Is FLT3 p.Arg973Gln (c.2918G>A) pathogenic?

FLT3 p.Arg973Gln (c.2918G>A) is classified Likely benign in FLT3 (ClinVar, Single submitter, 2 submitters; last evaluated 2018-02-26). AlphaMissense: likely benign (0.0672); Rare (popmax 0.689%, afr).

How common is FLT3 p.Arg973Gln (c.2918G>A) in the general population?

FLT3 p.Arg973Gln (c.2918G>A) is rare (popmax 0.689%, afr) (gnomAD).

What do computational predictors say about FLT3 p.Arg973Gln (c.2918G>A)?

AlphaMissense predicts likely benign (score 0.0672) — an in-silico prediction, not a clinical call.

FLT3 p.Arg973Gln

c.2918G>A · rs144397269 · VCV134440

Likely benign Single submitter

Classification

Likely benign

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 2 submitters

AlphaMissense

likely benign

0.0672 · ACMG-weighted

gnomAD v4.1

Rare

rare (popmax 0.689%, afr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0672	likely benign
REVEL	0.068	moderately benign-leaning
SaProt	LLR -6.23	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 0.22	GERP -2.8, phastCons 0.002
Regional constraint	o/e 0.90	unconstrained · MANE · 96 kb · p 0.00044 · regional, not allelic
Overall
CADD	6.107	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.689% African / African-American · 517/75,012 alleles

Filtering AF 0.64% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.621%

Overall 0.0351% 566/1,614,006 alleles · rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.689%	145
Admixed American	0.0367%	2,727
Remaining individualsnot grpmax-eligible	0.0304%	3,290
Middle Eastern	0.0166%	6,028
Ashkenazi Jewishnot grpmax-eligible	0.00338%	29,604
South Asian	0.0022%	45,535
European (non-Finnish)	0.000339%	295,000

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: FLT3
Protein: p.Arg973Gln
Coding: c.2918G>A
MANE Select: NM_004119
dbSNP: rs144397269
Type: single nucleotide variant
Location: chr13:28004116 (GRCh38)
Gene constraint: LOEUF 0.468 · pLI 1.00 (gnomAD)
Structure: AlphaFold pLDDT 76.19 · 11 PDB

Full FLT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

FLT3 c.1205+56C>T Benign ★★ same type
FLT3 c.1310-3T>C Benign ★★ same type
FLT3 c.1418+75A>G Benign ★★ same type
FLT3 c.1418+81A>G Benign ★★ same type
FLT3 c.1419-15T>C Benign ★★ same type
FLT3 c.1419-36T>A Benign ★★ same type
FLT3 c.1597+8A>G Likely benign ★★ same type
FLT3 c.165+118G>T Benign ★★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/flt3-p-arg973gln (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown