SCHEMBL10018474

SCHEMBL10018474

CCC(COC)N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(N1C(=O)c2ccc4c5c(ccc(c25)C1=O)C(=O)N(C(CC)COC)C4=O)C3=O

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 1/20 0.36
PIN4 Q9Y237 1/20 0.36
TDP1 Q9NUW8 1/20 0.34
TERT O14746 3/20 0.33
CYP1B1 Q16678 1/20 0.33
ALDH1A1 P00352 2/20 0.32
CRHR1 P34998 1/20 0.31
HPGD P15428 1/20 0.30
CASP1 P29466 1/20 0.30
MPI P34949 1/20 0.30
CACNA1B Q00975 1/20 0.30
APBA1 Q02410 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10018480 0.89 PRMT1 (0.40) PIN1PIN4TERTALDH1A1HPGD
SCHEMBL13259607 0.88 PIN1 (0.34) PIN1PIN4TDP1TERTCYP1B1
SCHEMBL18351287 0.88 PIN1 (0.37) PIN1PIN4TDP1TERTALDH1A1
SCHEMBL9915820 0.87 TERT (0.38) PIN1PIN4TDP1TERTCYP1B1
SCHEMBL12382277 0.87 TERT (0.38) PIN1PIN4TDP1TERTCYP1B1
SCHEMBL13259606 0.87 MEN1 (0.35) PIN1PIN4TDP1TERTCYP1B1
SCHEMBL10018472 0.84 TDP1 (0.42) PIN1PIN4TDP1TERTALDH1A1
SCHEMBL10018470 0.82 TDP1 (0.37) TDP1ALDH1A1HPGDSMN1; SMN2NPC1
SCHEMBL12382279 0.81 TERT (0.41) PIN1PIN4TDP1TERTCYP1B1
SCHEMBL10018471 0.81 TDP1 (0.39) PIN1PIN4TDP1TERTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1990682-B1 Electrophotographic photoreceptor, and image forming apparatus and process cartridge using the same RICOH CO LTD (JP) 2015-01-21 EP disclosed
US-8114559-B2 A conductive substrate, a photosensitive layer of a charge generation material of titanyl phthalocyanine, a pyrene diimide electron transport material, substituted triphenylamine hole transport material RICOH COMPANY, LTD. (JP) 2012-02-14 US disclosed
US-8114559-B2 A conductive substrate, a photosensitive layer of a charge generation material of titanyl phthalocyanine, a pyrene diimide electron transport material, substituted triphenylamine hole transport material RICOH COMPANY, LTD. (JP) 2012-02-14 US disclosed
US-7763727-B2 Compound and organic electronic device using the same MITSUI CHEMICALS, INC. (JP) 2010-07-27 US disclosed
US-7763727-B2 Compound and organic electronic device using the same MITSUI CHEMICALS, INC. (JP) 2010-07-27 US disclosed
US-20080280221-A1 Electrophotographic photoreceptor, and image forming apparatus and process cartridge using the same RICOH COMPANY, LTD 2008-11-13 US disclosed
US-20080280221-A1 Electrophotographic photoreceptor, and image forming apparatus and process cartridge using the same RICOH COMPANY, LTD 2008-11-13 US disclosed
EP-1990682-A1 Electrophotographic photoreceptor, and image forming apparatus and process cartridge using the same Ricoh Company, Ltd. (JP) 2008-11-12 EP disclosed
US-20070219375-A1 Novel Compound and Organic Electronic Device Using the Same MITSUI CHEMICALS, INC. (JP) 2007-09-20 US disclosed
US-20070219375-A1 Novel Compound and Organic Electronic Device Using the Same MITSUI CHEMICALS, INC. (JP) 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219375-A1 Novel Compound and Organic Electronic Device Using the Same OR10J3, RPS10, NOX4 PIN1 2534/4885PIN4 1101/4885TDP1 3638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.