Is DCST1 p.Arg225His (c.674G>A) pathogenic?

DCST1 p.Arg225His (c.674G>A) is classified Likely benign in DCST1 (ClinVar, Single submitter, 1 submitter; last evaluated 2023-05-15). AlphaMissense: likely benign (0.0802); Ultra-rare (popmax 0.0329%, mid).

How common is DCST1 p.Arg225His (c.674G>A) in the general population?

DCST1 p.Arg225His (c.674G>A) is ultra-rare (popmax 0.0329%, mid) (gnomAD).

What do computational predictors say about DCST1 p.Arg225His (c.674G>A)?

AlphaMissense predicts likely benign (score 0.0802) — an in-silico prediction, not a clinical call.

DCST1 p.Arg225His

c.674G>A · rs779688952 · VCV2516673

Likely benign Single submitter

Classification

Likely benign

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0802 · ACMG-weighted

gnomAD v4.1

Rare

ultra-rare (popmax 0.0329%, mid)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0802	likely benign
REVEL	0.021	moderately benign-leaning
SaProt	LLR -9.46	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -8.1	GERP -3.1
Regional constraint	o/e 0.97	unconstrained · MANE · 17 kb · p 0.35 · regional, not allelic
Overall
CADD	0.012	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0329% Middle Eastern · 2/6,084 alleles

Filtering AF 0.00751% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00593%

Overall 0.00359% 58/1,613,872 alleles · ultra-rare

Ancestry group	Frequency	1 in
Middle Easterngrpmax	0.0329%	3,042
South Asian	0.0132%	7,590
Remaining individualsnot grpmax-eligible	0.0048%	20,827
East Asian	0.00446%	22,444
African / African-American	0.004%	24,973
European (non-Finnish)	0.00305%	32,779

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: DCST1
Protein: p.Arg225His
Coding: c.674G>A
MANE Select: NM_152494
dbSNP: rs779688952
Type: single nucleotide variant
Location: chr1:155041539 (GRCh38)
Gene constraint: LOEUF 1.032 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 80.35
Residue 225: the 'disordered' region

Full DCST1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

DCST1 p.Arg225Cys Uncertain significance ★ ⚠ same residue
DCST1 p.Ala199Val Benign ★★ same type
DCST1 p.Thr158Ile Benign ★★ ⚠ same type
DCST1 p.Tyr362= Benign/Likely benign ★★ same type
DCST1 p.Ala103Thr Uncertain significance ★ ⚠ same type
DCST1 p.Ala124Pro Uncertain significance ★ ⚠ same type
DCST1 p.Ala124Thr Uncertain significance ★ ⚠ same type
DCST1 p.Ala219Val Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/dcst1-p-arg225his (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown