Is FLRT1 p.Ile426Thr (c.1277T>C) pathogenic?

FLRT1 p.Ile426Thr (c.1277T>C) is classified Uncertain significance in FLRT1 (ClinVar, Multiple submitters, 2 submitters; last evaluated 2025-01-06). Ultra-rare (popmax 0.0166%, mid); Associated with peripheral neuropathy.

What condition is associated with FLRT1 p.Ile426Thr (c.1277T>C)?

FLRT1 p.Ile426Thr (c.1277T>C) is associated with peripheral neuropathy (ClinVar).

How common is FLRT1 p.Ile426Thr (c.1277T>C) in the general population?

FLRT1 p.Ile426Thr (c.1277T>C) is ultra-rare (popmax 0.0166%, mid) (gnomAD).

FLRT1 p.Ile426Thr

c.1277T>C · rs770341979 · VCV1061128

Uncertain significance Multiple submitters

Classification

Uncertain significance

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 2 submitters

gnomAD v4.1

Rare

ultra-rare (popmax 0.0166%, mid)

Conditions

peripheral neuropathy

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
REVEL	0.114	moderately benign-leaning
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 5	GERP 0.85, phastCons 0.99
Regional constraint	o/e 0.78	unconstrained · MANE · 2,021 bp · p 5.7e-12 · regional, not allelic
Overall
CADD	16.85	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0166% Middle Eastern · 1/6,030 alleles

Filtering AF 0.00549% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00509%

Overall 0.00617% 99/1,603,680 alleles · ultra-rare exomes 92/1,451,472 · genomes 7/152,208 · joint denominator

Ancestry group	Frequency	1 in
Middle Easterngrpmax	0.0166%	6,030
Admixed American	0.0101%	9,883
African / African-American	0.00937%	10,673
European (non-Finnish)	0.00673%	14,852
South Asian	0.00332%	30,079
Remaining individualsnot grpmax-eligible	0.00323%	30,939
East Asian	0.00224%	44,662

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: FLRT1
Protein: p.Ile426Thr
Coding: c.1277T>C
MANE Select: NM_013280
dbSNP: rs770341979
Type: single nucleotide variant
Location: chr11:64117544 (GRCh38)
Gene constraint: LOEUF 0.682 · pLI 0.14 (gnomAD)
Structure: AlphaFold pLDDT 73.46

Full FLRT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

peripheral neuropathy — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

FLRT1 p.Ala148Gly Uncertain significance ★★ same condition
FLRT1 p.Ala461Thr Uncertain significance ★★ same condition
FLRT1 p.Arg149Cys Uncertain significance ★★ same condition
FLRT1 p.Arg326Lys Uncertain significance ★★ same condition
FLRT1 p.Arg452His Uncertain significance ★★ same condition
FLRT1 p.Arg586Gln Uncertain significance ★★ same condition
FLRT1 p.Arg592Gln Uncertain significance ★★ same condition
FLRT1 p.Arg592Trp Uncertain significance ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/flrt1-p-ile426thr (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown