EGFR — 3595 ClinVar variants

All ClinVar germline EGFR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1764 flagged for review →

60 Pathogenic · 37 Likely pathogenic · 222 Conflicting · 92 Benign · 101 Benign/Likely benign · 1317 Likely benign · 1766 Uncertain significance

Full EGFR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1764

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

EGFR p.Ile646Phe Likely pathogenic Single submitter
ovarian cancer

Predictors agree, ClinVar conflicts 113

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

EGFR p.Ala1048Val Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Ala1102Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala1118Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala1118Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala1201Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala1210Val Conflicting Single submitter
diffuse midline glioma, H3 K27-altered
EGFR p.Ala127Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala127Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala13Val Conflicting Single submitter
lung cancer
EGFR p.Ala155Asp Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala17Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala21Ser Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Ala21Thr Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Ala313Val Conflicting Single submitter
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Ala409Ser Conflicting Single submitter
EGFR-related disorder
EGFR p.Ala613Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ala722Val Conflicting Single submitter
lung cancer
EGFR p.Ala840Thr Conflicting Single submitter
lung cancer
EGFR p.Arg165Gln Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Arg334His Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Arg334Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Arg574Gln Conflicting Single submitter
EGFR-related disorder
EGFR p.Arg675Gln Conflicting Single submitter
lung cancer
EGFR p.Arg776His Conflicting Single submitter
lung cancer
EGFR p.Arg831His Conflicting Single submitter
squamous cell lung carcinoma
EGFR p.Arg836Cys Conflicting Single submitter
lung cancer
EGFR p.Arg962His Conflicting Single submitter
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Arg98Gln Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn1112Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn1140Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn115Lys Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn1184Lys Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn1184Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn444Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn497Lys Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn639Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asn996Lys Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Asp1008Glu Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Asp1080Asn Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asp1152Asn Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Asp770Glu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gln1143Glu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gln581Lys Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gln71Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Glu204Lys Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Glu282Asp Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Glu282Lys Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Glu513Ala Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Glu519Asp Conflicting Single submitter
lung cancer
EGFR p.Gly1134Asp Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gly1134Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gly485Ser Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Gly614Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gly614Asp Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gly614Ser Conflicting Single submitter
lung carcinoma
EGFR p.Gly796Ser Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Gly8Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.His1156Pro Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.His145Arg Conflicting Single submitter
EGFR-related lung cancer
EGFR p.His145Asn Conflicting Single submitter
EGFR-related lung cancer
EGFR p.His590Gln Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.His615Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile1018Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile1050Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile1050Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile1082Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile1082Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile351Val Conflicting Single submitter
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Ile491Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile569Val Conflicting Single submitter
ovarian cancer
EGFR p.Ile580Thr Conflicting Single submitter
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Ile646Leu Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Ile664Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ile966Val Conflicting Single submitter
lung carcinoma
EGFR p.Leu184Gln Conflicting Single submitter
lung carcinoma
EGFR p.Leu184Pro Conflicting Single submitter
lung carcinoma
EGFR p.Leu184Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Leu730Arg Conflicting Single submitter
lung cancer
EGFR p.Lys253Arg Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Lys713Thr Conflicting Single submitter
lung cancer
EGFR p.Met111Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Met137Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Met178Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Met600Thr Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Met600Val Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Phe1177Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Pro1183Thr Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Pro20Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Pro3Leu Conflicting Single submitter
lung cancer
EGFR p.Pro3Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Pro512Ser Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Pro753Leu Conflicting Single submitter
lung cancer
EGFR p.Pro848Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ser1057Asn Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Ser442Asn Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Thr1046Asn Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Thr1191Ala Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Thr1191Ile Conflicting Single submitter
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Thr594Asn Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Thr6Ala Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Trp731Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Tyr801Cys Conflicting Single submitter
lung cancer
EGFR p.Val1010Met Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Val1097Ile Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Val1097Leu Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Val159Met Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Val323Ile Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Val524Ile Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Val550Met Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Val674Ile Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Val765Met Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.His835Leu Conflicting No assertion criteria
lung adenocarcinoma
EGFR p.Leu833Val Conflicting No assertion criteria
lung adenocarcinoma

Predicted LoF vs a conflicting call 21

ClinVar submitters conflict, and it's a predicted loss-of-function change in a gene where LoF causes disease — flagged for review, not resolved (verify NMD-escape for C-terminal truncations). Non-missense.

EGFR c.1631+1G>A Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.1881-2A>C Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.1881-2A>G Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.2061+2T>C Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.3115-1G>A Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.3162+1G>A Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.628+1G>A Conflicting Single submitter
EGFR-related lung cancer
EGFR c.747+1G>A Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.88+2T>G Conflicting Single submitter
hereditary neoplastic syndrome
EGFR c.889+1G>A Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Arg255Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Arg309Ter Conflicting Single submitter
cerebral palsy
EGFR p.Arg531Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Arg98Ter Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Gln52Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gln71Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Gln849Ter Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Glu513Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Glu931Ter Conflicting Single submitter
EGFR-related lung cancer
EGFR p.Trp905Ter Conflicting Single submitter
hereditary neoplastic syndrome
EGFR p.Tyr117Ter Conflicting Single submitter
EGFR-related lung cancer

Predictors lean, ClinVar uncertain 980

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 980

EGFR p.Ala1040Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1076Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1076Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala118Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1192Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1201Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1201Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala147Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala147Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala21Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala501Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala597Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala647Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala647Thr Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala702Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala743Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala763Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala767Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala767Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala7Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala822Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala864Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala864Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala955Thr Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala972Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala972Thr Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg1031Gln Uncertain significance Multiple submitters
lung cancer
EGFR p.Arg1031Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg1100Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg1121Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg149Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg165Leu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg165Trp Uncertain significance Multiple submitters
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Arg222Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg224His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg244Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg252Cys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg255Gln Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg427Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg53Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg547Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg677Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg680Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg705Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg705Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg776Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg803Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg836His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg932Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg958Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg958His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg973Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg973Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg977Cys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg977His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg977Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn1043Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn1112His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn1148Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn152Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn158Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asn196Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn234Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asn623Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn639Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asn639Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn808Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn996Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1012His Uncertain significance Multiple submitters
lung cancer
EGFR p.Asp1051Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1063Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1072Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1080Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp1083Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp1084Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1122Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp1152Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1152His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1175Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp256Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp46Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp46Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp522Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp761Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp761His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp942Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp942His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp974Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp974Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Cys1146Phe Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Cys1146Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Cys236Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Cys591Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Cys775Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln1020His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln1056His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln1067Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln1106Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln1143His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln1143Pro Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln1159Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln188Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln408Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln40Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln565Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln684Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln684Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln71Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln894His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1079Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu1180Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu245Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu344Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu513Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu519Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu685Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu829Gln Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu84Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu84Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu866Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu928Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu963Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu967Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1022Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly1075Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1075Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1075Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly109Ala Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly1103Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly1161Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1161Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1189Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1209Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly221Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly239Ala Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly288Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly343Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly42Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly517Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly544Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly575Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly5Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly5Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly652Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly721Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly724Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly779Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly863Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly873Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly901Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome

Predictors split 649

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 649

EGFR p.Ala10Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala118Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala1192Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala120Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala13Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala238Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala310Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala310Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala472Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala508Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ala611Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala7Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ala822Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg1068Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg1068Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg138Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg149Trp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg222His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg224Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg23Pro Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg244Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg244Trp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg252His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg324His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg324Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg334Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg451Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg451His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg527Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg531Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg574Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg669Gln Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg671Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg671His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg677His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg680Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg803Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg831Cys Uncertain significance Multiple submitters
inflammatory skin and bowel disease, neonatal, 2
EGFR p.Arg832Cys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Arg832His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg962Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg962Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg999Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Arg999His Uncertain significance Multiple submitters
lung cancer
EGFR p.Arg999Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn1107Ser Uncertain significance Multiple submitters
lung carcinoma
EGFR p.Asn1135Tyr Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asn1169Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn139Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn413Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn444His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asn540Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn700Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asn73Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1006Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1006His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1008Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1009Asn Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp1014Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1072Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1072Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp1084Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp191Glu Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp314Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp321Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp612Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp75Ala Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp807Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp916Asn Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Asp956Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Asp994Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln105His Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln1173Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln276Arg Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln557Arg Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln701Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gln791His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln976Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gln982Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1004Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1015Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu1091Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1137Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1137Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu114Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu1193Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu205Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu319Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu412Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu545Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu551Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu554Gly Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu59Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu634Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu709Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu758Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu804Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu865Lys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Glu922Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Glu922Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly1185Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly305Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly322Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly434Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly485Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly485Cys Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly503Asp Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly503Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly544Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly588Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly627Arg Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly635Ser Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Gly63Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Gly8Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.His584Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.His584Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.His888Gln Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ile106Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile167Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile167Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile214Thr Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ile394Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile407Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile426Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile445Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ile462Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile475Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile556Met Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ile744Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile759Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile821Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Ile82Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile886Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Ile926Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu1034Pro Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu11Phe Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu132Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu132Val Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu25Pro Uncertain significance Multiple submitters
lung cancer
EGFR p.Leu448Phe Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu480Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu480Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu509Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu541Arg Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu541Phe Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu62Phe Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu666Phe Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu703Ile Uncertain significance Multiple submitters
EGFR-related lung cancer
EGFR p.Leu703Phe Uncertain significance Multiple submitters
hereditary neoplastic syndrome
EGFR p.Leu76Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome

All EGFR variants

Pathogenic 60

p.Ala147fs Single submitter EGFR-related lung cancer
p.Ala698fs Single submitter EGFR-related lung cancer
p.Arg297fs Single submitter EGFR-related lung cancer
p.Arg669Ter Single submitter EGFR-related lung cancer
p.Arg973Ter Single submitter EGFR-related lung cancer
p.Arg986fs Single submitter EGFR-related lung cancer
p.Asn473fs Single submitter EGFR-related lung cancer
p.Asn73fs Single submitter EGFR-related lung cancer
p.Asn771_Pro772insHis Single submitter non-small cell lung carcinoma
p.Asp974fs Single submitter EGFR-related lung cancer
p.Cys1049Ter Single submitter EGFR-related lung cancer
p.Cys535Ter Single submitter EGFR-related lung cancer
p.Cys620_His621delinsTer Single submitter EGFR-related lung cancer
p.Gln1021Ter Single submitter EGFR-related lung cancer
p.Gln71fs Single submitter EGFR-related lung cancer
p.Gln791Ter Single submitter EGFR-related lung cancer
p.Gln976fs Single submitter EGFR-related lung cancer
p.Glu513fs Single submitter EGFR-related lung cancer
p.Glu548fs Single submitter EGFR-related lung cancer
p.Glu634fs Single submitter EGFR-related lung cancer
p.Glu709_Thr710delinsAsp Single submitter non-small cell lung carcinoma
p.Glu884Ter Single submitter EGFR-related lung cancer
p.Gly242fs Single submitter EGFR-related lung cancer
p.Gly428Asp Single submitter EGFR-related lung cancer
p.Gly719Ala Single submitter non-small cell lung carcinoma
p.His773delinsAsnProTyr Single submitter lung cancer
p.Ile213fs Single submitter EGFR-related lung cancer
p.Leu119fs Single submitter EGFR-related lung cancer
p.Leu267fs Single submitter EGFR-related lung cancer
p.Leu38fs Single submitter EGFR-related lung cancer
p.Leu405fs Single submitter EGFR-related lung cancer
p.Leu907Ter Single submitter EGFR-related lung cancer
p.Lys293Ter Single submitter EGFR-related lung cancer
p.Lys294fs Single submitter EGFR-related lung cancer
p.Lys325_Cys326insTer Single submitter EGFR-related lung cancer
p.Lys860fs Single submitter EGFR-related lung cancer
p.Phe44fs Single submitter EGFR-related lung cancer
p.Phe481fs Single submitter EGFR-related lung cancer
p.Ser1071Ter Single submitter EGFR-related lung cancer
p.Ser437fs Single submitter EGFR-related lung cancer
p.Ser768_Val769delinsIleLeu Single submitter non-small cell lung carcinoma
p.Ser768Ile Single submitter non-small cell lung carcinoma
p.Thr384fs Single submitter EGFR-related lung cancer
p.Trp164_Asp171delinsTer Single submitter EGFR-related lung cancer
p.Trp477Ter Single submitter EGFR-related lung cancer
p.Trp608Ter Single submitter EGFR-related lung cancer
p.Trp817Ter Single submitter EGFR-related lung cancer
p.Trp951Ter Single submitter EGFR-related lung cancer
p.Tyr113Ter Single submitter EGFR-related lung cancer
p.Tyr764fs Single submitter EGFR-related lung cancer
p.Tyr827fs Single submitter EGFR-related lung cancer
p.Tyr915Ter Single submitter EGFR-related lung cancer
p.Val461fs Single submitter EGFR-related lung cancer
p.Ala763Thr No assertion criteria urinary bladder cancer
p.Asp770_Asn771insGlyLeu No assertion criteria non-small cell lung carcinoma
p.Cys326Phe No assertion criteria Cowden syndrome 1
p.Gly598Arg No assertion criteria urinary bladder cancer
p.Ile365Asn No assertion criteria inflammatory skin and bowel disease, neonatal, 2
p.Pro596Ser No assertion criteria urinary bladder cancer
p.Thr854Ile No assertion criteria urinary bladder cancer

Likely pathogenic 37

c.1007-1G>A Single submitter EGFR-related lung cancer
c.1498+1G>T Single submitter EGFR-related lung cancer
c.1723-2A>G Single submitter EGFR-related lung cancer
c.1919+1G>A Single submitter EGFR-related lung cancer
c.1919+2T>G Single submitter EGFR-related lung cancer
c.2061+1G>A Single submitter EGFR-related lung cancer
c.2061+2T>A Single submitter EGFR-related lung cancer
c.2181_2184+7del Single submitter EGFR-related lung cancer
c.2284-5_2290dup Single submitter non-small cell lung carcinoma
c.240+1G>A Single submitter EGFR-related lung cancer
c.2469+1G>A Single submitter EGFR-related lung cancer
c.2555_2626-421del Single submitter EGFR-related lung cancer
c.2947-1G>A Single submitter EGFR-related lung cancer
c.2947-1G>T Single submitter EGFR-related lung cancer
c.2947-2A>G Single submitter EGFR-related lung cancer
c.3162+1G>T Single submitter EGFR-related lung cancer
c.3163-2A>G Single submitter EGFR-related lung cancer
c.560-1G>T Single submitter EGFR-related lung cancer
c.628+1del Single submitter EGFR-related lung cancer
c.628+1G>T Single submitter EGFR-related lung cancer
c.629-2A>G Single submitter EGFR-related lung cancer
c.748-1G>A Single submitter EGFR-related lung cancer
p.Asp770delinsGluSer Single submitter lung adenocarcinoma
p.His773_Val774insAlaHis Single submitter non-small cell lung carcinoma
p.Ile646Phe Single submitter ovarian cancer ⚠
p.Ile941fs Single submitter lung cancer
p.Lys716fs Single submitter
p.Ala237Phe No assertion criteria lung adenocarcinoma
p.Glu746del No assertion criteria lip and oral cavity carcinoma
p.His773_Val774delinsLeuMet No assertion criteria lung adenocarcinoma
p.His773_Val774dup No assertion criteria non-small cell lung carcinoma
p.His773_Val774insGlyHis No assertion criteria non-small cell lung carcinoma
p.Leu747_Ala750delinsSer No assertion criteria non-small cell lung carcinoma
p.Leu747_Ser752delinsGln No assertion criteria lung adenocarcinoma
p.Leu833Phe No assertion criteria lung adenocarcinoma ⚠
p.Lys852Thr No assertion criteria lung adenocarcinoma
p.Thr751_Ile759delinsAsn No assertion criteria lung adenocarcinoma

Conflicting classifications of pathogenicity 222

c.1499-5C>T Single submitter hereditary neoplastic syndrome
c.1631+1G>A Single submitter hereditary neoplastic syndrome ⚠
c.1632-5C>G Single submitter hereditary neoplastic syndrome
c.1632-5C>T Single submitter hereditary neoplastic syndrome
c.1881-2A>C Single submitter hereditary neoplastic syndrome ⚠
c.1881-2A>G Single submitter hereditary neoplastic syndrome ⚠
c.1881-858G>T Single submitter hereditary neoplastic syndrome
c.2061+2T>C Single submitter hereditary neoplastic syndrome ⚠
c.2062-3del Single submitter lung cancer
c.2062-5C>G Single submitter hereditary neoplastic syndrome
c.2185-3T>C Single submitter lung cancer
c.2185-5C>T Single submitter hereditary neoplastic syndrome
c.2284-4C>G Single submitter hereditary neoplastic syndrome
c.2469+6C>A Single submitter lung cancer
c.2469+8G>A Single submitter lung cancer
c.2702-5C>T Single submitter hereditary neoplastic syndrome
c.2849-5C>T Single submitter hereditary neoplastic syndrome
c.3115-1G>A Single submitter hereditary neoplastic syndrome ⚠
c.3162+1G>A Single submitter hereditary neoplastic syndrome ⚠
c.3163-5T>C Single submitter EGFR-related lung cancer
c.425-12A>G Single submitter hereditary neoplastic syndrome
c.425-5C>T Single submitter EGFR-related lung cancer
c.560_567delGCCAAAAG Single submitter EGFR-related lung cancer
c.628+1G>A Single submitter EGFR-related lung cancer ⚠
c.747+1G>A Single submitter hereditary neoplastic syndrome ⚠
c.88+2T>G Single submitter hereditary neoplastic syndrome ⚠
c.889+18G>T Single submitter EGFR-related lung cancer
c.889+1G>A Single submitter EGFR-related lung cancer ⚠
c.890-3del Single submitter hereditary neoplastic syndrome
p.Ala1048Val Single submitter EGFR-related lung cancer ⚠
p.Ala1102Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala1118Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala1118Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala1201Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala1210Val Single submitter diffuse midline glioma, H3 K27-altered ⚠
p.Ala127Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala127Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala13Thr Single submitter EGFR-related lung cancer ⚠
p.Ala13Val Single submitter lung cancer ⚠
p.Ala155Asp Single submitter hereditary neoplastic syndrome ⚠
p.Ala17Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala21Ser Single submitter EGFR-related lung cancer ⚠
p.Ala21Thr Single submitter EGFR-related lung cancer ⚠
p.Ala24Thr Single submitter EGFR-related lung cancer ⚠
p.Ala313Val Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Ala409Ser Single submitter EGFR-related disorder ⚠
p.Ala611Thr Single submitter EGFR-related lung cancer ⚠
p.Ala613Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala722Val Single submitter lung cancer ⚠
p.Ala840Thr Single submitter lung cancer ⚠
p.Ala9Thr Single submitter hereditary neoplastic syndrome ⚠
p.Arg165Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg23Trp Single submitter EGFR-related lung cancer ⚠
p.Arg255Ter Single submitter hereditary neoplastic syndrome ⚠
p.Arg309Ter Single submitter cerebral palsy ⚠
p.Arg334His Single submitter hereditary neoplastic syndrome ⚠
p.Arg334Leu Single submitter hereditary neoplastic syndrome ⚠
p.Arg527Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg527Trp Single submitter EGFR-related lung cancer ⚠
p.Arg531Ter Single submitter hereditary neoplastic syndrome ⚠
p.Arg574Gln Single submitter EGFR-related disorder ⚠
p.Arg675Gln Single submitter lung cancer ⚠
p.Arg776His Single submitter lung cancer ⚠
p.Arg831His Single submitter squamous cell lung carcinoma ⚠
p.Arg836Cys Single submitter lung cancer ⚠
p.Arg962His Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Arg98Gln Single submitter hereditary neoplastic syndrome ⚠
p.Arg98Ter Single submitter EGFR-related lung cancer ⚠
p.Asn1112Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn1135Lys Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Asn1140Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn115Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn1184Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn1184Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn444Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn473Asp Single submitter EGFR-related lung cancer ⚠
p.Asn476Ser Single submitter EGFR-related lung cancer ⚠
p.Asn497Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn528Asp Single submitter hereditary neoplastic syndrome ⚠
p.Asn540Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn552Ser Single submitter EGFR-related lung cancer ⚠
p.Asn603Lys Single submitter hereditary neoplastic syndrome ⚠
p.Asn604Ser Single submitter EGFR-related lung cancer ⚠
p.Asn639Ser Single submitter hereditary neoplastic syndrome ⚠
p.Asn816= Single submitter EGFR-related lung cancer
p.Asn996Lys Single submitter EGFR-related lung cancer ⚠
p.Asp1008Glu Single submitter EGFR-related lung cancer ⚠
p.Asp1080Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp1152Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp247Asn Single submitter hereditary neoplastic syndrome ⚠
p.Asp770Asn Single submitter EGFR-related lung cancer ⚠
p.Asp770Glu Single submitter hereditary neoplastic syndrome ⚠
p.Cys535= Single submitter hereditary neoplastic syndrome
p.Gln1143Glu Single submitter hereditary neoplastic syndrome ⚠
p.Gln408= Single submitter hereditary neoplastic syndrome
p.Gln504Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gln504His Single submitter hereditary neoplastic syndrome ⚠
p.Gln52Ter Single submitter hereditary neoplastic syndrome ⚠
p.Gln581Lys Single submitter hereditary neoplastic syndrome ⚠
p.Gln71Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gln71Ter Single submitter hereditary neoplastic syndrome ⚠
p.Gln849Ter Single submitter EGFR-related lung cancer ⚠
p.Gln982Leu Single submitter hereditary neoplastic syndrome ⚠
p.Glu204Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu257Lys Single submitter hereditary neoplastic syndrome ⚠
p.Glu282Asp Single submitter hereditary neoplastic syndrome ⚠
p.Glu282Lys Single submitter EGFR-related lung cancer ⚠
p.Glu330Lys Single submitter lung adenocarcinoma ⚠
p.Glu513Ala Single submitter hereditary neoplastic syndrome ⚠
p.Glu513Ter Single submitter hereditary neoplastic syndrome ⚠
p.Glu519Asp Single submitter lung cancer ⚠
p.Glu634Lys Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Glu746_Ala750del Single submitter EGFR-related lung cancer
p.Glu884= Single submitter EGFR-related lung cancer
p.Glu931Ter Single submitter EGFR-related lung cancer ⚠
p.Gly1134Asp Single submitter hereditary neoplastic syndrome ⚠
p.Gly1134Ser Single submitter hereditary neoplastic syndrome ⚠
p.Gly221Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly485Ser Single submitter EGFR-related lung cancer ⚠
p.Gly614Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly614Asp Single submitter hereditary neoplastic syndrome ⚠
p.Gly614Ser Single submitter lung carcinoma ⚠
p.Gly640= Single submitter EGFR-related lung cancer
p.Gly665Ser Single submitter EGFR-related lung cancer ⚠
p.Gly724= Single submitter hereditary neoplastic syndrome
p.Gly796Ser Single submitter EGFR-related lung cancer ⚠
p.Gly873= Single submitter lung cancer
p.Gly8Arg Single submitter hereditary neoplastic syndrome ⚠
p.His1156Pro Single submitter hereditary neoplastic syndrome ⚠
p.His145Arg Single submitter EGFR-related lung cancer ⚠
p.His145Asn Single submitter EGFR-related lung cancer ⚠
p.His590Gln Single submitter hereditary neoplastic syndrome ⚠
p.His615Arg Single submitter hereditary neoplastic syndrome ⚠
p.His615Tyr Single submitter EGFR-related lung cancer ⚠
p.Ile1018Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile1050Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ile1050Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile1082Arg Single submitter hereditary neoplastic syndrome ⚠
p.Ile1082Leu Single submitter hereditary neoplastic syndrome ⚠
p.Ile351Val Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Ile491Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile569Val Single submitter ovarian cancer ⚠
p.Ile580Thr Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Ile646Leu Single submitter EGFR-related lung cancer ⚠
p.Ile664Val Single submitter hereditary neoplastic syndrome ⚠
p.Ile878= Single submitter hereditary neoplastic syndrome
p.Ile966Val Single submitter lung carcinoma ⚠
p.Leu184Gln Single submitter lung carcinoma ⚠
p.Leu184Pro Single submitter lung carcinoma ⚠
p.Leu184Val Single submitter hereditary neoplastic syndrome ⚠
p.Leu18Phe Single submitter hereditary neoplastic syndrome ⚠
p.Leu395= Single submitter EGFR-related lung cancer
p.Leu448= Single submitter EGFR-related lung cancer
p.Leu542= Single submitter hereditary neoplastic syndrome
p.Leu606Val Single submitter hereditary neoplastic syndrome ⚠
p.Leu666= Single submitter hereditary neoplastic syndrome
p.Leu730Arg Single submitter lung cancer ⚠
p.Lys253Arg Single submitter hereditary neoplastic syndrome ⚠
p.Lys325= Single submitter hereditary neoplastic syndrome
p.Lys538= Single submitter EGFR-related lung cancer
p.Lys713Thr Single submitter lung cancer ⚠
p.Lys757Arg Single submitter hereditary neoplastic syndrome ⚠
p.Lys806Glu Single submitter EGFR-related lung cancer ⚠
p.Met111Thr Single submitter hereditary neoplastic syndrome ⚠
p.Met137Leu Single submitter hereditary neoplastic syndrome ⚠
p.Met178Val Single submitter hereditary neoplastic syndrome ⚠
p.Met600Thr Single submitter EGFR-related lung cancer ⚠
p.Met600Val Single submitter hereditary neoplastic syndrome ⚠
p.Phe1177Leu Single submitter hereditary neoplastic syndrome ⚠
p.Pro1090= Single submitter hereditary neoplastic syndrome
p.Pro1183Thr Single submitter hereditary neoplastic syndrome ⚠
p.Pro20Arg Single submitter EGFR-related lung cancer ⚠
p.Pro20Gln Single submitter lung carcinoma ⚠
p.Pro20Leu Single submitter hereditary neoplastic syndrome ⚠
p.Pro3Leu Single submitter lung cancer ⚠
p.Pro3Ser Single submitter hereditary neoplastic syndrome ⚠
p.Pro512Ser Single submitter hereditary neoplastic syndrome ⚠
p.Pro518Leu Single submitter hereditary neoplastic syndrome ⚠
p.Pro560Ala Single submitter EGFR-related lung cancer ⚠
p.Pro560Thr Single submitter EGFR-related lung cancer ⚠
p.Pro589Leu Single submitter hereditary neoplastic syndrome ⚠
p.Pro631Ser Single submitter EGFR-related lung cancer ⚠
p.Pro753Leu Single submitter lung cancer ⚠
p.Pro848Leu Single submitter hereditary neoplastic syndrome ⚠
p.Ser1057Asn Single submitter hereditary neoplastic syndrome ⚠
p.Ser1166Asn Single submitter hereditary neoplastic syndrome ⚠
p.Ser170Asn Single submitter lung carcinoma ⚠
p.Ser22Asn Single submitter EGFR-related lung cancer ⚠
p.Ser442Asn Single submitter hereditary neoplastic syndrome ⚠
p.Ser4Phe Single submitter hereditary neoplastic syndrome ⚠
p.Ser4Tyr Single submitter hereditary neoplastic syndrome ⚠
p.Ser511Tyr Single submitter hereditary neoplastic syndrome ⚠
p.Thr1046Asn Single submitter EGFR-related lung cancer ⚠
p.Thr1191Ala Single submitter hereditary neoplastic syndrome ⚠
p.Thr1191Ile Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Thr290Ile Single submitter EGFR-related lung cancer ⚠
p.Thr594Asn Single submitter hereditary neoplastic syndrome ⚠
p.Thr6Ala Single submitter hereditary neoplastic syndrome ⚠
p.Trp731Leu Single submitter hereditary neoplastic syndrome ⚠
p.Trp905Ter Single submitter hereditary neoplastic syndrome ⚠
p.Tyr117Ter Single submitter EGFR-related lung cancer ⚠
p.Tyr727Cys Single submitter inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Tyr801Cys Single submitter lung cancer ⚠
p.Val1010Met Single submitter hereditary neoplastic syndrome ⚠
p.Val1097Ile Single submitter EGFR-related lung cancer ⚠
p.Val1097Leu Single submitter hereditary neoplastic syndrome ⚠
p.Val159Met Single submitter hereditary neoplastic syndrome ⚠
p.Val323Ala Single submitter EGFR-related lung cancer ⚠
p.Val323Ile Single submitter hereditary neoplastic syndrome ⚠
p.Val441= Single submitter hereditary neoplastic syndrome
p.Val524Ile Single submitter hereditary neoplastic syndrome ⚠
p.Val550= Single submitter EGFR-related lung cancer
p.Val550Met Single submitter EGFR-related lung cancer ⚠
p.Val607= Single submitter hereditary neoplastic syndrome
p.Val674Ile Single submitter EGFR-related lung cancer ⚠
p.Val742Ile Single submitter diffuse midline glioma, H3 K27-altered ⚠
p.Val765Met Single submitter hereditary neoplastic syndrome ⚠
p.Val769Met Single submitter lung cancer ⚠
p.Val843Ile Single submitter lung cancer ⚠
p.Val845Leu Single submitter hereditary neoplastic syndrome ⚠
p.His835Leu No assertion criteria lung adenocarcinoma ⚠
p.Leu833Val No assertion criteria lung adenocarcinoma ⚠

Benign 92

c.1498+142C>T Multiple submitters
c.1498+22A>T Multiple submitters inflammatory skin and bowel disease, neonatal, 2
c.1880+55C>T Multiple submitters
c.1881-404T>G Multiple submitters
c.1881-600G>A Multiple submitters
c.1881-641C>T Multiple submitters
c.1881-781C>T Multiple submitters
c.1920-215G>C Multiple submitters
c.2061+96G>A Multiple submitters
c.2062-104C>A Multiple submitters
c.2184+100C>T Multiple submitters
c.2184+19G>A Multiple submitters EGFR-related lung cancer
c.2283+96A>G Multiple submitters
c.2284-199T>C Multiple submitters
c.2284-60T>C Multiple submitters
c.240+58G>A Multiple submitters
c.2469+19T>C Multiple submitters EGFR-related lung cancer
c.2470-115A>G Multiple submitters
c.2626-101G>C Multiple submitters
c.2626-118C>G Multiple submitters
c.2626-19C>T Multiple submitters EGFR-related lung cancer
c.2702-183C>T Multiple submitters
c.2946+191C>T Multiple submitters
c.2946+194A>C Multiple submitters
c.3115-164T>G Multiple submitters
c.3162+36C>T Multiple submitters
c.3163-90A>G Multiple submitters
c.3271+293T>G Multiple submitters
c.3272-123G>A Multiple submitters
c.3272-295T>C Multiple submitters
c.559+102A>T Multiple submitters
c.559+10G>A Multiple submitters lung cancer
c.559+214G>T Multiple submitters
c.560-238G>A Multiple submitters
c.560-84T>C Multiple submitters
c.628+104C>T Multiple submitters
c.629-62A>G Multiple submitters
c.748-49G>A Multiple submitters
c.88+81G>T Multiple submitters
c.89-17723A>C Multiple submitters EGFR-related lung cancer
c.*774T>C Multiple submitters
p.Arg521Lys Multiple submitters lung cancer
p.Asn158= Multiple submitters lung cancer
p.Asp994= Multiple submitters lung cancer
p.Gln787= Multiple submitters inflammatory skin and bowel disease, neonatal, 2
c.1006+151T>C Single submitter
c.1208-186G>C Single submitter
c.1208-216G>C Single submitter
c.1208-244del Single submitter
c.1499-15A>G Single submitter EGFR-related lung cancer
c.1499-177A>G Single submitter
c.1631+219T>C Single submitter
c.1723-247G>T Single submitter
c.1881-2848T>C Single submitter
c.1881-488A>G Single submitter
c.1919+258G>A Single submitter
c.1920-248A>G Single submitter
c.2061+17G>A Single submitter EGFR-related lung cancer
c.2061+190A>G Single submitter
c.2061+291G>C Single submitter
c.2184+297G>A Single submitter
c.2185-252G>A Single submitter
c.2283+125T>C Single submitter
c.2283+269T>C Single submitter
c.241-265G>C Single submitter
c.2625+196A>G Single submitter
c.2626-173G>A Single submitter
c.2848+201C>T Single submitter
c.2849-261A>T Single submitter
c.3114+12C>T Single submitter EGFR-related lung cancer
c.3114+15TC[7] Single submitter EGFR-related lung cancer
c.3114+15TC[9] Single submitter EGFR-related lung cancer
c.3162+200_3162+201insAG Single submitter
c.3163-334G>A Single submitter
c.424+135G>A Single submitter
c.628+235T>C Single submitter
c.628+252C>G Single submitter
c.748-235C>T Single submitter
c.748-257C>G Single submitter
c.89-267T>C Single submitter
c.89-8del Single submitter EGFR-related lung cancer
c.*294dup Single submitter
p.Asp855= Single submitter lung cancer
p.Gln787_Leu788= Single submitter lung cancer
p.Glu690= Single submitter lung cancer
p.Leu777= Single submitter lung cancer
p.Leu798= Single submitter lung cancer
p.Leu799= Single submitter lung cancer
p.Leu862= Single submitter lung cancer
p.Ser1120Arg Single submitter ovarian cancer
p.Thr625Pro Single submitter ovarian cancer ⚠
p.Tyr801= Single submitter lung cancer

Benign/Likely benign 101

c.1299-7A>G Multiple submitters lung cancer
c.1881-721G>A Multiple submitters
c.2062-3dup Multiple submitters EGFR-related lung cancer
c.2284-13T>C Multiple submitters lung cancer
c.2284-20G>A Multiple submitters lung cancer
c.241-4T>G Multiple submitters hereditary neoplastic syndrome
c.241-8C>G Multiple submitters hereditary neoplastic syndrome
c.2626-5C>T Multiple submitters hereditary neoplastic syndrome
c.-191A>C Multiple submitters lung cancer
c.-216G>T Multiple submitters lung cancer
p.Ala439= Multiple submitters hereditary neoplastic syndrome
p.Ala583= Multiple submitters EGFR-related lung cancer
p.Ala698= Multiple submitters EGFR-related lung cancer
p.Ala743= Multiple submitters lung cancer
p.Ala822= Multiple submitters lung cancer
p.Ala840= Multiple submitters lung cancer
p.Ala859= Multiple submitters EGFR-related lung cancer
p.Ala864= Multiple submitters lung cancer
p.Ala871= Multiple submitters hereditary neoplastic syndrome
p.Arg776= Multiple submitters EGFR-related lung cancer
p.Arg803= Multiple submitters lung cancer
p.Arg831= Multiple submitters hereditary neoplastic syndrome
p.Arg836= Multiple submitters lung cancer
p.Asn808= Multiple submitters lung cancer
p.Asn842= Multiple submitters lung cancer
p.Asp171= Multiple submitters hereditary neoplastic syndrome
p.Asp807= Multiple submitters lung cancer
p.Asp916= Multiple submitters lung cancer
p.Cys307= Multiple submitters hereditary neoplastic syndrome
p.Cys797= Multiple submitters lung cancer
p.Glu1005= Multiple submitters hereditary neoplastic syndrome
p.Glu711= Multiple submitters hereditary neoplastic syndrome
p.Glu749= Multiple submitters hereditary neoplastic syndrome
p.Glu804= Multiple submitters hereditary neoplastic syndrome
p.Glu829= Multiple submitters lung cancer
p.Gly1189Ala Multiple submitters hereditary neoplastic syndrome
p.Gly305= Multiple submitters EGFR-related lung cancer
p.Gly343= Multiple submitters EGFR-related lung cancer
p.Gly503= Multiple submitters EGFR-related lung cancer
p.Gly544= Multiple submitters hereditary neoplastic syndrome
p.Gly696= Multiple submitters lung cancer
p.Gly721= Multiple submitters EGFR-related lung cancer
p.Gly729= Multiple submitters hereditary neoplastic syndrome
p.His304= Multiple submitters EGFR-related lung cancer
p.His773= Multiple submitters hereditary neoplastic syndrome
p.His850= Multiple submitters lung cancer
p.His870= Multiple submitters EGFR-related lung cancer
p.His988Pro Multiple submitters lung cancer
p.Ile809= Multiple submitters EGFR-related lung cancer
p.Ile821= Multiple submitters lung cancer
p.Ile821= Multiple submitters lung cancer
p.Ile926Asn Multiple submitters hereditary neoplastic syndrome
p.Leu1198= Multiple submitters EGFR-related lung cancer
p.Leu349= Multiple submitters EGFR-related lung cancer
p.Leu480= Multiple submitters EGFR-related lung cancer
p.Leu707= Multiple submitters lung cancer
p.Leu760= Multiple submitters hereditary neoplastic syndrome
p.Leu777= Multiple submitters hereditary neoplastic syndrome
p.Leu778= Multiple submitters lung cancer
p.Leu782= Multiple submitters lung cancer
p.Leu788= Multiple submitters lung cancer
p.Leu798= Multiple submitters lung cancer
p.Leu799= Multiple submitters lung cancer
p.Leu828= Multiple submitters lung cancer
p.Leu861= Multiple submitters EGFR-related lung cancer
p.Lys757= Multiple submitters lung cancer
p.Lys852= Multiple submitters lung cancer
p.Phe723= Multiple submitters lung cancer
p.Phe795= Multiple submitters EGFR-related lung cancer
p.Phe856= Multiple submitters EGFR-related lung cancer
p.Pro691= Multiple submitters lung cancer
p.Pro741= Multiple submitters EGFR-related lung cancer
p.Pro753= Multiple submitters hereditary neoplastic syndrome
p.Pro848= Multiple submitters lung cancer
p.Ser1070= Multiple submitters EGFR-related lung cancer
p.Ser1162Asn Multiple submitters lung cancer
p.Ser720= Multiple submitters hereditary neoplastic syndrome
p.Ser768= Multiple submitters hereditary neoplastic syndrome
p.Ser885= Multiple submitters hereditary neoplastic syndrome
p.Thr211= Multiple submitters EGFR-related lung cancer
p.Thr693= Multiple submitters lung cancer
p.Thr710= Multiple submitters lung cancer
p.Thr725= Multiple submitters lung cancer
p.Thr783= Multiple submitters hereditary neoplastic syndrome
p.Thr785= Multiple submitters EGFR-related lung cancer
p.Thr790= Multiple submitters lung cancer
p.Tyr610= Multiple submitters hereditary neoplastic syndrome
p.Tyr626= Multiple submitters hereditary neoplastic syndrome
p.Tyr74= Multiple submitters EGFR-related lung cancer
p.Tyr764= Multiple submitters hereditary neoplastic syndrome
p.Tyr869= Multiple submitters lung cancer
p.Tyr900= Multiple submitters hereditary neoplastic syndrome
p.Val1047Met Multiple submitters hereditary neoplastic syndrome
p.Val592Ile Multiple submitters EGFR-related lung cancer ⚠
p.Val726= Multiple submitters lung cancer
p.Val742= Multiple submitters hereditary neoplastic syndrome
p.Val769= Multiple submitters lung cancer
p.Val786= Multiple submitters lung cancer
p.Val819= Multiple submitters lung cancer
p.Val845= Multiple submitters lung cancer
p.Val851= Multiple submitters lung cancer

Likely benign 1317

Showing the top 300 by review status; the full set is in the sitemap.

c.1499-4G>A Multiple submitters EGFR-related lung cancer
c.1631+133G>A Multiple submitters
c.1881-2611A>C Multiple submitters
c.1881-615G>A Multiple submitters
c.1881-726C>G Multiple submitters
c.1881-891T>C Multiple submitters
c.1919+134T>G Multiple submitters
c.1919+174G>A Multiple submitters
c.1920-4C>T Multiple submitters EGFR-related lung cancer
c.2061+65G>A Multiple submitters
c.2062-17_2062-16del Multiple submitters lung cancer
c.2062-4C>G Multiple submitters hereditary neoplastic syndrome
c.2062-7C>G Multiple submitters lung cancer
c.2062-7C>T Multiple submitters EGFR-related lung cancer
c.2062-8C>T Multiple submitters lung cancer
c.2184+154A>G Multiple submitters
c.2184+8C>G Multiple submitters lung cancer
c.2184+8C>T Multiple submitters lung cancer
c.2185-13C>T Multiple submitters EGFR-related lung cancer
c.2185-20T>C Multiple submitters lung cancer
c.2185-4A>G Multiple submitters lung cancer
c.2283+69G>A Multiple submitters
c.2283+8T>G Multiple submitters lung cancer
c.2284-10C>T Multiple submitters EGFR-related lung cancer
c.2284-16C>T Multiple submitters lung cancer
c.2284-18G>A Multiple submitters lung cancer
c.2284-20G>C Multiple submitters lung cancer
c.2284-20G>T Multiple submitters EGFR-related lung cancer
c.241-4T>C Multiple submitters EGFR-related lung cancer
c.2470-14C>T Multiple submitters EGFR-related lung cancer
c.2470-15T>C Multiple submitters lung cancer
c.2470-16G>T Multiple submitters lung cancer
c.2470-17G>C Multiple submitters EGFR-related lung cancer
c.2625+8G>T Multiple submitters EGFR-related lung cancer
c.2625+9G>A Multiple submitters lung cancer
c.2849-165C>T Multiple submitters
c.2946+20C>T Multiple submitters EGFR-related lung cancer
c.2946+240C>G Multiple submitters
c.2947-4C>T Multiple submitters hereditary neoplastic syndrome
c.3114+90C>T Multiple submitters
c.3115-180G>T Multiple submitters
c.425-4G>A Multiple submitters hereditary neoplastic syndrome
c.560-184T>A Multiple submitters
c.629-330G>T Multiple submitters
c.629-4T>C Multiple submitters hereditary neoplastic syndrome
c.748-4A>G Multiple submitters hereditary neoplastic syndrome
c.890-4C>T Multiple submitters hereditary neoplastic syndrome
c.*78C>T Multiple submitters
p.Ala10= Multiple submitters hereditary neoplastic syndrome
p.Ala1013= Multiple submitters hereditary neoplastic syndrome
p.Ala1118= Multiple submitters hereditary neoplastic syndrome
p.Ala1158= Multiple submitters hereditary neoplastic syndrome
p.Ala118= Multiple submitters EGFR-related lung cancer
p.Ala1181= Multiple submitters EGFR-related lung cancer
p.Ala1201= Multiple submitters EGFR-related lung cancer
p.Ala1210= Multiple submitters EGFR-related lung cancer
p.Ala13= Multiple submitters hereditary neoplastic syndrome
p.Ala155= Multiple submitters hereditary neoplastic syndrome
p.Ala17= Multiple submitters hereditary neoplastic syndrome
p.Ala202= Multiple submitters hereditary neoplastic syndrome
p.Ala21= Multiple submitters EGFR-related lung cancer
p.Ala24= Multiple submitters EGFR-related lung cancer
p.Ala258= Multiple submitters hereditary neoplastic syndrome
p.Ala313= Multiple submitters hereditary neoplastic syndrome
p.Ala375= Multiple submitters hereditary neoplastic syndrome
p.Ala501= Multiple submitters hereditary neoplastic syndrome
p.Ala613= Multiple submitters hereditary neoplastic syndrome
p.Ala7= Multiple submitters hereditary neoplastic syndrome
p.Ala722= Multiple submitters EGFR-related lung cancer
p.Ala750= Multiple submitters hereditary neoplastic syndrome
p.Ala767= Multiple submitters EGFR-related lung cancer
p.Ala9= Multiple submitters hereditary neoplastic syndrome
p.Ala92= Multiple submitters hereditary neoplastic syndrome
p.Arg108= Multiple submitters hereditary neoplastic syndrome
p.Arg1100= Multiple submitters hereditary neoplastic syndrome
p.Arg23= Multiple submitters hereditary neoplastic syndrome
p.Arg244= Multiple submitters hereditary neoplastic syndrome
p.Arg334= Multiple submitters hereditary neoplastic syndrome
p.Arg427= Multiple submitters hereditary neoplastic syndrome
p.Arg521= Multiple submitters hereditary neoplastic syndrome
p.Arg670= Multiple submitters EGFR-related lung cancer
p.Arg675= Multiple submitters hereditary neoplastic syndrome
p.Arg681= Multiple submitters hereditary neoplastic syndrome
p.Arg686= Multiple submitters hereditary neoplastic syndrome
p.Arg832= Multiple submitters hereditary neoplastic syndrome
p.Arg841= Multiple submitters hereditary neoplastic syndrome
p.Arg958= Multiple submitters hereditary neoplastic syndrome
p.Arg986= Multiple submitters hereditary neoplastic syndrome
p.Arg999= Multiple submitters hereditary neoplastic syndrome
p.Asn1107= Multiple submitters hereditary neoplastic syndrome
p.Asn1116= Multiple submitters hereditary neoplastic syndrome
p.Asn124= Multiple submitters hereditary neoplastic syndrome
p.Asn175= Multiple submitters hereditary neoplastic syndrome
p.Asn234= Multiple submitters hereditary neoplastic syndrome
p.Asn280= Multiple submitters EGFR-related lung cancer
p.Asn338= Multiple submitters hereditary neoplastic syndrome
p.Asn444= Multiple submitters EGFR-related lung cancer
p.Asn497= Multiple submitters EGFR-related lung cancer
p.Asn528= Multiple submitters EGFR-related lung cancer
p.Asn552= Multiple submitters EGFR-related lung cancer
p.Asn604= Multiple submitters hereditary neoplastic syndrome
p.Asn639= Multiple submitters hereditary neoplastic syndrome
p.Asn64= Multiple submitters EGFR-related lung cancer
p.Asn94= Multiple submitters hereditary neoplastic syndrome
p.Asn996= Multiple submitters EGFR-related lung cancer
p.Asp1008= Multiple submitters EGFR-related lung cancer
p.Asp1009= Multiple submitters EGFR-related lung cancer
p.Asp1014= Multiple submitters EGFR-related lung cancer
p.Asp1051= Multiple submitters hereditary neoplastic syndrome
p.Asp1083= Multiple submitters hereditary neoplastic syndrome
p.Asp1084= Multiple submitters hereditary neoplastic syndrome
p.Asp1122= Multiple submitters EGFR-related lung cancer
p.Asp126= Multiple submitters hereditary neoplastic syndrome
p.Asp256= Multiple submitters hereditary neoplastic syndrome
p.Asp262= Multiple submitters EGFR-related lung cancer
p.Asp278= Multiple submitters hereditary neoplastic syndrome
p.Asp321= Multiple submitters EGFR-related lung cancer
p.Asp347= Multiple submitters EGFR-related lung cancer
p.Asp379= Multiple submitters EGFR-related lung cancer
p.Asp458= Multiple submitters EGFR-related lung cancer
p.Asp46= Multiple submitters hereditary neoplastic syndrome
p.Asp522= Multiple submitters EGFR-related lung cancer
p.Asp587= Multiple submitters hereditary neoplastic syndrome
p.Asp612= Multiple submitters hereditary neoplastic syndrome
p.Asp837= Multiple submitters EGFR-related lung cancer
p.Asp896= Multiple submitters EGFR-related lung cancer
p.Asp942= Multiple submitters EGFR-related lung cancer
p.Asp954= Multiple submitters hereditary neoplastic syndrome
p.Cys1058= Multiple submitters hereditary neoplastic syndrome
p.Cys187= Multiple submitters EGFR-related lung cancer
p.Cys219= Multiple submitters hereditary neoplastic syndrome
p.Cys251= Multiple submitters hereditary neoplastic syndrome
p.Cys260= Multiple submitters hereditary neoplastic syndrome
p.Cys264= Multiple submitters hereditary neoplastic syndrome
p.Cys291= Multiple submitters EGFR-related lung cancer
p.Cys295= Multiple submitters EGFR-related lung cancer
p.Cys31= Multiple submitters hereditary neoplastic syndrome
p.Cys510= Multiple submitters hereditary neoplastic syndrome
p.Cys523= Multiple submitters EGFR-related lung cancer
p.Cys558= Multiple submitters hereditary neoplastic syndrome
p.Cys58= Multiple submitters hereditary neoplastic syndrome
p.Cys582= Multiple submitters EGFR-related lung cancer
p.Cys591= Multiple submitters hereditary neoplastic syndrome
p.Cys595= Multiple submitters hereditary neoplastic syndrome
p.Cys617= Multiple submitters hereditary neoplastic syndrome
p.Cys624= Multiple submitters hereditary neoplastic syndrome
p.Gln1020= Multiple submitters EGFR-related lung cancer
p.Gln105= Multiple submitters hereditary neoplastic syndrome
p.Gln1159= Multiple submitters EGFR-related lung cancer
p.Gln1174= Multiple submitters hereditary neoplastic syndrome
p.Gln1203= Multiple submitters EGFR-related lung cancer
p.Gln208= Multiple submitters EGFR-related lung cancer
p.Gln276= Multiple submitters EGFR-related lung cancer
p.Gln432= Multiple submitters EGFR-related lung cancer
p.Gln486= Multiple submitters hereditary neoplastic syndrome
p.Gln52= Multiple submitters hereditary neoplastic syndrome
p.Gln557= Multiple submitters hereditary neoplastic syndrome
p.Gln581= Multiple submitters EGFR-related lung cancer
p.Gln71= Multiple submitters hereditary neoplastic syndrome
p.Gln83= Multiple submitters hereditary neoplastic syndrome
p.Glu1015= Multiple submitters EGFR-related lung cancer
p.Glu1079= Multiple submitters hereditary neoplastic syndrome
p.Glu205= Multiple submitters EGFR-related lung cancer
p.Glu320= Multiple submitters hereditary neoplastic syndrome
p.Glu400= Multiple submitters hereditary neoplastic syndrome
p.Glu455= Multiple submitters EGFR-related lung cancer
p.Glu513= Multiple submitters hereditary neoplastic syndrome
p.Glu534= Multiple submitters hereditary neoplastic syndrome
p.Glu545= Multiple submitters EGFR-related lung cancer
p.Glu548= Multiple submitters EGFR-related lung cancer
p.Glu554= Multiple submitters hereditary neoplastic syndrome
p.Glu59= Multiple submitters EGFR-related lung cancer
p.Glu685= Multiple submitters EGFR-related lung cancer
p.Glu84= Multiple submitters EGFR-related lung cancer
p.Glu865= Multiple submitters hereditary neoplastic syndrome
p.Glu868= Multiple submitters hereditary neoplastic syndrome
p.Gly1075= Multiple submitters hereditary neoplastic syndrome
p.Gly1103= Multiple submitters hereditary neoplastic syndrome
p.Gly197= Multiple submitters hereditary neoplastic syndrome
p.Gly221= Multiple submitters hereditary neoplastic syndrome
p.Gly242= Multiple submitters hereditary neoplastic syndrome
p.Gly312= Multiple submitters hereditary neoplastic syndrome
p.Gly322= Multiple submitters hereditary neoplastic syndrome
p.Gly367= Multiple submitters hereditary neoplastic syndrome
p.Gly403= Multiple submitters EGFR-related lung cancer
p.Gly434= Multiple submitters EGFR-related lung cancer
p.Gly465= Multiple submitters EGFR-related lung cancer
p.Gly482= Multiple submitters hereditary neoplastic syndrome
p.Gly5= Multiple submitters EGFR-related lung cancer
p.Gly588= Multiple submitters EGFR-related lung cancer
p.Gly598= Multiple submitters hereditary neoplastic syndrome
p.Gly635= Multiple submitters EGFR-related lung cancer
p.Gly665= Multiple submitters hereditary neoplastic syndrome
p.Gly719= Multiple submitters EGFR-related lung cancer
p.Gly735= Multiple submitters EGFR-related lung cancer
p.His1156= Multiple submitters EGFR-related lung cancer
p.His145= Multiple submitters EGFR-related lung cancer
p.His233= Multiple submitters hereditary neoplastic syndrome
p.His418= Multiple submitters EGFR-related lung cancer
p.His590= Multiple submitters hereditary neoplastic syndrome
p.Ile1018= Multiple submitters hereditary neoplastic syndrome
p.Ile143= Multiple submitters hereditary neoplastic syndrome
p.Ile213= Multiple submitters EGFR-related lung cancer
p.Ile401= Multiple submitters EGFR-related lung cancer
p.Ile425= Multiple submitters hereditary neoplastic syndrome
p.Ile646= Multiple submitters hereditary neoplastic syndrome
p.Ile664= Multiple submitters hereditary neoplastic syndrome
p.Ile673= Multiple submitters hereditary neoplastic syndrome
p.Ile82= Multiple submitters hereditary neoplastic syndrome
p.Ile853= Multiple submitters hereditary neoplastic syndrome
p.Ile918= Multiple submitters EGFR-related lung cancer
p.Ile941= Multiple submitters hereditary neoplastic syndrome
p.Ile946= Multiple submitters hereditary neoplastic syndrome
p.Ile966= Multiple submitters hereditary neoplastic syndrome
p.Leu1001= Multiple submitters EGFR-related lung cancer
p.Leu1017= Multiple submitters hereditary neoplastic syndrome
p.Leu1034= Multiple submitters hereditary neoplastic syndrome
p.Leu1066= Multiple submitters hereditary neoplastic syndrome
p.Leu1077= Multiple submitters hereditary neoplastic syndrome
p.Leu11= Multiple submitters hereditary neoplastic syndrome
p.Leu1139= Multiple submitters EGFR-related lung cancer
p.Leu12= Multiple submitters hereditary neoplastic syndrome
p.Leu132= Multiple submitters EGFR-related lung cancer
p.Leu144= Multiple submitters EGFR-related lung cancer
p.Leu15= Multiple submitters hereditary neoplastic syndrome
p.Leu156= Multiple submitters EGFR-related lung cancer
p.Leu173= Multiple submitters EGFR-related lung cancer
p.Leu25= Multiple submitters hereditary neoplastic syndrome
p.Leu269= Multiple submitters hereditary neoplastic syndrome
p.Leu372= Multiple submitters hereditary neoplastic syndrome
p.Leu38= Multiple submitters hereditary neoplastic syndrome
p.Leu392= Multiple submitters hereditary neoplastic syndrome
p.Leu405= Multiple submitters EGFR-related lung cancer
p.Leu417= Multiple submitters EGFR-related lung cancer
p.Leu423= Multiple submitters EGFR-related lung cancer
p.Leu51= Multiple submitters hereditary neoplastic syndrome
p.Leu541= Multiple submitters hereditary neoplastic syndrome
p.Leu606= Multiple submitters hereditary neoplastic syndrome
p.Leu655= Multiple submitters hereditary neoplastic syndrome
p.Leu662= Multiple submitters hereditary neoplastic syndrome
p.Leu703= Multiple submitters hereditary neoplastic syndrome
p.Leu76= Multiple submitters hereditary neoplastic syndrome
p.Leu814= Multiple submitters EGFR-related lung cancer
p.Leu814= Multiple submitters hereditary neoplastic syndrome
p.Leu838= Multiple submitters hereditary neoplastic syndrome
p.Leu883= Multiple submitters hereditary neoplastic syndrome
p.Leu927= Multiple submitters EGFR-related lung cancer
p.Leu964= Multiple submitters EGFR-related lung cancer
p.Leu979= Multiple submitters EGFR-related lung cancer
p.Lys1160= Multiple submitters hereditary neoplastic syndrome
p.Lys261= Multiple submitters hereditary neoplastic syndrome
p.Lys293= Multiple submitters EGFR-related lung cancer
p.Lys294= Multiple submitters hereditary neoplastic syndrome
p.Lys37= Multiple submitters hereditary neoplastic syndrome
p.Lys478= Multiple submitters hereditary neoplastic syndrome
p.Lys500= Multiple submitters hereditary neoplastic syndrome
p.Lys593= Multiple submitters hereditary neoplastic syndrome
p.Lys708= Multiple submitters EGFR-related lung cancer
p.Phe1151= Multiple submitters EGFR-related lung cancer
p.Phe287= Multiple submitters EGFR-related lung cancer
p.Phe376= Multiple submitters hereditary neoplastic syndrome
p.Phe420= Multiple submitters hereditary neoplastic syndrome
p.Phe481= Multiple submitters hereditary neoplastic syndrome
p.Pro1027= Multiple submitters hereditary neoplastic syndrome
p.Pro1033= Multiple submitters hereditary neoplastic syndrome
p.Pro1059= Multiple submitters hereditary neoplastic syndrome
p.Pro1101= Multiple submitters hereditary neoplastic syndrome
p.Pro1114= Multiple submitters hereditary neoplastic syndrome
p.Pro1117= Multiple submitters hereditary neoplastic syndrome
p.Pro1136= Multiple submitters hereditary neoplastic syndrome
p.Pro154= Multiple submitters EGFR-related lung cancer
p.Pro20= Multiple submitters EGFR-related lung cancer
p.Pro272= Multiple submitters EGFR-related lung cancer
p.Pro3= Multiple submitters EGFR-related lung cancer
p.Pro389= Multiple submitters EGFR-related lung cancer
p.Pro546= Multiple submitters hereditary neoplastic syndrome
p.Pro576= Multiple submitters hereditary neoplastic syndrome
p.Pro589= Multiple submitters hereditary neoplastic syndrome
p.Pro596= Multiple submitters hereditary neoplastic syndrome
p.Pro637= Multiple submitters hereditary neoplastic syndrome
p.Pro959= Multiple submitters hereditary neoplastic syndrome
p.Pro975= Multiple submitters hereditary neoplastic syndrome
p.Ser1028= Multiple submitters EGFR-related lung cancer
p.Ser1042= Multiple submitters hereditary neoplastic syndrome
p.Ser1081= Multiple submitters hereditary neoplastic syndrome
p.Ser1130= Multiple submitters EGFR-related lung cancer
p.Ser1204= Multiple submitters hereditary neoplastic syndrome
p.Ser177= Multiple submitters hereditary neoplastic syndrome
p.Ser198= Multiple submitters hereditary neoplastic syndrome
p.Ser220= Multiple submitters hereditary neoplastic syndrome
p.Ser227= Multiple submitters hereditary neoplastic syndrome
p.Ser246= Multiple submitters hereditary neoplastic syndrome
p.Ser286= Multiple submitters hereditary neoplastic syndrome
p.Ser348= Multiple submitters hereditary neoplastic syndrome
p.Ser4= Multiple submitters EGFR-related lung cancer
p.Ser457= Multiple submitters hereditary neoplastic syndrome
p.Ser484= Multiple submitters hereditary neoplastic syndrome
p.Ser553= Multiple submitters hereditary neoplastic syndrome
p.Ser899= Multiple submitters hereditary neoplastic syndrome
p.Ser921= Multiple submitters hereditary neoplastic syndrome

Uncertain significance 1766

Showing the top 300 by review status; the full set is in the sitemap.

c.1207+5G>A Multiple submitters hereditary neoplastic syndrome
c.1298+3A>G Multiple submitters hereditary neoplastic syndrome
c.1298+4A>G Multiple submitters hereditary neoplastic syndrome
c.1298+6T>C Multiple submitters hereditary neoplastic syndrome
c.1499-3C>T Multiple submitters EGFR-related lung cancer
c.1499-4G>T Multiple submitters hereditary neoplastic syndrome
c.1920-3C>T Multiple submitters hereditary neoplastic syndrome
c.2061+3G>A Multiple submitters hereditary neoplastic syndrome
c.2061+5G>A Multiple submitters EGFR-related lung cancer
c.2062-3C>A Multiple submitters hereditary neoplastic syndrome
c.2062-3C>G Multiple submitters EGFR-related lung cancer
c.2184+4A>G Multiple submitters hereditary neoplastic syndrome
c.2283+1G>A Multiple submitters hereditary neoplastic syndrome
c.2469+5T>C Multiple submitters hereditary neoplastic syndrome
c.2849-3C>T Multiple submitters hereditary neoplastic syndrome
c.2946+3A>G Multiple submitters hereditary neoplastic syndrome
c.2946+5A>G Multiple submitters hereditary neoplastic syndrome
c.3114+3A>G Multiple submitters hereditary neoplastic syndrome
c.3114+4T>G Multiple submitters EGFR-related lung cancer
c.3271+3G>A Multiple submitters EGFR-related lung cancer
c.3271+49del Multiple submitters lung cancer
c.628+2dup Multiple submitters hereditary neoplastic syndrome
c.629-3C>T Multiple submitters EGFR-related lung cancer
c.748-3T>C Multiple submitters EGFR-related lung cancer
c.889+3G>A Multiple submitters hereditary neoplastic syndrome
p.Ala1040Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1076Leu Multiple submitters hereditary neoplastic syndrome
p.Ala1076Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1076Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala10Glu Multiple submitters EGFR-related lung cancer ⚠
p.Ala118Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala118Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1192Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1192Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1201Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala1201Val Multiple submitters EGFR-related lung cancer ⚠
p.Ala120Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala13Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala147Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala147Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala21_Ser22insArgAla Multiple submitters hereditary neoplastic syndrome
p.Ala21Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala238Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala310Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala310Val Multiple submitters EGFR-related lung cancer ⚠
p.Ala472Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala501Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala508Gly Multiple submitters EGFR-related lung cancer ⚠
p.Ala597Ser Multiple submitters EGFR-related lung cancer ⚠
p.Ala611Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala647Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala647Thr Multiple submitters EGFR-related lung cancer ⚠
p.Ala702Gly Multiple submitters EGFR-related lung cancer ⚠
p.Ala743Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala763Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala767Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala767Val Multiple submitters EGFR-related lung cancer ⚠
p.Ala7Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala7Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala822Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala822Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala864Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala864Val Multiple submitters EGFR-related lung cancer ⚠
p.Ala955Thr Multiple submitters EGFR-related lung cancer ⚠
p.Ala972Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala972Thr Multiple submitters EGFR-related lung cancer ⚠
p.Arg1031Gln Multiple submitters lung cancer ⚠
p.Arg1031Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg1068Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg1068Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg1100Ser Multiple submitters EGFR-related lung cancer ⚠
p.Arg1121Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg138Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg149Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg149Trp Multiple submitters EGFR-related lung cancer ⚠
p.Arg165Leu Multiple submitters EGFR-related lung cancer ⚠
p.Arg165Trp Multiple submitters inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Arg222His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg222Ser Multiple submitters EGFR-related lung cancer ⚠
p.Arg224Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg224His Multiple submitters EGFR-related lung cancer ⚠
p.Arg23Pro Multiple submitters EGFR-related lung cancer ⚠
p.Arg244Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg244Gly Multiple submitters EGFR-related lung cancer ⚠
p.Arg244Trp Multiple submitters EGFR-related lung cancer ⚠
p.Arg252Cys Multiple submitters EGFR-related lung cancer ⚠
p.Arg252His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg255Gln Multiple submitters EGFR-related lung cancer ⚠
p.Arg324His Multiple submitters EGFR-related lung cancer ⚠
p.Arg324Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg334Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg427Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg451Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg451His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg521Asn Multiple submitters hereditary neoplastic syndrome
p.Arg527Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg531Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg53Lys Multiple submitters EGFR-related lung cancer ⚠
p.Arg547Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg574Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg669Gln Multiple submitters EGFR-related lung cancer ⚠
p.Arg671Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg671His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg677Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg677His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg680Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg680Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg705Lys Multiple submitters EGFR-related lung cancer ⚠
p.Arg705Ser Multiple submitters EGFR-related lung cancer ⚠
p.Arg776Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg803Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg803Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg831Cys Multiple submitters inflammatory skin and bowel disease, neonatal, 2 ⚠
p.Arg832Cys Multiple submitters EGFR-related lung cancer ⚠
p.Arg832His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg836His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg932Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg958Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg958His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg962Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg962Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg973Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg973Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg977Cys Multiple submitters EGFR-related lung cancer ⚠
p.Arg977His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg977Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg999Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg999His Multiple submitters lung cancer ⚠
p.Arg999Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn1043Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn1107Ser Multiple submitters lung carcinoma ⚠
p.Asn1112His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn1135Tyr Multiple submitters EGFR-related lung cancer ⚠
p.Asn1148Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn1169Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn139Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn152Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn158Lys Multiple submitters EGFR-related lung cancer ⚠
p.Asn196Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn234Lys Multiple submitters EGFR-related lung cancer ⚠
p.Asn413Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn444His Multiple submitters EGFR-related lung cancer ⚠
p.Asn540Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn623Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn639Asp Multiple submitters EGFR-related lung cancer ⚠
p.Asn639Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn700Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn73Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn808Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn996Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1006Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1006His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1008Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1009Asn Multiple submitters EGFR-related lung cancer ⚠
p.Asp1012His Multiple submitters lung cancer ⚠
p.Asp1014Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1051Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1063Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1072Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1072Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1072Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1080Gly Multiple submitters EGFR-related lung cancer ⚠
p.Asp1083Glu Multiple submitters EGFR-related lung cancer ⚠
p.Asp1084Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1084Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1122Glu Multiple submitters EGFR-related lung cancer ⚠
p.Asp1152Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1152His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp1175Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp191Glu Multiple submitters EGFR-related lung cancer ⚠
p.Asp256Glu Multiple submitters EGFR-related lung cancer ⚠
p.Asp314Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp321Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp46Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp46Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp522Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp612Gly Multiple submitters EGFR-related lung cancer ⚠
p.Asp75Ala Multiple submitters EGFR-related lung cancer ⚠
p.Asp761Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp761His Multiple submitters EGFR-related lung cancer ⚠
p.Asp807Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp916Asn Multiple submitters EGFR-related lung cancer ⚠
p.Asp942Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp942His Multiple submitters EGFR-related lung cancer ⚠
p.Asp956Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp974Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp974Glu Multiple submitters EGFR-related lung cancer ⚠
p.Asp994Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys1146Phe Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys1146Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys236Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys591Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys775Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln1020His Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln1056His Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln105His Multiple submitters EGFR-related lung cancer ⚠
p.Gln1067Lys Multiple submitters EGFR-related lung cancer ⚠
p.Gln1106Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln1143His Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln1143Pro Multiple submitters EGFR-related lung cancer ⚠
p.Gln1159Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln1173Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln188Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln276Arg Multiple submitters EGFR-related lung cancer ⚠
p.Gln408Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln40Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln557Arg Multiple submitters EGFR-related lung cancer ⚠
p.Gln565Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln684Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln684Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln701Lys Multiple submitters EGFR-related lung cancer ⚠
p.Gln71Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln791His Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln894His Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln976Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln982Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1004Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1005del Multiple submitters hereditary neoplastic syndrome
p.Glu1015Lys Multiple submitters EGFR-related lung cancer ⚠
p.Glu1079Asp Multiple submitters EGFR-related lung cancer ⚠
p.Glu1091Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1137Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1137Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu114Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1180Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu1193Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu205Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu245Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu319Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu344Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu412Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu513Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu519Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu545Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu551Val Multiple submitters EGFR-related lung cancer ⚠
p.Glu554Gly Multiple submitters EGFR-related lung cancer ⚠
p.Glu59Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu634Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu685Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu687= Multiple submitters hereditary neoplastic syndrome
p.Glu709Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu758Asp Multiple submitters EGFR-related lung cancer ⚠
p.Glu804Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu829Gln Multiple submitters EGFR-related lung cancer ⚠
p.Glu84Asp Multiple submitters EGFR-related lung cancer ⚠
p.Glu84Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu865Lys Multiple submitters EGFR-related lung cancer ⚠
p.Glu866Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu922Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu922Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu928Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu963Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu967Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1022Asp Multiple submitters EGFR-related lung cancer ⚠
p.Gly1054= Multiple submitters hereditary neoplastic syndrome
p.Gly1075Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1075Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1075Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly109Ala Multiple submitters EGFR-related lung cancer ⚠
p.Gly1103Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly1161Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1161Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1185Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1189Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly1209Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly221Glu Multiple submitters EGFR-related lung cancer ⚠
p.Gly225= Multiple submitters hereditary neoplastic syndrome
p.Gly239Ala Multiple submitters EGFR-related lung cancer ⚠
p.Gly288Asp Multiple submitters EGFR-related lung cancer ⚠
p.Gly305Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly322Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly343Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly42Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly434Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly485Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly485Cys Multiple submitters EGFR-related lung cancer ⚠
p.Gly503Asp Multiple submitters EGFR-related lung cancer ⚠
p.Gly503Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly517Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly544Asp Multiple submitters EGFR-related lung cancer ⚠
p.Gly544Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly575Glu Multiple submitters EGFR-related lung cancer ⚠
p.Gly588Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly5Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly5Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly627Arg Multiple submitters EGFR-related lung cancer ⚠
p.Gly635Ser Multiple submitters EGFR-related lung cancer ⚠
p.Gly63Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly652Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly721Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly724Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly779Asp Multiple submitters EGFR-related lung cancer ⚠
p.Gly863Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly873Glu Multiple submitters EGFR-related lung cancer ⚠
p.Gly8Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly901Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly901Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly917Arg Multiple submitters EGFR-related lung cancer ⚠
p.Gly983Val Multiple submitters hereditary neoplastic syndrome ⚠
p.His1124Arg Multiple submitters EGFR-related lung cancer ⚠