CD86 — 55 ClinVar variants
All ClinVar germline CD86 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 11 Likely benign · 42 Uncertain significance
Full CD86 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD86 p.Ala24Val Uncertain significance Single submitter
- CD86 p.Arg277Cys Uncertain significance Single submitter
- CD86 p.Arg277His Uncertain significance Single submitter
- CD86 p.Arg306Ile Uncertain significance Single submitter
- CD86 p.Asp104Glu Uncertain significance Single submitter
- CD86 p.Gln311Glu Uncertain significance Single submitter
- CD86 p.Glu288Gly Uncertain significance Single submitter
- CD86 p.Glu288Val Uncertain significance Single submitter
- CD86 p.Ile12Val Uncertain significance Single submitter
- CD86 p.Ile153Leu Uncertain significance Single submitter
- CD86 p.Leu236Pro Uncertain significance Single submitter
- CD86 p.Lys274Gln Uncertain significance Single submitter
- CD86 p.Met16Val Uncertain significance Single submitter
- CD86 p.Met261Ile Uncertain significance Single submitter
- CD86 p.Met261Val Uncertain significance Single submitter
- CD86 p.Met83Ile Uncertain significance Single submitter
- CD86 p.Met83Thr Uncertain significance Single submitter
- CD86 p.Met83Val Uncertain significance Single submitter
- CD86 p.Pro117Thr Uncertain significance Single submitter
- CD86 p.Ser137Thr Uncertain significance Single submitter
- CD86 p.Ser212Asn Uncertain significance Single submitter
- CD86 p.Ser307Ala Uncertain significance Single submitter
- CD86 p.Thr211Lys Uncertain significance Single submitter
- CD86 p.Tyr152His Uncertain significance Single submitter
- CD86 p.Val142Leu Uncertain significance Single submitter
- CD86 p.Val151Ala Uncertain significance Single submitter
- CD86 p.Val313Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CD86 p.Glu181Ala Uncertain significance Single submitter
- CD86 p.Glu73Gln Uncertain significance Single submitter
- CD86 p.Glu73Gly Uncertain significance Single submitter
- CD86 p.Gly184Val Uncertain significance Single submitter
- CD86 p.His161Tyr Uncertain significance Single submitter
- CD86 p.Leu107Phe Uncertain significance Single submitter
- CD86 p.Leu38Val Uncertain significance Single submitter
- CD86 p.Pro231Ser Uncertain significance Single submitter
- CD86 p.Pro25Ser Likely benign Single submitter
- CD86 p.Ser170Asn Uncertain significance Single submitter
- CD86 p.Ser170Gly Uncertain significance Single submitter
- CD86 p.Ser204Cys Uncertain significance Single submitter
- CD86 p.Thr211Met Uncertain significance Single submitter
- CD86 p.Trp268Arg Likely benign Single submitter
- CD86 p.Tyr152Cys Uncertain significance Single submitter
- CD86 p.Val132Met Uncertain significance Single submitter
- CD86 p.Val199Ile Uncertain significance Single submitter
All CD86 variants
Benign 2
- p.Ala310Thr Multiple submitters
- p.Asp323Asn Multiple submitters
Likely benign 11
- p.Arg226Gln Single submitter
- p.Arg275Gln Single submitter
- p.Arg312Cys Single submitter
- p.Arg312His Single submitter
- p.Asp198Asn Single submitter
- p.Ile180Thr Single submitter
- p.Ile258Val Single submitter
- p.Pro25Ser Single submitter ⚠
- p.Ser317Leu Single submitter
- p.Ser77Asn Single submitter
- p.Trp268Arg Single submitter ⚠
Uncertain significance 42
- p.Ala24Val Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg277His Single submitter ⚠
- p.Arg306Ile Single submitter ⚠
- p.Asp104Glu Single submitter ⚠
- p.Gln311Glu Single submitter ⚠
- p.Glu181Ala Single submitter ⚠
- p.Glu288Gly Single submitter ⚠
- p.Glu288Val Single submitter ⚠
- p.Glu73Gln Single submitter ⚠
- p.Glu73Gly Single submitter ⚠
- p.Gly184Val Single submitter ⚠
- p.His161Tyr Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Ile153Leu Single submitter ⚠
- p.Leu107Phe Single submitter ⚠
- p.Leu236Pro Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Lys274Gln Single submitter ⚠
- p.Met16Val Single submitter ⚠
- p.Met261Ile Single submitter ⚠
- p.Met261Val Single submitter ⚠
- p.Met83Ile Single submitter ⚠
- p.Met83Thr Single submitter ⚠
- p.Met83Val Single submitter ⚠
- p.Pro117Thr Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Ser137Thr Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser170Gly Single submitter ⚠
- p.Ser204Cys Single submitter ⚠
- p.Ser212Asn Single submitter ⚠
- p.Ser307Ala Single submitter ⚠
- p.Thr211Lys Single submitter ⚠
- p.Thr211Met Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr152His Single submitter ⚠
- p.Val132Met Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val151Ala Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val313Ile Single submitter ⚠