Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15386350 | 0.81 | HTT (0.55) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL11653015 | 0.81 | NPC1 (0.60) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL3404282 | 0.80 | SMN1; SMN2 (0.54) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL154696 | 0.80 | ALDH1A1 (0.65) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL12442881 | 0.79 | TSPO (0.43) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL20060898 | 0.79 | JAK2 (0.51) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL1003506 | 0.79 | CPS1 (0.58) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL6931977 | 0.79 | NPC1 (0.50) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL4216899 | 0.79 | KDM4E (0.56) | NPC1RAB9AHPGDALDH1A1CYP3A4 | |
| SCHEMBL8235234 | 0.77 | NPC1 (0.47) | NPC1RAB9AHPGDALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168833-B2 | Schwartz reagents: methods of in situ generation and use | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2012-05-01 | — | — | US | disclosed |
| US-20100145060-A1 | Schwartz Reagents: Methods of In Situ Generation and Use | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145060-A1 | Schwartz Reagents: Methods of In Situ Generation and Use | CBR3, CBR1, ZFR | NPC1 1362/4885RAB9A 4094/4885HPGD 3320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.