SCHEMBL10000445

SCHEMBL10000445

Cc1cc(C(=O)c2ccc(C#Cc3ccccc3)cc2)cc(N2C(=O)c3ccc(C#Cc4ccccc4)cc3C2=O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA9 Q16790 3/20 0.46
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
HSD17B10 Q99714 1/20 0.43
APEX1 P27695 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALDH1A1 P00352 2/20 0.41
GRM5 P41594 5/20 0.40
MEN1 O00255 1/20 0.40
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
CA2 P00918 1/20 0.40
SCN2A Q99250 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GAA P10253 1/20 0.40
PKM P14618 1/20 0.40
HTT P42858 1/20 0.40
POLB P06746 1/20 0.39
ESR1 P03372 1/20 0.39
VCP P55072 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14114058 0.87 ALDH1A1 (0.41) CA9CA12CA1HSD17B10APEX1
SCHEMBL13132630 0.82 CA1 (0.50) CA9CA12CA1NPSR1ALDH1A1
SCHEMBL13132794 0.82 CA1 (0.50) CA9CA12CA1NPSR1ALDH1A1
SCHEMBL10000440 0.81 POLB (0.44) HSD17B10APEX1ALDH1A1GRM5MEN1
SCHEMBL20716046 0.80 ALDH1A1 (0.55) CA9CA12CA1HSD17B10ALDH1A1
SCHEMBL10000527 0.80 MEN1 (0.46) CA9CA12CA1HSD17B10NPSR1
SCHEMBL9967357 0.80 CA9 (0.51) CA9CA12CA1HSD17B10NPSR1
SCHEMBL13900300 0.79 CA9 (0.66) CA9CA12CA1APEX1NPSR1
SCHEMBL10000450 0.79 MAPK1 (0.53) CA9CA12CA1ALDH1A1GRM5
SCHEMBL29637688 0.79 CA9 (0.66) CA9CA12CA1APEX1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8289833-B2 Method for high density data storage and imaging INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-10-16 US disclosed
US-20120033539-A1 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-02-09 US disclosed