YWHAZ
14-3-3 protein zeta/delta
498 patent compounds predicted against YWHAZ, 236 high-confidence (nearest known ligand ≥ 0.5)
Top predicted compounds (top 20 by supporting neighbours, then confidence)
| Compound | Confidence | Supporting neighbours | |
|---|---|---|---|
| SCHEMBL26442038 | 0.50 | 8/20 | |
| SCHEMBL18025617 | 0.46 | 7/20 | |
| SCHEMBL14749717 | 0.74 | 5/20 | |
| SCHEMBL13770408 | 0.73 | 5/20 | |
| SCHEMBL14749613 | 0.73 | 5/20 | |
| SCHEMBL14749819 | 0.65 | 5/20 | |
| SCHEMBL14749539 | 0.65 | 5/20 | |
| SCHEMBL29380328 | 0.65 | 5/20 | |
| SCHEMBL14749604 | 0.57 | 5/20 | |
| SCHEMBL29608463 | 0.57 | 5/20 | |
| SCHEMBL14749627 | 0.54 | 5/20 | |
| SCHEMBL15828667 | 0.43 | 5/20 | |
| SCHEMBL30927126 | 1.00 | 4/20 | |
| SCHEMBL14749541 | 0.90 | 4/20 | |
| SCHEMBL13764968 | 0.81 | 4/20 | |
| SCHEMBL13770406 | 0.67 | 4/20 | |
| SCHEMBL30811936 | 0.62 | 4/20 | |
| SCHEMBL25831036 | 0.53 | 4/20 | |
| SCHEMBL25831123 | 0.53 | 4/20 | |
| SCHEMBL30927128 | 0.52 | 4/20 |
Germline variants in YWHAZ on Sugi Variant →
ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL)
Full YWHAZ gene report on Sugi Atlas →
Gene function, pathways, protein structure, constraint & interactions
Clinical trials — most relevant to YWHAZ by text similarity (a relevance ranking, not an exhaustive list)
Related proteins — ESM-2 sequence neighbours (a YWHAZ binder may also engage these)
| Protein | Name | Similarity | |
|---|---|---|---|
| Q5R651 | — | 1.000 | Q5R651 → |
| Q5ZKC9 | — | 1.000 | Q5ZKC9 → |
| P63102 | — | 1.000 | P63102 → |
| P63103 | — | 1.000 | P63103 → |
| Q91896 | — | 1.000 | Q91896 → |
| P29361 | — | 1.000 | P29361 → |
| P63101 | — | 1.000 | P63101 → |
| Q6UFZ8 | — | 1.000 | Q6UFZ8 → |
| P68250 | — | 1.000 | P68250 → |
| Q9C5W6 | — | 1.000 | Q9C5W6 → |
| Q1HR36 | — | 1.000 | Q1HR36 → |
| Q6UFZ9 | — | 1.000 | Q6UFZ9 → |
| P48347 | — | 1.000 | P48347 → |
| YWHAG | 14-3-3 protein gamma | 1.000 | landscape → |
| Q5RC20 | — | 1.000 | Q5RC20 → |
| Q7T356 | — | 1.000 | Q7T356 → |
| P68255 | — | 1.000 | P68255 → |
| Q52M98 | — | 1.000 | Q52M98 → |
| Q5PRD0 | — | 1.000 | Q5PRD0 → |
| Q4R572 | — | 1.000 | Q4R572 → |
| YWHAB | 14-3-3 protein beta/alpha | 1.000 | landscape → |
| A4K2U9 | — | 1.000 | A4K2U9 → |
| YWHAQ | 14-3-3 protein theta | 1.000 | landscape → |
| Q6PCG0 | — | 1.000 | Q6PCG0 → |
| Q5ZLQ6 | — | 1.000 | Q5ZLQ6 → |
| Q9CQV8 | — | 1.000 | Q9CQV8 → |
| P41932 | — | 1.000 | P41932 → |
| P48348 | — | 1.000 | P48348 → |
| P35213 | — | 1.000 | P35213 → |
| P48349 | — | 1.000 | P48349 → |