Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.51 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10018159 | 0.94 | ALDH1A1 (0.51) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL10018158 | 0.77 | KMT2A (0.46) | ALDH1A1KDM4ELMNARAB9AMAPT | |
| SCHEMBL10018160 | 0.73 | KDM4E (0.42) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL563046 | 0.72 | ALDH1A1 (0.46) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL562165 | 0.69 | ALDH1A1 (0.49) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL18152788 | 0.68 | ALDH1A1 (0.61) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL229828 | 0.68 | ALDH1A1 (1.00) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL562684 | 0.67 | ALDH1A1 (0.50) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL10018161 | 0.67 | TLR7 (0.38) | ALDH1A1SMN1; SMN2KDM4ELMNARAB9A | |
| SCHEMBL9006294 | 0.66 | ALDH1A1 (0.80) | ALDH1A1PDE6DALDH2ALDH3A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | disclosed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | THOC2, TUBGCP2, TBC1D5 | ALDH1A1 1329/4885PDE6D 1821/4885ALDH2 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.