Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562165 | 0.99 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CNR2TNFCXCL8 | |
| SCHEMBL563046 | 0.93 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL10018159 | 0.74 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2TNFCXCL8SOS1 | |
| SCHEMBL563386 | 0.72 | KMT2A (0.43) | ALDH1A1LMNARAB9APDE4APDE4B | |
| SCHEMBL8801413 | 0.68 | MAPT (0.37) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| SCHEMBL10018151 | 0.67 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2TNFLMNARAB9A | |
| SCHEMBL11097622 | 0.65 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL28261637 | 0.63 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2CNR2TNFCXCL8 | |
| SCHEMBL562088 | 0.63 | ADORA3 (0.36) | ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL11090546 | 0.63 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2CNR2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | claimed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | claimed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | claimed |
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | disclosed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | disclosed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | THOC2, TUBGCP2, TBC1D5 | ALDH1A1 1329/4885SMN1; SMN2 2009/4885CNR2 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.