HRAS p.Pro167fs
c.490_499dup · VCV4086451
Uncertain significance
Single submitter
Classification
Uncertain significance
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
Consequence
frameshift
predicted LoF
gnomAD v4.1
Rare
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Consequence | frameshift | predicted loss-of-function; NMD-escape possible for C-terminal truncations |
|---|---|---|
| Splicing | ||
| SpliceAI | — | not assessed · substitutions only |
| Constraint at this position | ||
| Conservation | phyloP 0.98 | GERP -0.32, phastCons 0.42 |
Predicted loss-of-function is descriptive, not an applied PVS1 code.
Variant & gene context
- Gene
- HRAS
- Protein
- p.Pro167fs
- Coding
- c.490_499dup
- MANE Select
- NM_005343 · reported on NM_176795
- Type
- Duplication
- Location
- chr11:533309 (GRCh38)
- Gene constraint
- LOEUF 0.893 · pLI 0.02 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 92.50 · 256 PDB
- Residue 167
- the 'hypervariable region' region
Similar variants
- HRAS p.Pro167= Likely benign ★★ same residue
- HRAS p.Lys167Arg Uncertain significance ★ ⚠ same residue
- HRAS p.Pro167Leu Likely benign ★ same residue
- HRAS p.Glu63_Asp69dup Likely pathogenic ★★ same type
- HRAS p.Met72_Arg73insHisSerAlaMetArgAspGlnTyrMet Likely pathogenic ★★ same type
- HRAS p.Met72_Arg73insProMetArgAspGlnTyrMet Pathogenic/Likely pathogenic ★★ same type
- HRAS p.Glu37fs Uncertain significance ★★ same type
- HRAS p.Arg73_Thr74insAsnSerAlaMetArgAspGlnTyrMetArg Likely pathogenic ★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/hras-p-pro167fs (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown