DCST1 — 129 ClinVar variants
All ClinVar germline DCST1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 122 flagged for review →
2 Benign · 1 Benign/Likely benign · 9 Likely benign · 117 Uncertain significance
Full DCST1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 122
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCST1 p.Ala103Thr Uncertain significance Single submitter
- DCST1 p.Ala124Pro Uncertain significance Single submitter
- DCST1 p.Ala124Thr Uncertain significance Single submitter
- DCST1 p.Ala219Val Uncertain significance Single submitter
- DCST1 p.Ala391Ser Uncertain significance Single submitter
- DCST1 p.Ala450Ser Uncertain significance Single submitter
- DCST1 p.Ala612Thr Uncertain significance Single submitter
- DCST1 p.Arg117Ser Uncertain significance Single submitter
- DCST1 p.Arg14Lys Uncertain significance Single submitter
- DCST1 p.Arg15Gly Uncertain significance Single submitter
- DCST1 p.Arg163Pro Uncertain significance Single submitter
- DCST1 p.Arg170Gln Uncertain significance Single submitter
- DCST1 p.Arg260His Uncertain significance Single submitter
- DCST1 p.Arg404His Uncertain significance Single submitter
- DCST1 p.Arg433His Uncertain significance Single submitter
- DCST1 p.Arg616Gln Uncertain significance Single submitter
- DCST1 p.Asn142Lys Uncertain significance Single submitter
- DCST1 p.Asn407Ile Uncertain significance Single submitter
- DCST1 p.Asn70Lys Uncertain significance Single submitter
- DCST1 p.Asp175Glu Uncertain significance Single submitter
- DCST1 p.Asp211Gly Uncertain significance Single submitter
- DCST1 p.Asp418Asn Uncertain significance Single submitter
- DCST1 p.Asp477Glu Uncertain significance Single submitter
- DCST1 p.Asp485His Uncertain significance Single submitter
- DCST1 p.Cys646Tyr Uncertain significance Single submitter
- DCST1 p.Cys665Tyr Uncertain significance Single submitter
- DCST1 p.Cys670Tyr Uncertain significance Single submitter
- DCST1 p.Gln13Glu Uncertain significance Single submitter
- DCST1 p.Gln322His Uncertain significance Single submitter
- DCST1 p.Gln41His Uncertain significance Single submitter
- DCST1 p.Gln619Arg Uncertain significance Single submitter
- DCST1 p.Gln7Pro Uncertain significance Single submitter
- DCST1 p.Glu76Lys Uncertain significance Single submitter
- DCST1 p.Gly122Arg Uncertain significance Single submitter
- DCST1 p.Gly148Asp Uncertain significance Single submitter
- DCST1 p.Gly344Glu Uncertain significance Single submitter
- DCST1 p.Gly375Arg Uncertain significance Single submitter
- DCST1 p.Gly58Val Uncertain significance Single submitter
- DCST1 p.Gly634Ser Uncertain significance Single submitter
- DCST1 p.His138Gln Uncertain significance Single submitter
- DCST1 p.His501Asn Uncertain significance Single submitter
- DCST1 p.Ile164Ser Uncertain significance Single submitter
- DCST1 p.Ile190Met Uncertain significance Single submitter
- DCST1 p.Ile256Met Uncertain significance Single submitter
- DCST1 p.Ile441Thr Uncertain significance Single submitter
- DCST1 p.Ile487Val Uncertain significance Single submitter
- DCST1 p.Ile62Leu Uncertain significance Single submitter
- DCST1 p.Ile62Met Uncertain significance Single submitter
- DCST1 p.Leu183Pro Uncertain significance Single submitter
- DCST1 p.Leu30Val Uncertain significance Single submitter
- DCST1 p.Leu470Val Uncertain significance Single submitter
- DCST1 p.Leu598Val Uncertain significance Single submitter
- DCST1 p.Lys588Asn Uncertain significance Single submitter
- DCST1 p.Met239Leu Uncertain significance Single submitter
- DCST1 p.Met271Val Uncertain significance Single submitter
- DCST1 p.Met512Ile Uncertain significance Single submitter
- DCST1 p.Met512Thr Uncertain significance Single submitter
- DCST1 p.Pro42Gln Uncertain significance Single submitter
- DCST1 p.Pro538Leu Uncertain significance Single submitter
- DCST1 p.Pro623Leu Uncertain significance Single submitter
- DCST1 p.Pro626Leu Uncertain significance Single submitter
- DCST1 p.Ser179Gly Uncertain significance Single submitter
- DCST1 p.Thr208Arg Uncertain significance Single submitter
- DCST1 p.Trp372Arg Uncertain significance Single submitter
- DCST1 p.Trp641Arg Uncertain significance Single submitter
- DCST1 p.Tyr129Phe Uncertain significance Single submitter
- DCST1 p.Tyr658His Uncertain significance Single submitter
- DCST1 p.Val276Ile Uncertain significance Single submitter
- DCST1 p.Val359Leu Uncertain significance Single submitter
- DCST1 p.Val379Leu Uncertain significance Single submitter
- DCST1 p.Val440Ile Uncertain significance Single submitter
Predictors split 51
The independent predictors disagree with each other — read with care.
- DCST1 p.Thr158Ile Benign Multiple submitters
- DCST1 p.Ala580Val Uncertain significance Single submitter
- DCST1 p.Arg159Cys Uncertain significance Single submitter
- DCST1 p.Arg159His Uncertain significance Single submitter
- DCST1 p.Arg163Cys Uncertain significance Single submitter
- DCST1 p.Arg188Trp Uncertain significance Single submitter
- DCST1 p.Arg225Cys Uncertain significance Single submitter
- DCST1 p.Arg225His Likely benign Single submitter
- DCST1 p.Arg265Cys Uncertain significance Single submitter
- DCST1 p.Arg265His Likely benign Single submitter
- DCST1 p.Arg304Cys Uncertain significance Single submitter
- DCST1 p.Arg306Cys Uncertain significance Single submitter
- DCST1 p.Arg325Cys Uncertain significance Single submitter
- DCST1 p.Arg354Cys Uncertain significance Single submitter
- DCST1 p.Arg354Pro Uncertain significance Single submitter
- DCST1 p.Arg365His Likely benign Single submitter
- DCST1 p.Arg369Gln Likely benign Single submitter
- DCST1 p.Arg40His Uncertain significance Single submitter
- DCST1 p.Arg518Gln Uncertain significance Single submitter
- DCST1 p.Arg639Ser Uncertain significance Single submitter
- DCST1 p.Arg678Pro Uncertain significance Single submitter
- DCST1 p.Asp264His Uncertain significance Single submitter
- DCST1 p.Asp318Asn Uncertain significance Single submitter
- DCST1 p.Asp318Tyr Uncertain significance Single submitter
- DCST1 p.Asp361His Uncertain significance Single submitter
- DCST1 p.Cys635Tyr Uncertain significance Single submitter
- DCST1 p.Glu459Lys Uncertain significance Single submitter
- DCST1 p.Gly63Asp Uncertain significance Single submitter
- DCST1 p.His632Asn Uncertain significance Single submitter
- DCST1 p.Ile521Thr Uncertain significance Single submitter
- DCST1 p.Leu183Gln Uncertain significance Single submitter
- DCST1 p.Leu52Arg Uncertain significance Single submitter
- DCST1 p.Leu599Val Uncertain significance Single submitter
- DCST1 p.Leu631Pro Uncertain significance Single submitter
- DCST1 p.Lys174Met Uncertain significance Single submitter
- DCST1 p.Lys288Gln Uncertain significance Single submitter
- DCST1 p.Pro443Ser Uncertain significance Single submitter
- DCST1 p.Ser146Leu Uncertain significance Single submitter
- DCST1 p.Ser235Leu Uncertain significance Single submitter
- DCST1 p.Ser249Cys Uncertain significance Single submitter
- DCST1 p.Ser392Phe Uncertain significance Single submitter
- DCST1 p.Ser398Gly Uncertain significance Single submitter
- DCST1 p.Ser691Phe Uncertain significance Single submitter
- DCST1 p.Thr158Ala Uncertain significance Single submitter
- DCST1 p.Thr166Ile Uncertain significance Single submitter
- DCST1 p.Thr280Ile Uncertain significance Single submitter
- DCST1 p.Thr428Ser Uncertain significance Single submitter
- DCST1 p.Val363Ala Uncertain significance Single submitter
- DCST1 p.Val457Met Uncertain significance Single submitter
- DCST1 p.Val507Phe Uncertain significance Single submitter
- DCST1 p.Val668Met Uncertain significance Single submitter
All DCST1 variants
Benign 2
- p.Ala199Val Multiple submitters
- p.Thr158Ile Multiple submitters ⚠
Benign/Likely benign 1
- p.Tyr362= Multiple submitters
Likely benign 9
- p.Arg225His Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg325His Single submitter
- p.Arg365His Single submitter ⚠
- p.Arg369Gln Single submitter ⚠
- p.Arg618Gln Single submitter
- p.Asn305Ser Single submitter
- p.Gly12Arg Single submitter
- p.Leu50Phe Single submitter
Uncertain significance 117
- p.Ala103Thr Single submitter ⚠
- p.Ala124Pro Single submitter ⚠
- p.Ala124Thr Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala391Ser Single submitter ⚠
- p.Ala450Ser Single submitter ⚠
- p.Ala580Val Single submitter ⚠
- p.Ala612Thr Single submitter ⚠
- p.Arg117Ser Single submitter ⚠
- p.Arg14Lys Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg159His Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg163Cys Single submitter ⚠
- p.Arg163Pro Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg260His Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg325Cys Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg354Pro Single submitter ⚠
- p.Arg404His Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg518Gln Single submitter ⚠
- p.Arg616Gln Single submitter ⚠
- p.Arg639Ser Single submitter ⚠
- p.Arg678Pro Single submitter ⚠
- p.Asn142Lys Single submitter ⚠
- p.Asn407Ile Single submitter ⚠
- p.Asn70Lys Single submitter ⚠
- p.Asp175Glu Single submitter ⚠
- p.Asp211Gly Single submitter ⚠
- p.Asp264His Single submitter ⚠
- p.Asp318Asn Single submitter ⚠
- p.Asp318Tyr Single submitter ⚠
- p.Asp361His Single submitter ⚠
- p.Asp418Asn Single submitter ⚠
- p.Asp477Glu Single submitter ⚠
- p.Asp485His Single submitter ⚠
- p.Cys635Tyr Single submitter ⚠
- p.Cys646Tyr Single submitter ⚠
- p.Cys665Tyr Single submitter ⚠
- p.Cys670Tyr Single submitter ⚠
- p.Gln13Glu Single submitter ⚠
- p.Gln322His Single submitter ⚠
- p.Gln41His Single submitter ⚠
- p.Gln619Arg Single submitter ⚠
- p.Gln7Pro Single submitter ⚠
- p.Glu459Lys Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly148Asp Single submitter ⚠
- p.Gly344Glu Single submitter ⚠
- p.Gly375Arg Single submitter ⚠
- p.Gly58Val Single submitter ⚠
- p.Gly634Ser Single submitter ⚠
- p.Gly63Asp Single submitter ⚠
- p.His138Gln Single submitter ⚠
- p.His501Asn Single submitter ⚠
- p.His632Asn Single submitter ⚠
- p.Ile164Ser Single submitter ⚠
- p.Ile190Met Single submitter ⚠
- p.Ile256Met Single submitter ⚠
- p.Ile441Thr Single submitter ⚠
- p.Ile487Val Single submitter ⚠
- p.Ile521Thr Single submitter ⚠
- p.Ile62Leu Single submitter ⚠
- p.Ile62Met Single submitter ⚠
- p.Leu183Gln Single submitter ⚠
- p.Leu183Pro Single submitter ⚠
- p.Leu30Val Single submitter ⚠
- p.Leu470Val Single submitter ⚠
- p.Leu52Arg Single submitter ⚠
- p.Leu598Val Single submitter ⚠
- p.Leu599Val Single submitter ⚠
- p.Leu631Pro Single submitter ⚠
- p.Lys174Met Single submitter ⚠
- p.Lys288Gln Single submitter ⚠
- p.Lys588Asn Single submitter ⚠
- p.Met239Leu Single submitter ⚠
- p.Met271Val Single submitter ⚠
- p.Met512Ile Single submitter ⚠
- p.Met512Thr Single submitter ⚠
- p.Pro42Gln Single submitter ⚠
- p.Pro443Ser Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro623Leu Single submitter ⚠
- p.Pro626Leu Single submitter ⚠
- p.Ser146Leu Single submitter ⚠
- p.Ser179Gly Single submitter ⚠
- p.Ser235Leu Single submitter ⚠
- p.Ser249Cys Single submitter ⚠
- p.Ser392Phe Single submitter ⚠
- p.Ser398Gly Single submitter ⚠
- p.Ser691Phe Single submitter ⚠
- p.Thr158Ala Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Thr208Arg Single submitter ⚠
- p.Thr280Ile Single submitter ⚠
- p.Thr428Ser Single submitter ⚠
- p.Trp372Arg Single submitter ⚠
- p.Trp641Arg Single submitter ⚠
- p.Tyr129Phe Single submitter ⚠
- p.Tyr658His Single submitter ⚠
- p.Val276Ile Single submitter ⚠
- p.Val359Leu Single submitter ⚠
- p.Val363Ala Single submitter ⚠
- p.Val379Leu Single submitter ⚠
- p.Val440Ile Single submitter ⚠
- p.Val457Met Single submitter ⚠
- p.Val507Phe Single submitter ⚠
- p.Val668Met Single submitter ⚠