Sugi Variant

Sugi Variant/CNGA3

CNGA3 — 785 ClinVar variants

All ClinVar germline CNGA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 329 flagged for review →

101 Pathogenic · 28 Pathogenic/Likely pathogenic · 87 Likely pathogenic · 59 Conflicting · 16 Benign · 7 Benign/Likely benign · 190 Likely benign · 297 Uncertain significance

Full CNGA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 329

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 16

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 19

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 156

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 156

Predictors split 138

The independent predictors disagree with each other — read with care.

All CNGA3 variants

Pathogenic 101

Pathogenic/Likely pathogenic 28

Likely pathogenic 87

Conflicting classifications of pathogenicity 59

Benign 16

Benign/Likely benign 7

Likely benign 190

Uncertain significance 297