Known targets — ChEMBL curated mechanism
TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
The experimentally established mechanism targets of Vinorelbine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 7/20 | 1.00 |
| ▸ | TUBB known ✓ | P07437 | 7/20 | 1.00 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 7/20 | 1.00 |
| ▸ | TUBA1B known ✓ | P68363 | 7/20 | 1.00 |
| ▸ | TUBA4A known ✓ | P68366 | 7/20 | 1.00 |
| ▸ | TUBB4B known ✓ | P68371 | 7/20 | 1.00 |
| ▸ | TUBB3 known ✓ | Q13509 | 7/20 | 1.00 |
| ▸ | TUBB2A known ✓ | Q13885 | 7/20 | 1.00 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 7/20 | 1.00 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 7/20 | 1.00 |
| ▸ | TUBA1A known ✓ | Q71U36 | 7/20 | 1.00 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 7/20 | 1.00 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 7/20 | 1.00 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 7/20 | 1.00 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | TACR2 | P21452 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vinorelbine SCHEMBL12277732 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL16786345 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL13575786 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL13524297 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL4765 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL23077835 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL1653160 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL18220724 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL21610430 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinorelbine SCHEMBL15113116 | 1.00 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173842-B2 | Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt | PIERRE FABRE MEDICAMENT (FR) | 2015-11-03 | — | — | US | disclosed |
| US-8101748-B2 | Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors | PIERRE FABRE MEDICAMENT (FR) | 2012-01-24 | — | — | US | disclosed |
| US-20100196468-A1 | STABLE PHARMACEUTICAL COMPOSITION COMPRISING A HYDROSOLUBLE VINFLUNINE SALT | PIERRE FABRE MEDICAMENT (FR) | 2010-08-05 | — | — | US | disclosed |
| US-20100093997-A1 | FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION AND THEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS | PIERRE FABRE MEDICAMENT (FR) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093997-A1 | FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION AND THEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS | PRMT1, ROS1, CARM1 | TUBB4A 466/4885TUBB 223/4885TUBA3C 253/4885 |
| US-20100196468-A1 | STABLE PHARMACEUTICAL COMPOSITION COMPRISING A HYDROSOLUBLE VINFLUNINE SALT | AVPR2, AVPR1A, PKD1 | TUBB4A 3321/4885TUBB 2723/4885TUBA3C 1934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.