Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 8/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116308 | 0.85 | KDM1A (0.48) | ERBB2MAP2K1RAD52KMT2AKDM1A | |
| SCHEMBL3759286 | 0.83 | KDM1A (0.53) | ERBB2KDRHTTRAD52KMT2A | |
| SCHEMBL3764035 | 0.77 | KMT2A (0.58) | LMNAPOLBRAD52KMT2AKDM1A | |
| SCHEMBL10000194 | 0.76 | ERBB2 (0.94) | ERBB2KDRTEKHTTRAD52 | |
| SCHEMBL13056988 | 0.76 | ABCG2 (0.55) | LMNAPOLBKMT2AGFERMAPT | |
| SCHEMBL21863308 | 0.75 | NPY5R (0.54) | HTTLMNARAB9AMAPT | |
| SCHEMBL18879049 | 0.74 | GPR3 (0.44) | LMNAKDM1ARAB9AKDM4EMAPT | |
| SCHEMBL1387165 | 0.74 | ERBB2 (1.00) | ERBB2KDRTEKHTTRAF1 | |
| SCHEMBL4739613 | 0.73 | FADS1 (0.63) | ERBB2KMT2AACP1RAB9AKDM4E | |
| SCHEMBL1116019 | 0.73 | EGFR (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2011016952-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | ERBB2 305/4885KDR 2824/4885TEK 1710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.