FLRT1 — 205 ClinVar variants

All ClinVar germline FLRT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more.

2 Conflicting · 20 Benign · 1 Benign/Likely benign · 50 Likely benign · 132 Uncertain significance

Full FLRT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

All FLRT1 variants

Conflicting classifications of pathogenicity 2

p.Ile653Thr Single submitter peripheral neuropathy
p.Val22Ile Single submitter peripheral neuropathy

Benign 20

p.Glu631= Multiple submitters peripheral neuropathy
p.Ala96= Multiple submitters peripheral neuropathy
p.Arg238= Multiple submitters peripheral neuropathy
p.Arg298Gln Multiple submitters peripheral neuropathy
p.Asp82= Multiple submitters peripheral neuropathy
p.Ile611= Multiple submitters peripheral neuropathy
p.Leu153= Multiple submitters peripheral neuropathy
p.Leu336= Multiple submitters peripheral neuropathy
p.Lys274= Multiple submitters peripheral neuropathy
p.Phe36= Multiple submitters peripheral neuropathy
p.Pro522= Multiple submitters peripheral neuropathy
p.Ser245= Multiple submitters peripheral neuropathy
p.Tyr516= Multiple submitters peripheral neuropathy
p.Tyr576= Multiple submitters peripheral neuropathy
p.Tyr655= Multiple submitters peripheral neuropathy
p.Ala262= Single submitter peripheral neuropathy
p.Ala390= Single submitter peripheral neuropathy
p.Arg592= Single submitter peripheral neuropathy
p.Thr19= Single submitter peripheral neuropathy
p.Tyr39= Single submitter peripheral neuropathy

Benign/Likely benign 1

p.Pro626= Multiple submitters peripheral neuropathy

Likely benign 50

p.Asp136Gly Multiple submitters peripheral neuropathy
p.Asp315= Multiple submitters peripheral neuropathy
p.Ala240= Single submitter peripheral neuropathy
p.Ala261= Single submitter peripheral neuropathy
p.Ala476= Single submitter peripheral neuropathy
p.Arg32= Single submitter peripheral neuropathy
p.Arg615= Single submitter peripheral neuropathy
p.Arg615Cys Single submitter peripheral neuropathy
p.Arg628His Single submitter
p.Asn544= Single submitter peripheral neuropathy
p.Asn62= Single submitter peripheral neuropathy
p.Asn642= Single submitter peripheral neuropathy
p.Asn95= Single submitter peripheral neuropathy
p.Asp171= Single submitter peripheral neuropathy
p.Asp241= Single submitter peripheral neuropathy
p.Cys332= Single submitter peripheral neuropathy
p.Cys60= Single submitter peripheral neuropathy
p.Gln543= Single submitter peripheral neuropathy
p.Glu374Asp Single submitter peripheral neuropathy
p.Glu631= Single submitter peripheral neuropathy
p.Gly195= Single submitter peripheral neuropathy
p.Gly385= Single submitter peripheral neuropathy
p.Gly386= Single submitter peripheral neuropathy
p.Gly555= Single submitter peripheral neuropathy
p.His442= Single submitter peripheral neuropathy
p.Ile573= Single submitter peripheral neuropathy
p.Leu233= Single submitter peripheral neuropathy
p.Leu275= Single submitter peripheral neuropathy
p.Leu290= Single submitter peripheral neuropathy
p.Leu41= Single submitter peripheral neuropathy
p.Leu494= Single submitter peripheral neuropathy
p.Leu551= Single submitter peripheral neuropathy
p.Pro429= Single submitter peripheral neuropathy
p.Pro640His Single submitter peripheral neuropathy
p.Pro667= Single submitter peripheral neuropathy
p.Pro76= Single submitter peripheral neuropathy
p.Ser254= Single submitter peripheral neuropathy
p.Ser259= Single submitter peripheral neuropathy
p.Ser463= Single submitter peripheral neuropathy
p.Thr12= Single submitter peripheral neuropathy
p.Thr165= Single submitter peripheral neuropathy
p.Thr395Met Single submitter peripheral neuropathy
p.Thr404= Single submitter peripheral neuropathy
p.Thr454= Single submitter peripheral neuropathy
p.Thr481= Single submitter peripheral neuropathy
p.Tyr114= Single submitter peripheral neuropathy
p.Tyr600Cys Single submitter peripheral neuropathy
p.Val343= Single submitter
p.Arg311= No assertion criteria FLRT1-related disorder
p.Leu317= No assertion criteria FLRT1-related disorder

Uncertain significance 132

p.Ala148Gly Multiple submitters peripheral neuropathy
p.Ala461Thr Multiple submitters peripheral neuropathy
p.Arg149Cys Multiple submitters peripheral neuropathy
p.Arg326Lys Multiple submitters peripheral neuropathy
p.Arg364Gln Multiple submitters peripheral neuropathy
p.Arg452His Multiple submitters peripheral neuropathy
p.Arg465Gln Multiple submitters FLRT1-related disorder
p.Arg586Gln Multiple submitters peripheral neuropathy
p.Arg592Gln Multiple submitters peripheral neuropathy
p.Arg592Trp Multiple submitters peripheral neuropathy
p.Asn305Lys Multiple submitters peripheral neuropathy
p.Asp598Asn Multiple submitters peripheral neuropathy
p.Glu374Gln Multiple submitters peripheral neuropathy
p.Gly71Arg Multiple submitters peripheral neuropathy
p.Ile426Thr Multiple submitters peripheral neuropathy
p.Ile669Thr Multiple submitters peripheral neuropathy
p.Ser146Leu Multiple submitters peripheral neuropathy
p.Ser194Leu Multiple submitters peripheral neuropathy
p.Ser259Leu Multiple submitters peripheral neuropathy
p.Ser401Tyr Multiple submitters peripheral neuropathy
p.Ser594Gly Multiple submitters peripheral neuropathy
p.Thr13Arg Multiple submitters peripheral neuropathy
p.Thr13Met Multiple submitters peripheral neuropathy
p.Thr84Ile Multiple submitters peripheral neuropathy
p.Val166Ile Multiple submitters peripheral neuropathy
p.Ala172Thr Single submitter
p.Ala347Val Single submitter
p.Ala348Thr Single submitter peripheral neuropathy
p.Ala388Val Single submitter
p.Ala390Thr Single submitter
p.Ala436Thr Single submitter
p.Ala549Gly Single submitter
p.Ala549Val Single submitter peripheral neuropathy
p.Ala562Thr Single submitter
p.Ala77Thr Single submitter peripheral neuropathy
p.Arg127His Single submitter
p.Arg130Gln Single submitter peripheral neuropathy
p.Arg226Cys Single submitter
p.Arg226His Single submitter peripheral neuropathy
p.Arg238His Single submitter
p.Arg246Cys Single submitter peripheral neuropathy
p.Arg257Cys Single submitter
p.Arg257His Single submitter
p.Arg294Leu Single submitter peripheral neuropathy
p.Arg32Gly Single submitter
p.Arg452Cys Single submitter
p.Arg465Trp Single submitter
p.Arg586Trp Single submitter
p.Arg59His Single submitter peripheral neuropathy
p.Arg628Cys Single submitter
p.Arg659Gln Single submitter peripheral neuropathy
p.Arg659Trp Single submitter
p.Arg662Trp Single submitter
p.Arg70Trp Single submitter
p.Asp175Asn Single submitter peripheral neuropathy
p.Asp241Val Single submitter peripheral neuropathy
p.Asp315Asn Single submitter
p.Asp341Asn Single submitter
p.Asp341His Single submitter
p.Asp423Asn Single submitter
p.Asp531Asn Single submitter hereditary spastic paraplegia
p.Asp599Gly Single submitter
p.Asp608Gly Single submitter
p.Cys38Trp Single submitter
p.Gln486Pro Single submitter
p.Gln579His Single submitter
p.Glu582Lys Single submitter
p.Glu632Gly Single submitter
p.Gly312Ser Single submitter
p.Gly418Glu Single submitter peripheral neuropathy
p.Gly534Asp Single submitter
p.Gly558Ser Single submitter
p.Gly571Val Single submitter peripheral neuropathy
p.Gly593Asp Single submitter
p.Gly604Glu Single submitter
p.Gly616Ser Single submitter
p.Gly63Ser Single submitter
p.Gly665Ser Single submitter peripheral neuropathy
p.Gly97Ala Single submitter peripheral neuropathy
p.His157Gln Single submitter peripheral neuropathy
p.His473Arg Single submitter
p.His578Arg Single submitter peripheral neuropathy
p.Ile111Val Single submitter
p.Ile282Val Single submitter
p.Ile480Thr Single submitter
p.Leu181Arg Single submitter
p.Leu189Met Single submitter
p.Leu355His Single submitter
p.Leu41Phe Single submitter
p.Leu459Ile Single submitter
p.Leu646Phe Single submitter peripheral neuropathy
p.Lys456Asn Single submitter
p.Met29Lys Single submitter peripheral neuropathy
p.Met356Leu Single submitter peripheral neuropathy
p.Met430Val Single submitter
p.Met548Ile Single submitter peripheral neuropathy
p.Phe410Tyr Single submitter peripheral neuropathy
p.Pro429Leu Single submitter
p.Pro475Ala Single submitter
p.Pro626Arg Single submitter
p.Pro626Leu Single submitter
p.Pro6Arg Single submitter
p.Ser223Asn Single submitter
p.Ser223Gly Single submitter peripheral neuropathy
p.Ser373Arg Single submitter
p.Thr11Asn Single submitter
p.Thr19Met Single submitter
p.Thr251Lys Single submitter
p.Thr25Asn Single submitter
p.Thr289Met Single submitter peripheral neuropathy
p.Thr381Arg Single submitter
p.Thr381Met Single submitter
p.Thr404Met Single submitter
p.Thr432Met Single submitter
p.Thr447Met Single submitter
p.Thr454Pro Single submitter
p.Thr458Met Single submitter
p.Thr512Pro Single submitter
p.Thr52Ser Single submitter
p.Thr537Ala Single submitter
p.Thr650Ile Single submitter
p.Tyr600Asn Single submitter
p.Tyr87His Single submitter
p.Tyr87Phe Single submitter
p.Val22_Thr28del Single submitter peripheral neuropathy
p.Val343Leu Single submitter
p.Val349Met Single submitter
p.Val363Phe Single submitter
p.Val477Met Single submitter
p.Val569Ile Single submitter
p.Val577Leu Single submitter peripheral neuropathy
p.Val577Met Single submitter peripheral neuropathy