Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 4/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.69 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.69 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.69 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.69 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12298368 | 0.88 | ALOX5 (0.75) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL7109033 | 0.86 | VCP (0.76) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL207572 | 0.86 | VCP (0.76) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL7111888 | 0.86 | VCP (0.76) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL1892520 | 0.86 | VCP (0.76) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL1821422 | 0.86 | VCP (0.76) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL208320 | 0.86 | VCP (0.71) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL6155931 | 0.86 | VCP (0.67) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL207590 | 0.85 | ALOX5 (0.68) | VCPALOX5MAPTMEN1KMT2A | |
| SCHEMBL1821487 | 0.83 | VCP (0.71) | VCPALOX5MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | PIGS, CPT1A, SLC10A1 | VCP 1270/4885ALOX5 3410/4885MAPT 2207/4885 |
| US-20070004711-A1 | Thiazole compounds and methods of use | PIGS, CPT1A, SLC10A1 | VCP 1270/4885ALOX5 3410/4885MAPT 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.