Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10258881 | 0.80 | IGF1R (0.39) | TGFBR1TGFBR2SMN1; SMN2EGFRMAP4K4 | |
| SCHEMBL12395227 | 0.77 | NUDT1 (0.47) | EGFRMAP4K4NUDT1PTPN1PIK3CA | |
| SCHEMBL10292423 | 0.77 | PTPN1 (0.38) | TGFBR1TGFBR2SMN1; SMN2EGFRTDP1 | |
| SCHEMBL12395226 | 0.77 | TGFBR1 (0.34) | TGFBR1TGFBR2EGFRMAP4K4PDE5A | |
| SCHEMBL23241449 | 0.77 | PTPN1 (0.42) | TGFBR1TGFBR2EGFRMAP4K4PDE5A | |
| SCHEMBL10001045 | 0.77 | EGFR (0.33) | TGFBR1TGFBR2EGFRMAP4K4PDE5A | |
| SCHEMBL22151070 | 0.73 | CYP11B2 (0.47) | NUDT1CYP11B2 | |
| SCHEMBL14809960 | 0.71 | PDE4B (0.38) | EGFRPDE5APDE4BHTTALDH1A1 | |
| SCHEMBL14745931 | 0.68 | TDP2 (0.37) | HTTKDM4EALDH1A1 | |
| SCHEMBL12066293 | 0.67 | TGFBR1 (0.42) | TGFBR1HTTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148523-B2 | Intermediates useful in preparing certain pyrrolotriazine compounds and a process for making the intermediates | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148523-B2 | Intermediates useful in preparing certain pyrrolotriazine compounds and a process for making the intermediates | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| EP-2111405-B1 | INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES | BRISTOL MYERS SQUIBB CO (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2008086264-A1 | INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-17 | — | — | WO | disclosed |