EGFR p.Asp855=
c.2565T>C · VCV3773413
Benign
Single submitter
Classification
Benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Absent
absent from gnomAD v4.1
Conditions
1
lung cancer
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -0.23 | GERP -3.8, phastCons 0.47 |
| Overall | ||
| CADD | 7.745 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- EGFR
- Protein
- p.Asp855=
- Coding
- c.2565T>C
- MANE Select
- NM_005228
- Type
- single nucleotide variant
- Location
- chr7:55191814 (GRCh38)
- Gene constraint
- LOEUF 0.475 · pLI 0.98 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 76.29 · 393 PDB
- Residue 855
- a binding site; the protein kinase domain
Similar variants
- EGFR p.Arg1031Gln Uncertain significance ★★ ⚠ same condition
- EGFR p.Arg165Trp Uncertain significance ★★ ⚠ same condition
- EGFR p.Arg671His Uncertain significance ★★ ⚠ same condition
- EGFR p.Arg831Cys Uncertain significance ★★ ⚠ same condition
- EGFR p.Arg999His Uncertain significance ★★ ⚠ same condition
- EGFR p.Asp1006Ala Uncertain significance ★★ ⚠ same condition
- EGFR p.Asp1012His Uncertain significance ★★ ⚠ same condition
- EGFR p.Gln1159Arg Uncertain significance ★★ ⚠ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/egfr-p-asp855 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown