HRAS p.Pro167=
c.501G>A · rs764211685 · VCV1198269
Likely benign
Multiple submitters
Classification
Likely benign
ClinVar
Review
Multiple submitters ★★☆☆
ClinVar · 2 submitters
gnomAD v4.1
Rare
ultra-rare (popmax 0.017%, mid)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP 1.9 | GERP 0.98, phastCons 0.67 |
| Overall | ||
| CADD | 21.1 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
0.017%
Middle Eastern · 1/5,890 alleles
Filtering AF
0.0036%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 0.00255%
Overall
0.002%
32/1,600,632 alleles · ultra-rare
exomes 28/1,448,754 · genomes 4/151,878 · joint denominator
| Ancestry group | Frequency | 1 in |
|---|---|---|
| Middle Easterngrpmax | 0.017% | 5,890 |
| South Asian | 0.00771% | 12,967 |
| Admixed American | 0.0067% | 14,932 |
| East Asian | 0.00224% | 44,700 |
| Remaining individualsnot grpmax-eligible | 0.00161% | 62,172 |
| European (non-Finnish) | 0.00153% | 65,481 |
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- HRAS
- Protein
- p.Pro167=
- Coding
- c.501G>A
- MANE Select
- NM_005343 · reported on NM_176795
- dbSNP
- rs764211685
- Type
- single nucleotide variant
- Location
- chr11:533308 (GRCh38)
- Gene constraint
- LOEUF 0.893 · pLI 0.02 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 92.50 · 256 PDB
- Residue 167
- the 'hypervariable region' region
Similar variants
- HRAS p.Lys167Arg Uncertain significance ★ ⚠ same residue
- HRAS p.Pro167Leu Likely benign ★ same residue
- HRAS p.Pro167fs Uncertain significance ★ same residue
- HRAS p.Ala59Thr Likely pathogenic ★★★ same type
- HRAS p.Gly12Ser Pathogenic ★★★ same type
- HRAS p.Gly13Cys Pathogenic ★★★ same type
- HRAS p.Lys117Arg Pathogenic ★★★ same type
- HRAS p.Thr58Ile Pathogenic ★★★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/hras-p-pro167 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown