YWHAZ

14-3-3 protein zeta/delta · P63104 · YWHAZ on Sugi Atlas →

498 patent compounds predicted against YWHAZ, 236 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL26442038 SCHEMBL26442038 0.50 8/20
SCHEMBL18025617 SCHEMBL18025617 0.46 7/20
SCHEMBL14749717 SCHEMBL14749717 0.74 5/20
SCHEMBL13770408 SCHEMBL13770408 0.73 5/20
SCHEMBL14749613 SCHEMBL14749613 0.73 5/20
SCHEMBL14749819 SCHEMBL14749819 0.65 5/20
SCHEMBL14749539 SCHEMBL14749539 0.65 5/20
SCHEMBL29380328 SCHEMBL29380328 0.65 5/20
SCHEMBL14749604 SCHEMBL14749604 0.57 5/20
SCHEMBL29608463 SCHEMBL29608463 0.57 5/20
SCHEMBL14749627 SCHEMBL14749627 0.54 5/20
SCHEMBL15828667 SCHEMBL15828667 0.43 5/20
SCHEMBL30927126 SCHEMBL30927126 1.00 4/20
SCHEMBL14749541 SCHEMBL14749541 0.90 4/20
SCHEMBL13764968 SCHEMBL13764968 0.81 4/20
SCHEMBL13770406 SCHEMBL13770406 0.67 4/20
SCHEMBL30811936 SCHEMBL30811936 0.62 4/20
SCHEMBL25831036 SCHEMBL25831036 0.53 4/20
SCHEMBL25831123 SCHEMBL25831123 0.53 4/20
SCHEMBL30927128 SCHEMBL30927128 0.52 4/20

Clinical trials — most relevant to YWHAZ by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients PHASE3COMPLETED
NG2 and DLL3 CAR-T Cells Targeting Melanoma PHASE1/PHASE2RECRUITING
Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma PHASE2COMPLETED
Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia PHASE1/PHASE2COMPLETED
Dasatinib in Treating Patients With Chronic Lymphocytic Leukemia PHASE2COMPLETED
Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Nonmalignant Hematologic Disease PHASE2COMPLETED
Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer PHASE2COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment PHASE2COMPLETED
Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome PHASE2COMPLETED
A Phase II Evaluation of Dasatinib (Sprycel®, NSC #732517) in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma PHASE2COMPLETED
GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma PHASE2ACTIVE_NOT_RECRUITING
CLL-Irl Study. CTRIAL-IE (ICORG) 07-01, V7 PHASE2COMPLETED
90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Auranofin in Treating Patients With Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer EARLY_PHASE1COMPLETED
Relationship of YWHAH Polymorphisms to Rheumatoid Arthritis Disease Severity nanCOMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome nanACTIVE_NOT_RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis nanCOMPLETED
Semen Analysis Changes in Covid-19 Positivepatients nanCOMPLETED
X-chromosome Inactivation, Epigenetics and the Transcriptome nanCOMPLETED
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma nanCOMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
The Clinical Study of Sex Chromosome Variants nanCOMPLETED
Chromosome 9 P Minus Syndrome nanRECRUITING
Phenotypic Properties in Individuals Affected With XLHED nanCOMPLETED
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle? nanUNKNOWN
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs) nanRECRUITING
Blood-based Biomarkers for the Prognosis of Sports Related Concussion nanCOMPLETED
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure nanRECRUITING
Unusual Infiltrative Patterns of Malignant Cells in Endometrial Carcinoma and Immunohistochemical Expression of P53 nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a YWHAZ binder may also engage these)

ProteinNameSimilarity
Q5R651 1.000 Q5R651 →
Q5ZKC9 1.000 Q5ZKC9 →
P63102 1.000 P63102 →
P63103 1.000 P63103 →
Q91896 1.000 Q91896 →
P29361 1.000 P29361 →
P63101 1.000 P63101 →
Q6UFZ8 1.000 Q6UFZ8 →
P68250 1.000 P68250 →
Q9C5W6 1.000 Q9C5W6 →
Q1HR36 1.000 Q1HR36 →
Q6UFZ9 1.000 Q6UFZ9 →
P48347 1.000 P48347 →
Q7T356 1.000 Q7T356 →
YWHAG 14-3-3 protein gamma 1.000 landscape →
Q5RC20 1.000 Q5RC20 →
P68255 1.000 P68255 →
Q5PRD0 1.000 Q5PRD0 →
Q52M98 1.000 Q52M98 →
A4K2U9 1.000 A4K2U9 →
Q4R572 1.000 Q4R572 →
YWHAB 14-3-3 protein beta/alpha 1.000 landscape →
YWHAQ 14-3-3 protein theta 1.000 landscape →
Q6PCG0 1.000 Q6PCG0 →
Q5ZLQ6 1.000 Q5ZLQ6 →
Q9CQV8 1.000 Q9CQV8 →
P41932 1.000 P41932 →
P48348 1.000 P48348 →
P35213 1.000 P35213 →
P48349 1.000 P48349 →