Sugi Variant

Sugi Variant/HRAS

HRAS — 652 ClinVar variants

All ClinVar germline HRAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 240 flagged for review →

20 Pathogenic · 7 Pathogenic/Likely pathogenic · 22 Likely pathogenic · 24 Conflicting · 34 Benign · 4 Benign/Likely benign · 243 Likely benign · 298 Uncertain significance

Full HRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 240

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 152

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 152

Predictors split 82

The independent predictors disagree with each other — read with care.

All HRAS variants

Pathogenic 20

Pathogenic/Likely pathogenic 7

Likely pathogenic 22

Conflicting classifications of pathogenicity 24

Benign 34

Benign/Likely benign 4

  • c.*1C>T Multiple submitters
  • p.Ala121= Multiple submitters Noonan syndrome and Noonan-related syndrome
  • p.Ala18= Multiple submitters Cardiovascular phenotype
  • p.Leu52= Multiple submitters Cardiovascular phenotype

Likely benign 243

Uncertain significance 298