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U2SURP

U2 snRNP-associated SURP motif-containing protein · O15042 · U2SURP on Sugi Atlas →

2,210 patent compounds predicted against U2SURP, 1,963 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4699731 SCHEMBL4699731 1.00 2/20
SCHEMBL4697866 SCHEMBL4697866 0.89 2/20
SCHEMBL4697696 SCHEMBL4697696 0.86 2/20
SCHEMBL4699947 SCHEMBL4699947 0.83 2/20
SCHEMBL4699140 SCHEMBL4699140 0.80 2/20
SCHEMBL4922941 SCHEMBL4922941 0.80 2/20
SCHEMBL4916509 SCHEMBL4916509 0.78 2/20
SCHEMBL4700123 SCHEMBL4700123 0.77 2/20
SCHEMBL4698636 SCHEMBL4698636 0.76 2/20
SCHEMBL4917606 SCHEMBL4917606 0.76 2/20
SCHEMBL4908396 SCHEMBL4908396 0.74 2/20
SCHEMBL4699183 SCHEMBL4699183 0.74 2/20
SCHEMBL4914310 SCHEMBL4914310 0.73 2/20
SCHEMBL4915098 SCHEMBL4915098 0.73 2/20
SCHEMBL4696222 SCHEMBL4696222 0.72 2/20
SCHEMBL4701699 SCHEMBL4701699 0.70 2/20
SCHEMBL4698169 SCHEMBL4698169 0.70 2/20
SCHEMBL4696537 SCHEMBL4696537 0.68 2/20
SCHEMBL4920392 SCHEMBL4920392 0.66 2/20
SCHEMBL14070246 SCHEMBL14070246 0.63 2/20

Clinical trials — most relevant to U2SURP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Valproate and Levocarnitine in Children With Spinal Muscular Atrophy PHASE3UNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
NFC Changes in SLE Patients and Its Correlation With Anti-U1RNPAntibodies and Disease Activity nanUNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
Patient's Derived Organoids for Drug Screening in Glioblastoma nanNOT_YET_RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Biocollection in MyeloDysplastic Syndrome (P-MDS) nanRECRUITING
Home Monitoring of Adult Patients With SMA: a Pilot Multicenter Validation Study nanUNKNOWN
Mechanisms of Cell Death in Spinal Muscular Atrophy nanCOMPLETED
SMN Circular RNAs as Potential Biomarkers for the Therapeutic Response to Nusinersen in Spinal Muscular Atrophy Patients nanUNKNOWN
Molecular Disease Profile of Hematological Malignancies nanUNKNOWN
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF) nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs nanUNKNOWN
Outcome Measures and Biomarkers in a Cohort of Spinal Muscular Atrophy Type III/ IV Patients nanACTIVE_NOT_RECRUITING
Research for Individualized Therapeutics in Rare Genetic Disease nanENROLLING_BY_INVITATION
Timisnar - Biomarkers Substudy (Timisnar-mirna) nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN
Diagnosis of Inflammatory Bowel Disease nanNOT_YET_RECRUITING
New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy nanCOMPLETED
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis nanCOMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes nanUNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
SMN Circular RNAs as Potential New Targets and Biomarkers for SMA nanUNKNOWN
SRSF2 Gene Mutation in Patients With t-MDS/AML nanCOMPLETED
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a U2SURP binder may also engage these)

ProteinNameSimilarity
Q6NV83 — 1.000 Q6NV83 →
Q5R7X2 — 1.000 Q5R7X2 →
B2RY56 — 0.996 B2RY56 →
A0A286Y9D1 — 0.992 A0A286Y9D1 →
O59800 — 0.991 O59800 →
Q6GLQ4 — 0.991 Q6GLQ4 →
Q95XU6 — 0.991 Q95XU6 →
Q641G3 — 0.990 Q641G3 →
B4LIK8 — 0.990 B4LIK8 →
B3MJ69 — 0.989 B3MJ69 →
SMARCC2 SWI/SNF complex subunit SMARCC2 0.989 landscape →
Q8BMD7 — 0.989 Q8BMD7 →
A1XD93 — 0.988 A1XD93 →
O75061 — 0.988 O75061 →
B4II37 — 0.988 B4II37 →
Q9VJY8 — 0.988 Q9VJY8 →
P92204 — 0.988 P92204 →
Q56P03 — 0.988 Q56P03 →
P35611 — 0.988 P35611 →
Q9W261 — 0.988 Q9W261 →
G5EEM9 — 0.988 G5EEM9 →
Q7YQL3 — 0.987 Q7YQL3 →
Q5R6D8 — 0.987 Q5R6D8 →
P42698 — 0.987 P42698 →
Q4G055 — 0.987 Q4G055 →
B4H732 — 0.987 B4H732 →
Q5RAK6 — 0.987 Q5RAK6 →
Q8BHR2 — 0.987 Q8BHR2 →
Q3ZC12 — 0.987 Q3ZC12 →
EIF3G Eukaryotic translation initiation factor 3 subunit G 0.987 landscape →