SCHEMBL10000250

SCHEMBL10000250

Cc1ccc(-c2ccc(-c3ccc(C)cc3)nc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.54
CCR5 P51681 1/20 0.54
CCR8 P51685 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
KDM1A O60341 1/20 0.53
CYP3A4 P08684 1/20 0.47
CYP2A6 P11509 1/20 0.47
METAP2 P50579 1/20 0.47
METAP1 P53582 1/20 0.47
PDGFRB P09619 2/20 0.46
PDGFRA P16234 2/20 0.46
AURKA O14965 1/20 0.46
ABL1 P00519 1/20 0.46
NTRK1 P04629 1/20 0.46
LCK P06239 1/20 0.46
CSF1R P07333 1/20 0.46
RET P07949 1/20 0.46
MET P08581 1/20 0.46
PIM1 P11309 1/20 0.46
FLT3 P36888 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4404647 0.93 CCR1 (0.64) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL12339169 0.92 MEN1 (0.50) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL2187794 0.92 MEN1 (0.50) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL10000248 0.91 CCR1 (0.68) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL12339157 0.90 NPC1 (0.50) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL12339161 0.90 NPC1 (0.50) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL28873007 0.90 AURKA (0.59) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL15783723 0.90 KDM1A (0.46) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL17051548 0.89 KDM1A (0.49) CCR1CCR5CCR8HDAC6KDM1A
SCHEMBL17051535 0.89 KDM1A (0.49) CCR1CCR5CCR8HDAC6KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10038143-B2 Polymer compound, material for electronic elements, material for organic electroluminescent elements, and organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2018-07-31 US disclosed
US-20160372684-A1 DONOR-ACCEPTOR NANOHOOP COMPOUNDS AND METHODS OF MAKING AND USING THE SAME UNIVERSITY OF OREGON 2016-12-22 US disclosed
US-20150249215-A1 POLYMER COMPOUND, MATERIAL FOR ELECTRONIC ELEMENTS, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2015-09-03 US disclosed
US-8981354-B2 Organic light-emitting polymer and device CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2015-03-17 US disclosed
US-8981354-B2 Organic light-emitting polymer and device CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2015-03-17 US disclosed
US-20130299787-A1 ORGANIC LIGHT-EMITTING DEVICE AND METHOD SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-11-14 US disclosed
US-20130299787-A1 ORGANIC LIGHT-EMITTING DEVICE AND METHOD SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-11-14 US disclosed
US-20130146852-A1 ORGANIC LIGHT-EMITTING POLYMER AND DEVICE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-06-13 US disclosed
US-20130146852-A1 ORGANIC LIGHT-EMITTING POLYMER AND DEVICE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-06-13 US disclosed
US-20130137869-A1 LUMINOPHORES UNIVERSITY OF YORK (UK) 2013-05-30 US disclosed
US-20130075714-A1 POLYMER, POLYMER COMPOSITION AND ORGANIC LIGHT-EMITTING DEVICE SUMTOMO CHEMICAL COMPANY LIMITED (JP) 2013-03-28 US disclosed
US-8158020-B2 Liquid crystal element, optical path deflecting element, and image displaying apparatus RICOH COMPANY, LTD. (JP) 2012-04-17 US disclosed
US-8158020-B2 Liquid crystal element, optical path deflecting element, and image displaying apparatus RICOH COMPANY, LTD. (JP) 2012-04-17 US disclosed
US-7988882-B2 Polymerizable liquid crystal compound, phase difference film and liquid crystal display using the same FUJIFILM CORPORATION (JP) 2011-08-02 US disclosed
WO-2010112799-A1 LUMINOPHORES COMPRISING PLATINUM-LIGAND COMPLEXES UNIVERSITY OF YORK (GB) 2010-10-07 WO disclosed
US-20100047478-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, PHASE DIFFERENCE FILM AND LIQUID CRYSTAL DISPLAY USING THE SAME FUJIFILM CORPORATION (JP) 2010-02-25 US disclosed
US-20080204608-A1 Liquid Crystal Element, Optical Path Deflecting Element, and Image Displaying Apparatus RICOH COMPANY, LTD. (JP) 2008-08-28 US disclosed
US-20080204608-A1 Liquid Crystal Element, Optical Path Deflecting Element, and Image Displaying Apparatus RICOH COMPANY, LTD. (JP) 2008-08-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100047478-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, PHASE DIFFERENCE FILM AND LIQUID CRYSTAL DISPLAY USING THE SAME SP1, PAXBP1, CCNT1 CCR1 175/4885CCR5 2260/4885CCR8 1538/4885
US-20160372684-A1 DONOR-ACCEPTOR NANOHOOP COMPOUNDS AND METHODS OF MAKING AND USING THE SAME NCL, NQO1, NDUFV2 CCR1 3715/4885CCR5 1928/4885CCR8 2390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.