Sugi Predict

Sugi Predict / Compounds / SCHEMBL1000256

SCHEMBL1000256

SCHEMBL1000256

CC(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.49
▸ USP2 O75604 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ CYP2C19 P33261 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.49
▸ CES2 O00748 1/20 0.48
▸ BACE1 P56817 2/20 0.45
▸ CYP4F2 P78329 1/20 0.44
▸ CYP4A11 Q02928 1/20 0.44
▸ MAPT P10636 2/20 0.43
▸ LMNA P02545 3/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ CYP1A1 P04798 1/20 0.42
▸ CYP1B1 Q16678 1/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ TTR P02766 1/20 0.42
▸ TP53 P04637 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17356485 0.89 CYP4F2 (0.56) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL24436817 0.89 CYP3A4 (0.49) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL16961636 0.89 LMNA (0.49) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL4762590 0.89 RXRA (0.48) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL16955997 0.87 CES2 (0.46) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL16961633 0.87 KDM4E (0.43) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL1650557 0.87 KDM4E (0.43) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL7647561 0.85 CES2 (0.50) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL16957692 0.84 CYP4F2 (0.64) KDM4EUSP2ALDH1A1HPGDCYP2C19
SCHEMBL16957689 0.84 LMNA (0.45) KDM4EUSP2ALDH1A1HPGDCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 — — US claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 — — US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 — — US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 — — US claimed
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) 2012-04-12 — — US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 — — WO claimed
US-20040019243-A1 1,3-Bis(trifluoromethyl)benzene derivatives SYNPROTEC LIMITED (GB) 2004-01-29 — — US claimed
EP-0088066-A1 3,5-Bis (trifluoromethyl) phenoxy carboxylic acids and derivatives thereof MONSANTO COMPANY (US) 1983-09-07 — — EP claimed
US-12551555-B2 Compositions and methods for potentiating immune activity KUMQUAT BIOSCIENCES INC. (US) 2026-02-17 — — US disclosed
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP disclosed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO disclosed
US-20230044323-A1 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE ACTIVITY KUMQUAT BIOSCIENCES INC. 2023-02-09 — — US disclosed
EP-4073242-A1 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE ACTIVITY Kumquat Biosciences Inc. (US) 2022-10-19 — — EP disclosed
US-6054445-A KAPPA OPIOID AGONIST ACTIVITY; ANALGESICS AND ANTI-PRURITIC AGENTS ADOLOR CORPORATION (US) 2000-04-25 — — US disclosed
WO-2000014065-A1 KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF ADOLOR CORPORATION (US) 2000-03-16 — — WO disclosed
US-5234944-A Analgesic for mammals ROUSSEL UCLAF (FR) 1993-08-10 — — US disclosed
US-5043347-A Indanes and analgesic compositions and methods thereof ROUSSEL UCLAF (FR) 1991-08-27 — — US disclosed
EP-0088066-A1 3,5-Bis (trifluoromethyl) phenoxy carboxylic acids and derivatives thereof MONSANTO COMPANY (US) 1983-09-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS KDM4E 2134/4885USP2 898/4885ALDH1A1 3087/4885
US-12551555-B2 Compositions and methods for potentiating immune activity PTPRCAP, PTPN2, PTPRC KDM4E 2917/4885USP2 724/4885ALDH1A1 4675/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS KDM4E 2134/4885USP2 898/4885ALDH1A1 3087/4885
US-20230044323-A1 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE ACTIVITY NFATC1, MYD88, ICOS KDM4E 3453/4885USP2 2147/4885ALDH1A1 4200/4885
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS KDM4E 2134/4885USP2 898/4885ALDH1A1 3087/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.