FLT3 — 214 ClinVar variants
All ClinVar germline FLT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
9 Pathogenic · 3 Likely pathogenic · 84 Benign · 40 Likely benign · 78 Uncertain significance
Full FLT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FLT3 p.Ala149Asp Uncertain significance Single submitter
- FLT3 p.Ala291Pro Uncertain significance Single submitter
- FLT3 p.Ala425Ser Uncertain significance Single submitter
- FLT3 p.Ala447Gly Uncertain significance Single submitter
- FLT3 p.Ala66Val Uncertain significance Single submitter
- FLT3 p.Arg68Gly Uncertain significance Single submitter
- FLT3 p.Arg961Cys Uncertain significance Single submitter
- FLT3 p.Asn434Ser Uncertain significance Single submitter
- FLT3 p.Asp540His Uncertain significance Single submitter
- FLT3 p.Cys828Arg Uncertain significance Single submitter
- FLT3 p.Cys965Tyr Uncertain significance Single submitter
- FLT3 p.Gln363Glu Uncertain significance Single submitter
- FLT3 p.Gln667Lys Uncertain significance Single submitter
- FLT3 p.Gln903Pro Uncertain significance Single submitter
- FLT3 p.Glu140Gln Uncertain significance Single submitter
- FLT3 p.Glu209Gly Uncertain significance Single submitter
- FLT3 p.Glu672Lys Uncertain significance Single submitter
- FLT3 p.Gly295Asp Uncertain significance Single submitter
- FLT3 p.Gly295Ser Uncertain significance Single submitter
- FLT3 p.Gly739Ala Uncertain significance Single submitter
- FLT3 p.Gly960Asp Uncertain significance Single submitter
- FLT3 p.His279Arg Uncertain significance Single submitter
- FLT3 p.His967Tyr Uncertain significance Single submitter
- FLT3 p.Ile674Thr Uncertain significance Single submitter
- FLT3 p.Ile881Thr Uncertain significance Single submitter
- FLT3 p.Leu164Pro Uncertain significance Single submitter
- FLT3 p.Leu983Val Uncertain significance Single submitter
- FLT3 p.Lys175Arg Uncertain significance Single submitter
- FLT3 p.Lys207Ile Uncertain significance Single submitter
- FLT3 p.Lys334Thr Uncertain significance Single submitter
- FLT3 p.Lys490Arg Uncertain significance Single submitter
- FLT3 p.Lys709Thr Uncertain significance Single submitter
- FLT3 p.Met128Val Uncertain significance Single submitter
- FLT3 p.Met430Ile Uncertain significance Single submitter
- FLT3 p.Met645Leu Uncertain significance Single submitter
- FLT3 p.Phe537Val Uncertain significance Single submitter
- FLT3 p.Phe906Leu Uncertain significance Single submitter
- FLT3 p.Pro413Ser Uncertain significance Single submitter
- FLT3 p.Pro937Arg Uncertain significance Single submitter
- FLT3 p.Ser356Asn Uncertain significance Single submitter
- FLT3 p.Ser976Arg Uncertain significance Single submitter
- FLT3 p.Trp872Cys Uncertain significance Single submitter
- FLT3 p.Tyr328Ser Uncertain significance Single submitter
- FLT3 p.Tyr457Asn Uncertain significance Single submitter
- FLT3 p.Val275Ile Uncertain significance Single submitter
- FLT3 p.Val512Ile Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- FLT3 p.Ala450Thr Uncertain significance Single submitter
- FLT3 p.Asn306His Uncertain significance Single submitter
- FLT3 p.Asn847Ser Uncertain significance Single submitter
- FLT3 p.Asp398Tyr Uncertain significance Single submitter
- FLT3 p.Asp62Gly Uncertain significance Single submitter
- FLT3 p.Asp779Val Uncertain significance Single submitter
- FLT3 p.Asp84Gly Uncertain significance Single submitter
- FLT3 p.Gln121Arg Uncertain significance Single submitter
- FLT3 p.Glu217Gly Uncertain significance Single submitter
- FLT3 p.Glu240Ala Uncertain significance Single submitter
- FLT3 p.Glu803Gly Uncertain significance Single submitter
- FLT3 p.Gly493Val Uncertain significance Single submitter
- FLT3 p.Ile361Thr Uncertain significance Single submitter
- FLT3 p.Ile38Asn Uncertain significance Single submitter
- FLT3 p.Leu257Trp Uncertain significance Single submitter
- FLT3 p.Lys263Glu Uncertain significance Single submitter
- FLT3 p.Lys429Thr Uncertain significance Single submitter
- FLT3 p.Lys513Asn Uncertain significance Single submitter
- FLT3 p.Lys565Glu Uncertain significance Single submitter
- FLT3 p.Phe156Leu Uncertain significance Single submitter
- FLT3 p.Phe281Leu Uncertain significance Single submitter
- FLT3 p.Pro116Arg Likely benign Single submitter
- FLT3 p.Ser461Phe Uncertain significance Single submitter
- FLT3 p.Ser504Arg Uncertain significance Single submitter
- FLT3 p.Ser806Leu Uncertain significance Single submitter
- FLT3 p.Ser941Leu Uncertain significance Single submitter
- FLT3 p.Thr382Ala Uncertain significance Single submitter
- FLT3 p.Thr475Pro Likely benign Single submitter
- FLT3 p.Thr90Ala Uncertain significance Single submitter
-
FLT3 p.Tyr572Cys
Likely pathogenic
Single submitter
acute myeloid leukemia
- FLT3 p.Tyr919Cys Uncertain significance Single submitter
- FLT3 p.Val125Gly Uncertain significance Single submitter
- FLT3 p.Val317Glu Uncertain significance Single submitter
- FLT3 p.Val871Ile Uncertain significance Single submitter
- FLT3 p.Val894Ala Uncertain significance Single submitter
-
FLT3 p.Asp835Asn
Pathogenic
No assertion criteria
acute myeloid leukemia
-
FLT3 p.Asp835Glu
Pathogenic
No assertion criteria
acute myeloid leukemia
-
FLT3 p.Asp835His
Pathogenic
No assertion criteria
acute myeloid leukemia
-
FLT3 p.Ser446Leu
Likely benign
No assertion criteria
FLT3-related disorder
All FLT3 variants
Pathogenic 9
- p.Tyr597_Glu598insAspValAspPheArgGluTyr Single submitter Myelodysplastic syndrome progressed to acute myeloid leukemia
- p.Asp593del No assertion criteria acute lymphoblastic leukemia
- p.Asp835Asn No assertion criteria acute myeloid leukemia ⚠
- p.Asp835del No assertion criteria acute myeloid leukemia
- p.Asp835Glu No assertion criteria acute myeloid leukemia ⚠
- p.Asp835His No assertion criteria acute myeloid leukemia ⚠
- p.Asp835Tyr No assertion criteria acute myeloid leukemia
- p.Asp835Val No assertion criteria acute lymphoblastic leukemia
- p.Ser840_Asn841insGlySer No assertion criteria acute myeloid leukemia
Likely pathogenic 3
- p.Arg845Gly Single submitter acute myeloid leukemia
- p.Tyr572Cys Single submitter acute myeloid leukemia ⚠
- p.Tyr572His No assertion criteria plasma cell myeloma
Benign 84
- c.1205+56C>T Multiple submitters
- c.1310-3T>C Multiple submitters
- c.1418+75A>G Multiple submitters
- c.1418+81A>G Multiple submitters
- c.1419-15T>C Multiple submitters
- c.1419-36T>A Multiple submitters
- c.165+118G>T Multiple submitters
- c.1942+108A>T Multiple submitters
- c.1942+35A>C Multiple submitters
- c.2053+23A>G Multiple submitters
- c.2053+59G>A Multiple submitters
- c.2419-187G>A Multiple submitters
- c.2541+58A>G Multiple submitters
- c.2653+65G>C Multiple submitters
- c.2654-102G>C Multiple submitters
- c.2654-116G>A Multiple submitters
- c.2753+27G>A Multiple submitters
- c.44-81T>C Multiple submitters
- c.484+81C>T Multiple submitters
- c.484+8C>T Multiple submitters
- c.615-15C>A Multiple submitters
- c.615-72G>A Multiple submitters
- c.882+13G>A Multiple submitters
- c.883-25C>A Multiple submitters
- p.Ala988Pro Multiple submitters
- p.Asp7Gly Multiple submitters
- p.Asp96= Multiple submitters
- p.Gln426= Multiple submitters
- p.Ile417Leu Multiple submitters
- p.Leu561= Multiple submitters
- p.Phe605= Multiple submitters
- p.Pro986= Multiple submitters
- p.Ser993= Multiple submitters
- p.Thr227Met Multiple submitters
- p.Thr526= Multiple submitters
- p.Tyr591= Multiple submitters
- p.Val194Met Multiple submitters
- p.Val32= Multiple submitters
- p.Val557Ile Multiple submitters
- c.1205+224C>T Single submitter
- c.1206-205A>G Single submitter
- c.1206-244G>A Single submitter
- c.1206-285T>C Single submitter
- c.1206-294T>C Single submitter
- c.1206-313C>T Single submitter
- c.1309+106del Single submitter
- c.1309+173T>C Single submitter
- c.1309+345G>A Single submitter
- c.1310-175A>T Single submitter
- c.1597+233C>G Single submitter
- c.1597+236A>G Single submitter
- c.1598-267A>C Single submitter
- c.165+269C>G Single submitter
- c.166-106G>A Single submitter
- c.166-148G>A Single submitter
- c.166-240C>T Single submitter
- c.1942+314C>G Single submitter
- c.1943-179A>G Single submitter
- c.2053+321C>T Single submitter
- c.2053+67CT[10] Single submitter
- c.2053+67CT[9] Single submitter
- c.2054-243G>A Single submitter
- c.2054-273A>G Single submitter
- c.2290+173A>G Single submitter
- c.2291-225C>T Single submitter
- c.2291-335dup Single submitter
- c.2418+128G>A Single submitter
- c.2418+300G>A Single submitter
- c.2418+38_2418+39del Single submitter
- c.2542-304G>C Single submitter
- c.368+189C>A Single submitter
- c.369-269T>C Single submitter
- c.369-326A>G Single submitter
- c.369-343G>A Single submitter
- c.44-136A>G Single submitter
- c.44-256G>A Single submitter
- c.485-214G>C Single submitter
- c.615-184G>T Single submitter
- c.615-228G>A Single submitter
- c.615-297C>G Single submitter
- c.743-36dup Single submitter
- c.743-9A>G Single submitter
- p.Asp358Val Single submitter
- p.Lys805= Single submitter
Likely benign 40
- c.1597+8A>G Multiple submitters
- p.Arg243Lys Multiple submitters
- p.Asp180= Multiple submitters
- p.Asp324Asn Multiple submitters
- p.Ile344= Multiple submitters
- p.Ser963Leu Multiple submitters
- c.1036+8A>G Single submitter
- c.1597+7C>T Single submitter
- c.166-4G>A Single submitter
- c.166-5C>T Single submitter
- c.1942+8A>G Single submitter
- c.369-4G>A Single submitter
- c.742+9A>G Single submitter
- p.Ala642= Single submitter
- p.Arg961His Single submitter
- p.Arg973Gln Single submitter
- p.Asn541Ser Single submitter
- p.Asn816= Single submitter
- p.Asp324= Single submitter
- p.Cys965Arg Single submitter
- p.Gln338= Single submitter
- p.Glu140= Single submitter
- p.Glu742Asp Single submitter
- p.Gly48= Single submitter
- p.Ile507Val Single submitter
- p.Pro116Arg Single submitter ⚠
- p.Pro460= Single submitter
- p.Pro60= Single submitter
- p.Pro733= Single submitter
- p.Pro893= Single submitter
- p.Ser735= Single submitter
- p.Ser941= Single submitter
- p.Thr475Pro Single submitter ⚠
- p.Thr682= Single submitter
- p.Tyr874= Single submitter
- p.Val16Leu Single submitter
- p.Val852Ile Single submitter
- p.Ala813= No assertion criteria FLT3-related disorder
- p.Ser446Leu No assertion criteria FLT3-related disorder ⚠
- p.Val95= No assertion criteria FLT3-related disorder
Uncertain significance 78
- p.Ala149Asp Single submitter ⚠
- p.Ala291Pro Single submitter ⚠
- p.Ala425Ser Single submitter ⚠
- p.Ala447Gly Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Ala66Val Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg961Cys Single submitter ⚠
- p.Asn306His Single submitter ⚠
- p.Asn434Ser Single submitter ⚠
- p.Asn847Ser Single submitter ⚠
- p.Asp398Tyr Single submitter ⚠
- p.Asp540His Single submitter ⚠
- p.Asp62Gly Single submitter ⚠
- p.Asp779Val Single submitter ⚠
- p.Asp84Gly Single submitter ⚠
- p.Cys828Arg Single submitter ⚠
- p.Cys965Tyr Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln363Glu Single submitter ⚠
- p.Gln667Lys Single submitter ⚠
- p.Gln903Pro Single submitter ⚠
- p.Glu140Gln Single submitter ⚠
- p.Glu209Gly Single submitter ⚠
- p.Glu217Gly Single submitter ⚠
- p.Glu240Ala Single submitter ⚠
- p.Glu672Lys Single submitter ⚠
- p.Glu803Gly Single submitter ⚠
- p.Gly295Asp Single submitter ⚠
- p.Gly295Ser Single submitter ⚠
- p.Gly493Val Single submitter ⚠
- p.Gly739Ala Single submitter ⚠
- p.Gly960Asp Single submitter ⚠
- p.His279Arg Single submitter ⚠
- p.His967Tyr Single submitter ⚠
- p.Ile361Thr Single submitter ⚠
- p.Ile38Asn Single submitter ⚠
- p.Ile674Thr Single submitter ⚠
- p.Ile881Thr Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu257Trp Single submitter ⚠
- p.Leu983Val Single submitter ⚠
- p.Lys175Arg Single submitter ⚠
- p.Lys207Ile Single submitter ⚠
- p.Lys263Glu Single submitter ⚠
- p.Lys334Thr Single submitter ⚠
- p.Lys429Thr Single submitter ⚠
- p.Lys490Arg Single submitter ⚠
- p.Lys513Asn Single submitter ⚠
- p.Lys565Glu Single submitter ⚠
- p.Lys709Thr Single submitter ⚠
- p.Met128Val Single submitter ⚠
- p.Met430Ile Single submitter ⚠
- p.Met645Leu Single submitter ⚠
- p.Phe156Leu Single submitter ⚠
- p.Phe281Leu Single submitter ⚠
- p.Phe537Val Single submitter ⚠
- p.Phe906Leu Single submitter ⚠
- p.Pro413Ser Single submitter ⚠
- p.Pro937Arg Single submitter ⚠
- p.Ser356Asn Single submitter ⚠
- p.Ser461Phe Single submitter ⚠
- p.Ser504Arg Single submitter ⚠
- p.Ser806Leu Single submitter ⚠
- p.Ser941Leu Single submitter ⚠
- p.Ser976Arg Single submitter ⚠
- p.Thr382Ala Single submitter ⚠
- p.Thr90Ala Single submitter ⚠
- p.Trp872Cys Single submitter ⚠
- p.Tyr328Ser Single submitter ⚠
- p.Tyr457Asn Single submitter ⚠
- p.Tyr919Cys Single submitter ⚠
- p.Val125Gly Single submitter ⚠
- p.Val275Ile Single submitter ⚠
- p.Val317Glu Single submitter ⚠
- p.Val512Ile Single submitter ⚠
- p.Val871Ile Single submitter ⚠
- p.Val894Ala Single submitter ⚠