SCHEMBL1000449 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	FAAH	O00519	5/20	0.51

▸	KCNH2	Q12809	4/20	0.51

▸	NPC1	O15118	1/20	0.40

▸	RAB9A	P51151	1/20	0.40

▸	TP53	P04637	2/20	0.37

▸	MAPK13	O15264	2/20	0.36

▸	GCGR	P47871	2/20	0.36

▸	MAPK12	P53778	2/20	0.36

▸	MAPK11	Q15759	2/20	0.36

▸	MAPK14	Q16539	2/20	0.36

▸	KDM4E	B2RXH2	4/20	0.36

▸	GAA	P10253	1/20	0.36

▸	MAPT	P10636	3/20	0.35

▸	MET	P08581	2/20	0.35

▸	APP	P05067	1/20	0.34

▸	HPGD	P15428	2/20	0.34

▸	NPSR1	Q6W5P4	2/20	0.34

▸	MEN1	O00255	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

▸	LMNA	P02545	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1002569	0.89	FAAH (0.42)	FAAHKCNH2KDM4EGAAMAPT
SCHEMBL1002561	0.89	FAAH (0.62)	FAAHKCNH2NPC1RAB9ATP53
SCHEMBL1002327	0.89	FAAH (0.65)	FAAHKCNH2NPC1RAB9ATP53
SCHEMBL1002513	0.80	FAAH (0.54)	FAAHKCNH2TP53KDM4EGAA
SCHEMBL1002415	0.79	FAAH (0.79)	FAAHKCNH2TP53KDM4EMAPT
SCHEMBL1003037	0.79	FAAH (0.54)	FAAHKCNH2KDM4EMAPTAPP
SCHEMBL1002302	0.78	FAAH (0.51)	FAAHKCNH2KDM4EMAPT
SCHEMBL1001827	0.77	FAAH (0.62)	FAAHKCNH2NPC1RAB9ATP53
SCHEMBL1002961	0.77	FAAH (0.65)	FAAHKCNH2NPC1RAB9ATP53
SCHEMBL1847109	0.77	FAAH (0.65)	FAAHKCNH2NPC1RAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9045467-B2	Oxazole derivatives useful as inhibitors of FAAH	MERCK SHARP & DOHME CORP. (US)	2015-06-02	—	—	US	claimed
US-20140171437-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	MERCK SHARP & DOHME CORP. (US)	2014-06-19	—	—	US	claimed
EP-2321288-B1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	MERCK SHARP & DOHME (US)	2014-03-19	—	—	EP	claimed
US-8673941-B2	Oxazole derivatives useful as inhibitors of FAAH	MERCK SHARP & DOHME CORP. (US)	2014-03-18	—	—	US	claimed
JP-2011529965-A	—	—	2011-12-15	—	—	JP	claimed
US-20110144119-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	MERCK SHARP & DOHME LLC	2011-06-16	—	—	US	claimed
EP-2321288-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	Merck & Co., Inc. (US)	2011-05-18	—	—	EP	claimed
US-20110021531-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	MERCK SHARP & DOHME CORP.	2011-01-27	—	—	US	claimed
WO-2010017079-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	MERCK & CO., INC. (US)	2010-02-11	—	—	WO	claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20110144119-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	FAAH, FAAH2, ALOX5	FAAH 1/4885KCNH2 2570/4885NPC1 1094/4885
US-20140171437-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	FAAH, FAAH2, ALOX5	FAAH 1/4885KCNH2 2570/4885NPC1 1094/4885
US-20110021531-A1	OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH	FAAH, FAAH2, ALOX5	FAAH 1/4885KCNH2 2037/4885NPC1 1114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.