0.964 Q8R4U9 →
PNCK Calcium/calmodulin-dependent protein kinase type 1B 0.964 landscape →
Q54SJ5 — 0.964 Q54SJ5 →
Q5JLD8 — 0.963 Q5JLD8 →
Q9WUI1 — 0.963 Q9WUI1 →
Q9QZS5 — 0.963 Q9QZS5 →
RPS6KA1 Ribosomal protein S6 kinase alpha-1 0.963 landscape →
Q05006 — 0.963 Q05006 →
P34112 — 0.963 P34112 →