Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28599779 | 0.80 | POLB (0.71) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C19 | |
| SCHEMBL13744476 | 0.76 | TSHR (0.72) | SMN1; SMN2POLBCYP1A2CYP2C19ALOX15 | |
| SCHEMBL28535613 | 0.75 | GAA (0.68) | SMN1; SMN2LMNAGAAALOX15ALDH1A1 | |
| SCHEMBL2774243 | 0.75 | TSHR (0.76) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C19 | |
| SCHEMBL28528468 | 0.74 | GAA (0.62) | SMN1; SMN2LMNAPOLBGAAALOX15 | |
| SCHEMBL28085545 | 0.73 | MAOB (0.58) | SMN1; SMN2CYP1A2CYP2C19GAAALOX15 | |
| SCHEMBL10372154 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C19 | |
| SCHEMBL28527764 | 0.71 | GAA (0.62) | SMN1; SMN2LMNAGAAALOX15ALDH1A1 | |
| SCHEMBL20659868 | 0.71 | TSHR (0.69) | LMNAPOLBALOX15ALDH1A1HTT | |
| SCHEMBL15832744 | 0.70 | KMT2A (0.56) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142682-A1 | ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS | UNIVERSITY OF GUELPH (CA) | 2012-06-07 | — | — | US | disclosed |
| US-20120142682-A1 | ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS | UNIVERSITY OF GUELPH (CA) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142682-A1 | ANTIVIRULENCE COMPOUNDS INHIBITING BACTERIAL MONO-ADP-RIBOSYLTRANSFERASE TOXINS | TIPARP, CD38, PARP14 | SMN1; SMN2 4357/4885LMNA 2960/4885POLB 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.